Hassan Salem

Made At Wiko: "Metamorphosis: A Natural and Human History" @basicbooksgroup.bsky.social by Fellow 2022/23 Oren Harman

CC-NLRs exhibit diverse conformations in the resting state. Figure depicts different NLR resting and activated states. While ZAR1 exists as a monomer bound to its guardees in its resting state, several forms have been observed for the NRC2 helper, including dimers, tetramers, and filaments. While filament-like structures were observed via confocal microscopy for NRC2 upon overexpression in planta, these structures were not detected for its paralog NRC4, suggesting a potentially different resting state configuration for NRC4. Our work suggests that the Pik CC-NLR pair forms a hetero-complex bound to the plasma membrane in its resting state. How effector binding to the integrated domain (ID) of the Pik-1 sensor leads to the activation of the complex remains to be determined.

Excited to share our latest work on plant immune receptor biochemistry! @kamounlab.bsky.social @hsuanpai.bsky.social @mpcontreras.bsky.social Jose Salguero Linares @danielluedke.bsky.social @adnroide.bsky.social @jiorgoskourelis.bsky.social

www.biorxiv.org/content/10.6...

📣 Applications are NOW OPEN for our International Undergraduate Summer School 2026

🗓️ 29 June - 22 August 2026
📍 John Innes Centre, NR4 7UH

⏰ Deadline: 16 January 2026

Find out more and apply: www.jic.ac.uk/training-car...

Thanks, Mónica 😊 Hope to catch up soon!

Congratulations to the new cohort of 28 EMBO Young Investigators! They are joining an international network of more than 800 life scientists – Welcome!

Read the press release here:
https://www.embo.org/press-releases/twenty-eight-group-leaders-become-embo-young-investigators/

Molecular basis for cellular compartmentalization by an ancient membrane fission mechanism The emergence of cell compartmentalization depends on membrane fission to create the endomembrane compartments. In eukaryotes, membrane fission is commonly executed by ESCRT-III, a protein complex con...

New preprint from the lab!!🎉
We show that Asgard archaea ESCRT-III proteins can trigger membrane fission and reveal its molecular mechanism, offering clues to how these cells may have built internal compartments. But do these organisms even have these compartments?
www.biorxiv.org/content/10.1...

Thanks, Caroline 😊

New preprint from our group led by @metalichen.bsky.social on the discovery of a Starship giant transposable element in the genome of a lichen-forming fungus.

PhD opportunity in our lab - deadline passes on Dec 2nd - don’t miss out!

🧬🛡️How are new immune mechanisms created?

We show how Lamassu antiphage system, originated from a DNA-repair complex and evolved into a compact and modular immune machine, wt Dinshaw Patel lab in @pnas.org.
👏 @matthieu-haudiquet.bsky.social, Arpita Chakravarti & all authors!

doi.org/10.1073/pnas...

How do new centromeres evolve while staying compatible with the division machinery?

Discover it in our new Nature paper! We show centromeres transition gradually via a mix of drift, selection, and sex, reaching new states that still work with the kinetochore.

👉 doi.org/10.1038/s41586-025-09779-1

Thanks so much, Dario!!

Thanks, Glen!!

Thanks so much, Mark 😊

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Thanks a lot, Nichole 😊

Thanks so much, Philipp 😊!

Thanks so much, John! See you soon in Heidelberg 😊

Thanks ya Mohammed! It’s been forever 😊 Hopefully see you soon

Thanks, Thorsten! It was great sharingTübingen with you and your group 😊

Thanks, Emily 😊 And hopefully see you soon!

Thanks, Sam!!

Thanks, Miguel - and congratulations on the Wellcome news 🎉 Looking forward to meeting you in Norwich!

Thanks, Ashleigh! I’d love that, also hosting you in Norwich 😊

Thanks a lot, Anne!

Thanks for all the support, Christian 😊 Hopefully see you soon in Norwich!

Thanks so much, Tatsuya 😊 Looking forward to catching up in Norwich!

Thanks so much, Ákos!!

Thanks, Ashish! It’d be great to catch up after the move

Thanks so much, Yuko 😊 We’ll hopefully see you soon!