Alexandria Miller

And we’re grateful to you for all that you’ve done to make this happen. Many congrats Nick!

NIH award notice

Happy to share we got the NoA for the NIH S10 proposal I submitted for a Glacios #cryoEM 🔬 for #IowaResearch #structuralbiology

Nobel laureate: I owe America my success. Today, its scientific future is in danger | CNN Dr. Ardem Patapoutian says he watches “with deep sadness as the United States’ remarkable scientific enterprise, which took generations of hard work and national investment to build, faces a concerted...

Scientists are “not opposed to examining how taxpayer funds are used; on the contrary, we welcome efforts to improve efficiency […]. But what’s happening now has nothing to do with efficiency. These actions […] are indiscriminate and risk doing real, long-lasting harm.”

www.cnn.com/2025/04/09/h...

Opinion | We Were Badly Misled About the Event That Changed Our Lives Five years after the start of Covid, we still don’t know the truth.

Irrespective of your opinion on the matter, I think this is an important read to understand why some of the mistrust in science exists in our society today.

NIH Grants Fueled $95 Billion In FY 2024 Economic Activity, Finds New Report National Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Research.

www.forbes.com/sites/michae...

A person dies of measles in West Texas outbreak At least 124 cases have been reported in Texas, with at least 18 hospitalizations. Most are children.

First measles death in a decade. www.nbcnews.com/health/healt...

Trump Administration Stalls Scientific Research Despite Court Ruling (Gift Article) Using an arcane law, officials have effectively delayed funding from the National Institutes of Health, leaving medical studies in jeopardy.

New York Times article now up on Federal Register stuff.

www.nytimes.com/2025/02/21/s...

1/n

The Channels, Receptors & Transporters Subgroup of the @biophysicalsoc.bsky.social is excited to announce the final program for our 2025 Symposium. Please join us on Feb 15 to hear from @willowcoyote.bsky.social @drcontrexin.bsky.social @corrylab.bsky.social and others 👇Thanks to our sponsors!

Fresh out of the press! ✨Check out our new paper on the violent entry of the HIV capsid into the nuclear pore — and how it cracks the gate! 🤯 💥 Incredible work from @becklab.bsky.social and @hummerlab.bsky.social 🤩 More here: www.biophys.mpg.de/2842024/hivcapsid-cracks-the-npc?c=2011019 🔗 #teamTOMO

Headshots of 102 women and non-binary scientists who are now assistant professors. At the bottom is the Leading Edge logo and www.leadingedgesymposium.org

Leading Edge is celebrating a milestone: 100 (actually 102!) new assistant professors!!! 🎉🥳🎊

Learn more about them:
www.leadingedgesymposium.org/fellows/

Applications are now open for the 2025 Leading Edge cohort! (Deadline Feb 3).

You do NOT need to be ready for the job market to apply.

Direct visualization of electric-field-stimulated ion conduction in a potassium channel Understanding protein function would be facilitated by direct, real-time observation of chemical kinetics in the atomic structure. The selectivity fil…

I had missed this. Looks to be the more interesting paper on the topic in a while.

Using electric-field-stimulated time-resolved X-ray crystallography to investigate K ion movement across the selectivity filter in the well-studied “NaK2K” channel

www.sciencedirect.com/science/arti...

MYO7A is required for the functional integrity of the mechanoelectrical transduction complex in hair cells of the adult cochlea | PNAS Myosin-VIIA (MYO7A) is an unconventional myosin responsible for syndromic (Usher 1B) or nonsyndromic forms of deafness in humans when mutated. In t...

MYO7A, linked to Usher syndrome 1B, is known to localize key bundle proteins - but is this the motor protein responsible for tensioning hair cell tip links? Using a mouse line that enables late, conditional deletion of MYO7A, this work establishes that it is not- shifting focus back to MYO1C.

Towards community-driven visual proteomics! Excited to finally share this large-scale curated & annotated dataset of 1829 high-quality #cryoET tomograms of the little green alga that just keeps giving— Chlamydomonas! 🧪🧶🧬🌾🌊🌍

Preprint📜: www.biorxiv.org/content/10.1...

A short thread🧵👇

De novo design of a voltage gated anion channel.

www.biorxiv.org/content/10.1...

This is clever 👇

My amazing lab went bowling and shared a meal together a couple of weeks ago to celebrate the holidays. And there were soo many treats…Happy holidays to everyone!

🦠A team led by the Lippincott-Schwartz Lab used a new technique developed at Janelia called high-resolution template matching, or HRTM, to uncover in unprecedented detail the movement of ribosomes – the molecular structures that synthesize proteins inside cells.

🔗 hhmi.news/401LKMq

Science’s 2024 Breakthrough of the Year is lenacapavir, an injectable drug that demonstrated remarkable success at preventing HIV infection with one shot every 6 months. The drug attaches to the lattice-like capsid proteins that shield the virus’s genetic material—a mechanism that could inspire other antivirals. Lenacapavir could help end the HIV/AIDS epidemic, but that will hinge on access for those who need it most.

Science’s 2024 Breakthrough of the Year is lenacapavir, an injectable drug that demonstrated remarkable success at preventing HIV infection with one shot every 6 months.

Learn more about this year's #BOTY and other big advances in science: scim.ag/3BrCtUn

I wasn’t sure about the new HHMI initiative at first, but learning that just 10 institutions—led by Stanford, Berkeley, and Rockefeller—account for over half of HHMI’s investigators puts things into perspective. Efforts to improve this aren’t a bad idea!
www.statnews.com/2024/12/13/h...

Filing under TIL... the PDBj mirror of EMPIAR automatically compresses compressible movies (MRC stacks) - meaning in this case only 600GB to download rather than 5.5TB! 😱

Ok I admit it, I used to view this problem as a sign from the Apple Gods to restart my computer … good to know!

In honor of our annual ChemisTree event @hhmi.bsky.social @hhmijanelia.bsky.social today, here's a repost of a little video I made a few years back to demonstrate how the ornament silver plating works! #chemsky

🎉Congratulations to Luke Lavis (@rhodamine110.bsky.social), recipient of the 2025 Gregorio Weber Award for Excellence in Fluorescence Theory and Applications from ISS for his pioneering work on the design & synthesis of small-molecule fluorescent dyes.🧪

We are now accepting applications for speakers from Native American trainees - if you know of someone who would be a good fit, encourage them to apply! More info in the original thread

Apply to be speaker at Full Circle here: forms.gle/dMUtGWvigrNA...
PS: We have travel funds available!
Plz share!

If you want to follow awesome women and non-binary early career scientists, the starter pack of Leading Edge Fellows is here!

go.bsky.app/He3EAcq

🎉 Congratulations to Vivek Jayaraman and Gaby Maimon, co-recipients of the 2024 W. Alden Spencer Award from Columbia University Vagelos College of Physicians and Surgeons for their pioneering contributions in elucidating the neural circuits underlying navigation in fruit flies.

Past and present unite. Quick trip to Janelia with my postdoc, Gufran Siddiqui. Was great to catch up with David Clapham and many others.