Richard A. Amos, CPhys, CSci, FIPEM

It was a pleasure to be organizer and speaker today at the Joint AAPM/EFOMP Session on Particle Therapy at #AAPM2025 @aapmhq.bsky.social

Seeing the next generation of medical physicists being inspired to take the field forward. Also, the beautiful city of Prague, of course.

It was a pleasure to contribute to a successful ESMPE School for Proton Therapy Physics as Scientific Chair and Lecturer these last few days in Prague. #ESMPE #EFOMP

Dose heterogeneity reduces radiation oxygen dependence in both tumor and healthy tissues: the case of proton minibeam radiation therapy Proton minibeam radiation therapy (pMBRT) is an innovative delivery technique characterized by spatially modulated radiation. It was shown to increase the therapeutic index in preclinical glioma model...

Dose heterogeneity reduces radiation oxygen dependence in both tumor and healthy tissues: the case of proton minibeam radiation therapy.
www.redjournal.org/article/S036...

Dubai advances cancer care with first proton therapy centre The UAE’s first proton therapy centre will be built in Dubai, marking a major step forward in cancer treatment in the region.

Proton therapy comes to Dubai.
www.arnnewscentre.ae/en/news/uae/...

Team LhARA at the Great Exhibition Road Festival. (I was not able to join the team as I was attending a conference elsewhere).
#LhARA #GERF

En route to Buenos Aires, Argentina for PTCOG63. Who else will be there?
#PTCOG63

Laser driven FLASH radiobiology using a high dose and ultra high dose rate single pulse proton source - Scientific Reports Scientific Reports - Laser driven FLASH radiobiology using a high dose and ultra high dose rate single pulse proton source

Laser driven FLASH radiobiology using a high dose and ultra high dose rate single pulse proton source: www.nature.com/articles/s41...

<em>Medical Physics</em> | AAPM Journal | Wiley Online Library Background Ultra-high dose rate, or FLASH, radiotherapy has shown promise in preclinical experiments of sparing healthy tissue without compromising tumor control. This “FLASH effect” can compound wi...

Implementation of a novel pencil beam scanning Bragg peak FLASH technique to a commercial treatment planning system aapm.onlinelibrary.wiley.com/doi/full/10....

'Houston will be hit hardest': Researchers in Texas Medical Center brace for impact of Trump NIH cuts TMC could lose millions of dollars in NIH funding raising the threat of job cuts. A legal battle is now expected to end up in the Supreme Court.

Houston will be hit hardest': Researchers in Texas Medical Center brace for impact of Trump NIH cuts
www.khou.com/article/news...

Radiation oncology patients’ perceptions of artificial intelligence and machine learning in cancer care: A multi-centre cross-sectional study The use of artificial intelligence (AI) and machine learning (ML) is increasingly widespread in radiation oncology. However, patient engagement to dat…

Radiation oncology patients’ perceptions of artificial intelligence and machine learning in cancer care: A multi-centre cross-sectional study
www.sciencedirect.com/science/arti...

Very high-energy electrons could prove optimal for FLASH radiotherapy – Physics World THERYQ is developing a radiotherapy system that uses very high-energy electrons to treat deep-seated tumours, and can also enable FLASH treatments

Very high-energy electrons could prove optimal for FLASH radiotherapy
physicsworld.com/a/very-high-...

FLASH Workshop 2025: The Role of Oxygen in FLASH Radiation Therapy
www.dkfz.de/en/biomedica...

How Upright Positioning is Shaping the Future of Proton Therapy Proton therapy is undergoing a revolutionary transformation with the advent of upright patient positioning, promising improved precision and comfort in cancer treatment.

HOW UPRIGHT POSITIONING IS SHAPING THE FUTURE OF PROTON THERAPY
blog.mevion.com/en/blog/how-...

Requirements and study design for the next proton FLASH clinical trials: an international multidisciplinary Delphi consensus Purpose: The FLASH effect, defined as normal tissue sparing while maintaining tumor control with ultra-high dose rate (UHDR) irradiation, has been demonstrated preclinically in different tumors and ti...

Requirements and study design for the next proton FLASH clinical trials: an international multidisciplinary Delphi consensus
@ijrobp.bsky.social www.redjournal.org/article/S036...

Effects of whole brain proton irradiation at conventional or ultra-high dose rate (FLASH), in adult male Sprague Dawley rats - Scientific Reports Scientific Reports - Effects of whole brain proton irradiation at conventional or ultra-high dose rate (FLASH), in adult male Sprague Dawley rats

www.nature.com/articles/s41...

Very much enjoyed giving an invited talk today at the 3rd International Particle Minibeam Therapy (PMBT) Workshop at the National Physical Laboratory (NPL) in the UK. Photo shows a clone of Newton’s apple tree in the grounds of NPL. 🍎
#PMBT2025

Nice to be appreciated….
@ioppublishing.bsky.social

IPEM Reacts to Decision to Abolish NHS England IPEM has released a statement in response to the Government's decision to abolish NHS England

IPEM Reacts to Decision to Abolish NHS England - @ipemnews.bsky.social

www.ipem.ac.uk/news/ipem-re...

IPEM code of practice for proton therapy dosimetry based on the NPL primary standard proton calorimeter calibration service - IOPscienceSearch IPEM code of practice for proton therapy dosimetry based on the NPL primary standard proton calorimeter calibration service, Green, Stuart, Lourenço, Ana, Palmans, Hugo, Lee, Nigel, Amos, Richard A, Souza, Derek D’, Fiorini, Francesca, Van Den Heuvel, Frank, Kacperek, Andrzej, Mackay, Ranald, Pettingell, John, Thomas, Russell

IPEM code of practice for proton therapy dosimetry based on the NPL primary standard proton calorimeter calibration service.
iopscience.iop.org/article/10.1...
@ioppublishing.bsky.social @ipemnews.bsky.social @aapmhq.bsky.social

Carbon minibeam radiation therapy results in tumor growth delay in an osteosarcoma murine model - Scientific Reports Scientific Reports - Carbon minibeam radiation therapy results in tumor growth delay in an osteosarcoma murine model

Carbon minibeam radiation therapy results in tumor growth delay in an osteosarcoma murine model
www.nature.com/articles/s41...

Houston’s MD Anderson, Texas Children’s Hospital announce collaboration to combat childhood cancer | Houston Public Media MD Anderson says the collaborative, set to begin in 2026, will combine the two institutions’ patient populations to “increase pediatric cancer clinical trials.”

Houston’s MD Anderson, Texas Children’s Hospital announce collaboration to combat childhood cancer
www.houstonpublicmedia.org/articles/new...

Trump 2.0: an assault on science anywhere is an assault on science everywhere US President Donald Trump is taking a wrecking ball to science and to international institutions. The global research community must take a stand against these attacks.

Trump 2.0: an assault on science anywhere is an assault on science everywhere
www.nature.com/articles/d41...

<em>Medical Physics</em> | AAPM Journal | Wiley Online Library Background Boron Neutron Capture Therapy (BNCT) is a binary radiotherapy based on the intravenous administration of a borated drug to the patient and the subsequent irradiation with a low-energy neu...

Towards an adequate description of the dose-response relationship in BNCT of glioblastoma multiforme
aapm.onlinelibrary.wiley.com/doi/10.1002/...

Aberrant choroid plexus formation drives the development of treatment-related brain toxicity - Communications Biology Human cerebral organoids provide insights into mechanisms behind the formation of choroid plexus (CP)-like structures that may contribute to radiation-induced brain image changes.

Aberrant choroid plexus formation drives the development of treatment-related brain toxicity
www.nature.com/articles/s42...

FLASH radiation reprograms lipid metabolism and macrophage immunity and sensitizes medulloblastoma to CAR-T cell therapy - Nature Cancer Fan and colleagues show that FLASH radiation promotes proinflammatory polarization of tumor-associated macrophages, which in turn increases T cell influx in medulloblastoma and synergizes with CAR-T c...

FLASH radiation reprograms lipid metabolism and macrophage immunity and sensitizes medulloblastoma to CAR-T cell therapy
www.nature.com/articles/s43...

On the significance of peak dose in normal tissue toxicity in spatially fractionated radiotherapy: The case of proton minibeam radiation therapy Proton minibeam radiation therapy (pMBRT) [1] is a type of spatially fractionated radiation therapy (SFRT) [2], which uses submillimetric (0.5–1.0 mm) proton beams spaced by 1.0 to 4.0 mm. The dose pr...

On the significance of peak dose in normal tissue toxicity in spatially fractionated radiotherapy: The case of proton minibeam radiation therapy
www.thegreenjournal.com/article/S016...

Differentiating unirradiated mice from those exposed to conventional or FLASH radiotherapy using MRI Background and purpose: The FLASH effect expands the therapeutic ratio of tumor control to normal tissue toxicity observed after delivery of ultra-high (>100 Gy/s FLASH-RT) vs. conventional dose rate ...

Differentiating unirradiated mice from those exposed to conventional or FLASH radiotherapy using MRI
www.biorxiv.org/content/10.1...

Multidisciplinary Collaboration and Novel Technological Advances in Hadron Therapy - Manjit Dosanjh, Alberto Degiovanni, Maria Monica Necchi, Elena Benedetto, 2025 The battle against cancer remains a top priority for society, with an urgent need to develop therapies capable of targeting challenging tumours while preserving...

Multidisciplinary Collaboration and Novel Technological Advances in Hadron Therapy
journals.sagepub.com/doi/10.1177/...

FLASH radiation reprograms lipid metabolism and macrophage immunity and sensitizes medulloblastoma to CAR-T cell therapy - Nature Cancer Fan and colleagues show that FLASH radiation promotes proinflammatory polarization of tumor-associated macrophages, which in turn increases T cell influx in medulloblastoma and synergizes with CAR-T c...

FLASH radiation reprograms lipid metabolism and macrophage immunity and sensitizes medulloblastoma to CAR-T cell therapy
www.nature.com/articles/s43...