Marcus Ruscetti Lab

Read the Letter Researchers at academic institutions nationwide say that U.S. science is being dismantled.

www.nytimes.com/interactive/...

31.03.2025 22:55 — 👍 42    🔁 26    💬 4    📌 1

Why do we even have to do this? I wondered the whole time at Stand for Science. 🧪 But it was inspiring to see so many people committed to fighting for truth, science, and justice!

07.03.2025 22:11 — 👍 190    🔁 22    💬 6    📌 1

#standupforscience Boston

07.03.2025 21:53 — 👍 23    🔁 3    💬 0    📌 0

Congrats to Haruka from the Atukorale and Ruscetti labs for passing her qualifying exam to become a Ph.D. candidate yesterday! We are proud mentors and can't wait to see what you can accomplish through engineering LNPs for drug delivery in pancreatic cancer!

07.03.2025 02:25 — 👍 1    🔁 0    💬 0    📌 0

Identifying specific functional roles for senescence across cell types A dual recombinase-mediated genetic system for cell-type-specific lineage tracing, ablation, and gene manipulation of senescent cells reveals distinct roles of senescence across cell types.

Original article here:

www.cell.com/cell/fulltex...

07.01.2025 16:53 — 👍 1    🔁 0    💬 0    📌 0

Lineage tracing senescence in vivo shows not all senescent cells are created equal Understanding the impact of senescence on disease is limited by the lack of tools to lineage label senescent cells. In a recent Cell issue, Zhao et al. create mouse models to genetically manipulate and trace p16+ cells, identifying contrasting roles for senescent macrophages and endothelial cells (ECs) in liver fibrosis.

Happy to highlight work from Zhao et al., who developed 4! new mouse models to trace and genetically manipulate different p16+ senescent cell types that will be invaluable to the field. Check out my spotlight @Dev_Cell and original article in @cellcellpress.bsky.social
www.cell.com/developmenta...

07.01.2025 16:53 — 👍 3    🔁 0    💬 1    📌 0

Cellular senescence offers distinct immunological vulnerabilities in cancer Chronic damage following oncogene induction or cancer therapy can produce cellular senescence. Senescent cells not only exit the cell cycle but communicate damage signals to their environment that can trigger immune responses. Recent work has revealed that senescent tumor cells are highly immunogenic, leading to new ways to activate antitumor immunosurveillance and potentiate T cell-directed immunotherapies. However, other studies have determined that heterogeneous senescent stromal cell populations contribute to immunosuppression and tumor progression, sparking the development of senotherapeutics to target senescent cells that evade immune detection. We review current findings that provide deeper insights into the mechanisms contributing to the dichotomous role of senescence in immune modulation and how that can be leveraged for cancer immunotherapy.

Happy to share our recent review on cellular senescence and its impact on tumor immune surveillance authored by Lin Zhou and Boyang Ma in the lab, out now online at Trends in Cancer. Lots of exciting developments in the field over the past few years worth checking out!
www.cell.com/trends/cance...

02.01.2025 16:20 — 👍 9    🔁 0    💬 0    📌 0

Lab Holiday party

Always wonderful to see how our lab family grows each year. Happy Holidays from the Ruscetti and @pitarresilab.bsky.social groups!

21.12.2024 16:21 — 👍 4    🔁 0    💬 0    📌 0

Engineered extrachromosomal oncogene amplifications promote tumorigenesis - Nature Large extrachromosomal DNAs are engineered using a CRISPR- and Cre–loxP-based approach and shown to drive cancer in mouse models, with potential applications in determining the role of oncogene a...

🧪1/ 🚨New paper on ecDNAs from our lab!
We reveal a strategy to engineer extrachromosomal DNA (ecDNA) amplifications in cells & mice. Let's dive in! Let’s dive in! 🧵👇
www.nature.com/articles/s41...

18.12.2024 16:54 — 👍 116    🔁 43    💬 12    📌 8

Ruscetti lab group photo September 2024

First post on @bsky.app! Excited to engage with the scientific community, share our lab's research on tumor immunology and cellular senescence, and highlight the work and accomplishments of our inspiring lab members on this platform.

05.12.2024 02:52 — 👍 45    🔁 3    💬 2    📌 0

Cell polarity proteins promote macropinocytosis in response to metabolic stress - Nature Communications Cancer cells rely on macropinocytosis to survive in a nutrient-deprived environment. Here, Lambies et al. identified various members of the cell polarity protein network as essential regulators of mac...

I'm thrilled to share our latest research, published in Nature Communications. This work highlights how pancreatic cancer cells hijack cell polarity proteins to regulate macropinocytosis and tumor metabolism, shedding light on potential therapeutic vulnerabilities.
www.nature.com/articles/s41...

04.12.2024 00:52 — 👍 70    🔁 16    💬 4    📌 0

No better 1st post on this platform than this - the Pitarresi and Ruscetti labs at UMass Chan raising awareness on World Pancreas Cancer Day. Surely a long way to go but fueled by a singular purpose of defeating this deadly malignancy!

21.11.2024 19:29 — 👍 5    🔁 1    💬 0    📌 0