Tony Bruns (Bruns Lab Aachen)

At the beautiful European mucosal immunology group conference #emig in Aachen ready for two days of great #mucosalimmunology sciences #interferosky #gastrosky 🧪

🔥 We’ve hit 50% recruitment in the #COMBATtrial!
Huge thanks to all involved!💙
@rautoupe.bsky.social @hopitalbeaujon.bsky.social @hospitalclinic.bsky.social @rwth.bsky.social @uni-muenster.de @brunslab.bsky.social @medblab.bsky.social @frankuschner.bsky.social

#LiverSky #ClinicalTrial

a woman wearing glasses and a red jacket

Check out this electric insight from our Rising Star 2025, Carolin Schneider!
⭐ UEG Rising Star Awards are annually given to 10 of the most promising, emerging scientists. 🏆
🏆 Access Carolin's publication: https://bit.ly/3DDKzdX
#myUEGcommunity

💉 Albumin duration & AKI response in cirrhosis
Eva M. Schleicher (Mainz) – #EASL2025
🕒 24h albumin new rule questioned
🏆 EASL AKI response definition wins
📈 20% of 24h NR improved at 48h
⚖️ Early vs late responders: Same mortality
🚨 Cr ↑ >16% @24h → terlipressin!
👇

Back in the Abstract Session: Theresa Wirtz presents her scRNA-seq work on monocyte subsets and ACLF risk.

@rwth.bsky.social
@brunslab.bsky.social
@easlnews.bsky.social

#Cirrhosis #ACLF #EASL2025"

🦠The recovery failure of fecal microbiota diversity in patients after liver transplant is associated with a complicated postoperative course

#POSTER SAT-518 by @beccsipollsi.bsky.social from @rwth.bsky.social at #EASL2025

@brunslab.bsky.social
@easlnews.bsky.social

Congrats on presenting your poster in the Track Hub 4 this afternoon, @beccsipollsi.bsky.social ! 🙌

Next at the DECISION Networking Session at #EASL2025, Theresa Wirtz (UKA) presents scRNA-seq data showing a monocyte subset linked to ACLF risk.
Fascinating translational science in action!
@brunslab.bsky.social ky.social @easlnews.bsky.social ky.social

#scRNAseq #ACLF

Global epidemiology of acute kidney injury in hospitalised patients with decompensated cirrhosis: the International Club of Ascites GLOBAL AKI prospective, multicentre, cohort study This study found important regional differences in AKI severity, phenotype, management, and outcomes in patients with decompensated cirrhosis. Health-care coverage remains an important driver of survi...

📣 ICA GLOBAL AKI study published in @lancetgastrohep.bsky.social

🗺️3,821 patients with cirrhosis
✅38% had AKI
⚠️discrepancies in AKI management and outcomes
⚠️ AKI ➡️22.9% 28-day mortality

🎯Need for equitable & standardized care

www.thelancet.com/journals/lan...

The non-canonical inflammasome activators Caspase-4 and Caspase-5 are differentially regulated durin... The non-canonical inflammasome, which includes caspase-11 in mice and caspase-4 and caspase-5 in humans, is upregulated during inflammatory processes and activated in response to bacterial infections ...

Immunology research on bacterial infections in patients with cirrhosis: The human inflammatory caspases 4 and 5 are differentially regulated in patients with immune dysfunction due to sepsis and In acute-on-chronic liver failure. www.frontiersin.org/articles/10....