Mark Rossi

🚨 New preprint from an ongoing collaboration with the Pang lab. Project led by rising stars @rohansavani.bsky.social and @lewang1.bsky.social showing how individual GLP-1R neurons in the paraventricular hypothalamus track ingestion across energy states.

Preprint: papers.ssrn.com/sol3/papers....

The posting is now live. Apply today to join our group as a research assistant. Perfect for a recent grad looking to go to grad/med school. Message me for more info. Apply here: jobs.rutgers.edu/postings/256...

A simple action reduces high-fat diet intake and obesity in mice Diets that are high in fat cause overeating and weight gain in multiple species of animals, suggesting that high dietary fat is sufficient to cause ob…

This was a really fun project: We blocked obesity in mice by making them do a tiny bit of work for their food. www.sciencedirect.com/science/arti...

We are hiring a new research assistant! Official job post to follow. Please reach out or visit markrossilab.org if you are interested.

Two Rutgers Teams Trace Brain Circuits That Tell Us When to Eat – and When to Stop Back-to-back studies map complementary hunger and satiety pathways, offering clues to refine weight-loss drugs.

A nice write up about the new work coming out of the Rutgers Center for NeuroMetabolism www.rutgers.edu/news/two-rut...

Opioid-driven disruption of the septum reveals a role for neurotensin-expressing neurons in withdrawal Opioid withdrawal produces a dysphoric state that can lead to relapse. Simon et al. reveal that lateral septal neurotensin-expressing neurons are selectively activated by naloxone and drive changes in...

Thrilled to announce that our paper is now finally out! 🎉We combine scRNAseq, 2p imaging, ephys, and behavior to understand the role of lateral septal Nts neurons in opioid withdrawal. Curious about the septum and addiction? Give it a read👇

www.cell.com/neuron/fullt...

This was a team effort from everyone in the lab. A huge thank you to all involved. The project was made possible by generous support from the NIH.
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These processes are influenced by hunger and satiety hormones, which modulate the BNST→LHA pathway to align food-seeking behavior with current energy needs.
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We found that synaptic strength and neuronal function within this pathway are dynamically regulated based on the animal’s energy state, guiding reward-seeking behavior accordingly.
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Using a combination of optogenetics, in vivo 2p calcium imaging, and electrophysiology, we show that the BNST→LHA pathway promotes reward seeking in an energy state-dependent manner.
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We focused on the GABAergic pathway from the bed nucleus of the stria terminalis (BNST) to glutamatergic neurons of the lateral hypothalamic area (LHA), specifically examining how this circuit modulates reward-seeking behavior based on energy state.
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Energy state guides reward seeking via an extended amygdala to lateral hypothalamus pathway - Nature Communications The lateral hypothalamic area (LHA) mediates reward seeking. Here, the authors show how LHA afferent connections promote reward seeking by shaping synaptic strength according to energy state, processe...

Excited to share our latest paper led by Kuldeep Shrivastava out now in @natcomms.nature.com
www.nature.com/articles/s41...
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The new Rutgers Center for NeuroMetabolism is officially hiring faculty at all levels! Come be my colleague!

jobs.rutgers.edu/postings/248...

RWJMS Center for NeuroMetabolism Research Fund | Support Rutgers University Foundationlabel.header.loginSubmit search keywordsSubmit search keywordsView CartView CartsearchView CartSubmit search keywo... The Rutgers Center for NeuroMetabolism (CNM), a division of the Child Health Institute of New Jersey, is a world-renowned leader in researching the neurological aspects of metabolic health and disease...

Now is a great time to support basic research. Consider making a donation to the newly established Rutgers Center for Neurometabolism for giving day. Donations will support our wonderful trainees as they navigate a challenging funding landscape give.rutgersfoundation.org/neurometabol...

Rutgers Launches Center to Tackle Barriers to Weight Loss and Other Causes of Disease

Big things happening at the new Rutgers Center for NeuroMetabolism! www.rutgers.edu/news/rutgers...

There's still time to apply. Come present your work at Rutgers!

2025 BHI Postdoc Recruitment Event - BHI

The Brain Health Institute at Rutgers is hosting a postdoc recruitment event April 22-23. Grad students and postdocs looking for postdoc positions, apply today to present your work, network with colleagues, and connect with potential mentors. brainhealthinstitute.rutgers.edu/2025-bhi-pos...

PhD or post doc? attending a meeting about metabolism in 2025? Need some financial support? Consider applying for one of these travel grants from @lifemetabolism.bsky.social 750 US$ for a half page application.

Glp1r-Lepr coexpressing neurons modulate the suppression of food intake and body weight by a GLP-1/leptin dual agonist Orthogonal murine models demonstrate the bioactivity and neuronal targets of a GLP-1/leptin coagonist in relation to food intake and body weight.

Latest from our group in collaboration with Lotte Bjerre Knudsen and other Novo scientists. They developed a GLP-1/Leptin co-agonist that we put through its paces in a number of mouse models to prove that both parts of the molecule matter. More options on the table!
www.science.org/doi/10.1126/...

Molecular connectomics reveals a glucagon-like peptide 1-sensitive neural circuit for satiety Nature Metabolism - Combining rabies-based connectomics with single-nucleus transcriptomics, the authors identify a neural circuit through which GLP-1 receptor agonists suppress appetite in mice.

New work stemming from an amazing collaboration with @addisonwebster0 and @AUGCsoup using a combination of rabies mapping and single cell sequencing to identify a GLP1R-expressing local input to AgRP cells that curbs appetite rdcu.be/d2gB5

The deadline to apply to our Cell Biology, Neuroscience and Physiology (CBNP) PhD program is January 3 for in person interviews. Better to apply earlier as in person slots tend to fill up sooner.
njms.rutgers.edu/sgs/prospect...

Excited to share my contribution to this free to all, open access Behavioral Neuroscience textbook including the FIRST EVER Neuroimmunology chapter! please share and let us know what you think.

OPEN RANK #FACULTY #POSITION in #Pharmacology & #Neuroscience with expertise in #behavioral pharmacology/neuroscience of relevance to substance use disorders. Review of applications will start immediately. Target start date is Fall 2025. Come join us!

Apply here: careers.umich.edu/job_detail/2...