Matthias D'hooghe

Our review paper on the synthesis and antibacterial properties of C4-functionalized β-lactams is published in @wiley.com: doi.org/10.1002/cmdc... @synbioc.bsky.social @fbwugent.bsky.social @chsteven.bsky.social

Our PhD student Ulrike Ronse presenting a decade of work on HDAC6 in our group at the Medicinal Chemistry Frontiers conference 2025 in Chicago 😀 @synbioc.bsky.social @fbwugent.bsky.social

Check out our new paper on 3-imino-β-lactam chemistry, published in J. Org. Chem.: pubs.acs.org/doi/full/10....
@pubs.acs.org @synbioc.bsky.social @chsteven.bsky.social
@fbwugent.bsky.social

#SynBioC Proud about our SynBioC team who participated at the Sofico Ghent Half Marathon last Sunday! We love: "Work hard, play hard" @chsteven.bsky.social @dhooghe-group.bsky.social @smangelinckx.bsky.social @thegreenchemlab.bsky.social

Get to know our enthousiastic SynBioC research group @chsteven.bsky.social @dhooghe-group.bsky.social @smangelinckx.bsky.social @thegreenchemlab.bsky.social

The varieties of VHL linker experience Or why meticulous experimental and computational characterization are integral to good PROTAC design

New post: I wrote about a recent PROTAC linker design study that drives home the thoroughness with which you have to experimentally and computationally investigate linker flexibility and properties. It's a great role model for practitioners in the field. medchemash.substack.com/p/the-variet...

Sustainable chemistry: producing molecules more environmentally friendly Researchers from the University of Bern and the RIKEN research institute in Japan have made a significant advance in sustainable chemistry. They have succeeded in producing organic molecules through a...

Significant progress in sustainable chemistry: researchers from the #unibern and the RIKEN Institute have been able to produce organic #molecules using a chemical reaction based on the sustainable metals #sodium and #iron: mediarelations.unibe.ch/media_releas... @evaheviagroup.bsky.social

New paper! Our work on cancer cell cytotoxic benzothiazepanes (part 3), in collaboration with the Rega Institute @kuleuven.bsky.social, is published in J. Heterocyclic Chem.: dx.doi.org/10.1002/jhet... @fbwugent.bsky.social @wiley.com #curcumin

New Paper Alert! See our joint SynBioC – VIB-CMB work on #HDAC6 ubiquitin-binding domain inhibitors published in Eur. J. Med. Chem. doi.org/10.1016/j.ej... @elsevierconnect.bsky.social, with @rjharding.bsky.social, KU Leuven, @csbugent.bsky.social, K. Van Hecke. @fbwugent.bsky.social

This #OrgLett cover by Guillermo Correa Otero demonstrates human error in mass spec report checking. Instead use CheckAMM!

Editorial by EIC Marisa Kozlowski introducing CheckAMM:
pubs.acs.org/doi/10.1021/...

What @christmann.bsky.social found checking AMM reports:
pubs.acs.org/doi/10.1021/...

The costs of competition in distributing scarce research funds | PNAS Research funding systems fundamentally influence how science operates. This paper aims to analyze the allocation of competitive research funding fr...

Researchers spend approximately 45% of their time on administrative activities related to #grants rather than actual #research. The current #competition in research #funding has significant drawbacks; evidence-based improvements of the funding system are required: www.pnas.org/doi/10.1073/...

Teambuilding activity at the Christmas market in Ghent 😀

Congratulations to our new SynBioC doctor Katarina Magdalenic for the excellent work on curcuminoids, and many thanks to Prof. Zrinka Rajic from the University of Zagreb for acting as an external jury member!

It was a pleasure to host Prof. Annette Bayer from the Artic University of Norway today, who gave a very inspiring lecture about stereoselective CO2 fixation and beta-lactamase inhibitor design