Nazgul Sakenova

Excited to share our preprint led by Carlos Voogdt et al

We developed new genetic tools & genome-wide libraries for species of the Bacteroidales order; constructed saturated barcoded transposon libraries in key representatives of three genera.
www.biorxiv.org/content/10.1...

Congrats! Nice to see it published!

From Fellowship to Frontline: Camille Goemans’ Mission to Tackle Antibiotic Resistance – People – EMBO An interview with Camille Goemans, tenure-track assistant professor at the École Polytechnique Fédérale de Lausanne (EPFL) in Lausanne, Switzerland and former EMBO Postdoctoral Fellow

How the @embo.org postdoctoral fellowship helped me in developing my academic career... happy to see my profile featured on the EMBO website!
www.embo.org/people/from-...

Most bacterial gene families are biased toward specific chromosomal positions The arrangement of genes along bacterial chromosomes influences their expression through growth rate–dependent gene copy number changes during DNA replication. Although translation- and transcription-...

I was waiting two years to see this out!! The genomic location of bacterial genes is not random!!! Congratulation on the authors (Martin Lercher and Team!). www.science.org/doi/10.1126/...

I attended the course in 2022, as it’s held every three years. It combines diverse, exciting science with close-knit socializing on a beautiful Greek island.

Highly recommended for PhD students at any stage!

@typaslab.bsky.social

Resistance to one antibiotic can make bacteria resistant or sensitive to another antibiotic, opening paths for combinatorial treatments. A study in Nature Microbiology presents an approach to systematically discover and understand such antibiotic relationships. https://go.nature.com/49of3Mk 🧪

(1/3) Antibiotic resistance is costing human lives. 🦠
A study from EMBL's Typas group proposed a framework to identify antibiotic pairs that make bacteria resistant to one antibiotic but sensitive to other – this can help design new treatments and delay resistance. 🧬🧪

www.nature.com/articles/s41...

My PhD work is now published in Nature Microbiology! Please, have a look!

We present a framework for faster, cheaper and systematic antibiotic XR & CS discovery with chemical genetics, mechanism deconvolution, and reduction of resistance evolution, paving the way for rationally designed treatments. Thanks to @elisca.bsky.social @typaslab.bsky.social and everyone involved!

Antibiotic (abx) resistance is outpacing new abx discovery. This is worsened by cross-resistance (XR) between abx. However, resistance can also lead to collateral sensitivity (CS) to other abx, providing new treatment opportunities. In our new preprint www.biorxiv.org/content/10.1...