@marcusbuschbeck.bsky.social
Senior Group Leader at Josep Carreras Institute. Chromatin; Nucleal metabolism; Leukemia; MDS; Drug Targets; Histone variants. Posting about the lab and the wider scientific community. More info about us here: www.buschbecklab.org
Great opportunity for Senescence aficionados to share results and network in Spain's most beautiful university town!
Check out the new profile page of the lab on LinkedIN!
We will post news about:
- Changes in the team composition
- Opportunities
- Where to meet us
- Preprints, publications and theses
Indeed, we have been growing. Find out more here:
www.linkedin.com/company/busc...
As 2025 comes to a close, my university (Dalhousie U in Halifax, Canada) is recruiting faculty, including outstanding early career researchers, and Canada Research Chairs. Applications are due January 19 2026 (was just notified today!). Please repost.
Ten days left to apply to be a @crick.ac.uk Early Career Group Leader
Closing date 27th November
www.crick.ac.uk/careers-stud...
Last opportunity to join the NUCLEAR network as PhD student in a Biotech environment!
Last opportunity to join the NUCLEAR network as PhD student!
OFERTA DE EMPLEO (por favor difundir):
Ofrecemos un contrato predoctoral de 4 años asociado a nuestro proyecto PID2024-157249OB-I00. El objetivo del proyecto es evaluar un nuevo mecanismo patológico según el cual la competición entre promotores puede llegar a ocasionar enfermedades congénitas
👇
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We would like to thank:
- Our collaborators from the teams of Emily Bernstein, Manlio Vinciguerra and
@poberdoerffer.bsky.social for advice and samples.
- Our editor Navdeep Chandel for his guidance.
- And most importantly, all members of my lab for support on all levels.
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Conclusion: Chromatin composition integrates with metabolic regulation at the NAD⁺ interface. Loss of macroH2A1.1 decouples chromatin–mitochondrial crosstalk, shifting nutrient flux toward glycolysis and instigating secondary organ dysfunction.
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A ketogenic diet, enforcing lipid oxidation and lowering NAD⁺ demand, normalized RER, glucose tolerance, and liver gene profiles, completely preventing kidney abnormalities. Thus, diet overrode the metabolic phenotype associated with macroH2A1.1 loss.
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This was secondary to a systemic shift in metabolism. Respiratory exchange measurements (RER) indicated reduced oxidation of lipids and increased glucose utilization — consistent with a Warburg-like shift. This was accompanied by alterations in NAD+ metabolism.
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Mice lacking macroH2A1.1—but not macroH2A1.2 or macroH2A2—developed inflammatory lesions and hyaline casts in kidneys of both sexes, independent of local transcriptomic changes, implicating systemic rather than renal-intrinsic dysfunction.
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This is the product of team effort coordinated by René Winkler. A decade of collaboration between our group and the team of Raffaele Teperino @epitep.bsky.social and the German Mouse Clinic led by Martin Hrabě de Angelis @helmholtzmunich.bsky.social.
NEW PAPER
Out in Science Advances: We have dissected the physiological role of all macroH2A histone variants. In mice, loss of macroH2A1.1 specifically results in profound metabolic reprogramming and kidney pathology.
DOI: 10.1126/sciadv.adz1242
Thread 1/7
True in 9 out of 10 cases.
MEET THE LAB!
This week our postdoc René Winkler will attend the @febspress.bsky.social workshop 'Molecular and cellular pathways of aging in hematopoiesis' on Crete, Greece.
René will present work led by @shubhra.bsky.social on how cohesin mutations impact MDS progression.
MEET THE LAB
Today Marina Farkas is attending the "Molecular Haemopoiesis" meeting at the Francis Crick Institute in London, UK.
A gathering of researchers studying #blood development, with a particular focus on blood stem cell biology, gene regulation and #leukaemia.
We are recuiting two new Associate Professors here in Oxford Biochemistry. Come join us! Reach out to me if you have any questions. Please repost! tinyurl.com/mr3m7bd3
Adios and salut to a pioneer!
Sir John Gurdon studied the requirements and barriers of #reprogramming.
Highly relevant for us, with his PhD student Vincent Pasque he showed that macroH2A is part of the epigenetic barrier inhibiting reprogramming.
Our thoughts are with his family and friends.
NEW TEAM MEMBER!
We welcome Bedri Batuhan Yaman to the group. Bedri will study the role of nuclear metabolism in #AML. He is co-supervised by @florherbstein.bsky.social and fellow of the MSCA @nucleardn.bsky.social.
Bedri is alumnus of @viblifesciences.bsky.social (Belgium) and NeuroBM (Turkey).
Looking for scientists working with long-read transcriptomics technologies to join a COST action proposal. Contact us!!! @nanoporetech.com @pacbio.bsky.social
We have a new PhD studentship in the lab on the immunogenic roles of transposable elements in paediatric acute myeloid leukaemia! Come and work with us! www.colcc.ac.uk/2026-cyp-phd...
FAREWELL!
After 6 month of Master research, Francesco B. Ciriscioli is returning to his home university in Triest, Italy.
Thank you, Francesco, for your interesting results and for having enriched our group with your kind personality. We wish you all the best!
Great weather at daytime and northern lights at night time illuminate the scientific kick-off of the #HubMOL #MSCA doctoral network. On Someroy, a small island at the Artic Coast of Norway, we learn about the dual role of molecules such as NAD and SAM in signalling and metabolism.
MEET THE LAB!
During the next 3 days, I am in northern Norway at the kick-off workshop of the HubMOL consortium. This MSCA doctoral network coordinated by Ines Heiland, University of Tromsø, aims to gain a better understanding of the dual role of NAD, CoA and co. in metabolism and signalling.
What a great first day at the GfG symposium on epigenetics & chromatin. Fantastic talks by @akispapantonis.bsky.social , @apombo1.bsky.social, @marcusbuschbeck.bsky.social and Philipp Korber. And Peter Becker giving the Max-Delbrueck lecture. A real treat for the audience!
NEW DOCTOR IN TOWN!
Congratulations to Lejuan Shi from Sonia Forcales' lab who has defended her thesis today.
As chair of her defense committee with Concepcio Soler and @tanyavavouri.bsky.social, I had the opportunity to discuss with Lejuan about the role of lncRNAs in cancer.
NEW LAB MEMBER!
We welcome @florherbstein.bsky.social who is joining us as a @carrerasleaders.bsky.social Postdoctoral Fellow. She is alumni of #IBioBA-MPSP and the University of Buenos Aires.
She will study how nuclear metabolism influences proliferation and therapy resistance in AML.
Thank you, Manfred.
