Some great presentations at the DBS 3rd Expert Summit. And then there's @barbarahollunder.bsky.social absolutely knocking it out of the park! So cool to see her work shine doi.org/10.1038/s41593-024-01570-1
Thank you so much for the shout-out!
Uncovering the Neural Fingerprint of Akinetic States in a Parkinsons Disease Rodent Model https://www.biorxiv.org/content/10.1101/2025.04.22.650006v1
💾 paper code : github.com/ELGarulli/ak...
👩💻 neurokin : github.com/ELGarulli/ne...
👨💻 py_neuromodulation : github.com/neuromodulat...
🗝️ Takeaways:
- β‑band modulates during akinesia - expected - but so do Hjorth complexity & mobility, simple time‑domain metrics!
- They are computationally light & may be future closed‑loop DBS biomarkers!
- neurokin is now available to support neurobehaviour analysis and custom feature extraction
🔍 How?
- We captured 3D kinematics and MTCx ECoG during a runway task in 6‑OHDA rats
- Extracted kinematic features using our new open‑source toolbox #neurokin and neural features using #py_neuromodulation
- Applied LDA and #CEBRA to pinpoint features that distinguish akinesia
Preprint alert 📢 looking for akinesia fingerprints 🧐
www.biorxiv.org/content/10.1...
🔍 How?
- We captured 3D kinematics and MTCx ECoG during a runway task in 6‑OHDA rats
- Extracted kinematic features using our new open‑source toolbox hashtag#neurokin and neural features using hashtag#py_neuromodulation
- Applied LDA and hashtag#CEBRA to pinpoint features that distinguish akinesia
