Philip Dunne

Epithelial GREMLIN1 disrupts intestinal epithelial-mesenchymal crosstalk to induce a wnt-dependent ectopic stem cell niche through stromal remodelling - Nature Communications The authors show that aberrant epithelial GREM1 expression remodels intestinal stroma to form ectopic stem cell niches in mice. Anti-GREM1 reversed these changes, highlighting a potential strategy for...

Finally out! A longstanding project to explore the mechanism behind ectopic crypt formation in polyps when GREM1 is aberrantly expressed in HMPS patients. Turns out it is all to do with stromal remodelling and epithelial-mesenchymal interdependence!
www.nature.com/articles/s41...

Defining the mucosal ecosystem: epithelial–mesenchymal interdependence in gastrointestinal health and disease - Nature Reviews Gastroenterology & Hepatology This Review focuses on epithelial–mesenchymal crosstalk and how these interactions shape development, health and disease in the intestinal mucosa. The dynamic nature of this ecosystem is highlighted, ...

New review on the importance of intestinal epithelial-mesenchymal crosstalk - from development and homeostasis through to regeneration to neoplasia. Excellent collaboration with Frances England, Manquiang Lin and Michael Sigal

www.nature.com/articles/s41...

Uridine phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes | EMBO reports imageimageMetastatic primary tumours upregulate Upp1 in neutrophils, which elevates circulating uracil. UPP1-expressing neutrophils accumulate in the lung where they inhibit CD8+ T cells, promote fibronectin deposition and support metastatic niche ...

And the original publication is here:
Uridine phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes | EMBO reports share.google/JXMzGDRzpl0E...

YouTube video by Fiona MacLeod Dr Cassie Clarke CRUK Scotland Institute - breast cancer research

It was a pleasure to speak to Lucy Whyte this morning on #BBCRadioScotland to discuss our recent @emboreports.org publication which has discovered how #neutrophil #metabolism facilitates #metastasis. Catch up with interview here: www.youtube.com/watch?v=tUUw...

✨Thrilled to announce an exciting opportunity to work on our project exploring WNT-driven cell competition as a novel preventative strategy in CRC 🧬

We’re hiring a Senior Scientific Officer to join me in @owen_sansom’s lab. Great science and lots of room to make an impact! 👩🏽‍🔬

Excellent opportunity to work with a wonderful team 👇👇💥

We are recruiting a Senior Scientific Officer to work with @nadianasreddin.bsky.social in the Sansom lab on the project WNT-driven cell competition: a target for novel preventative strategies against colorectal adenoma formation

📅Apply by 15 August 2025

www.crukscotlandinstitute.ac.uk/careers/

Sunshine and science in Glasgow today at the CRC-STARS kick off meeting

Excellent presention from Raheleh in our team charting phenotypic evolution during cancer development and progression, and how best we can use preclinical models of cancer to improve patient outcomes

AACR.. over and out! Great couple of days in Chicago, brilliant to catch up with so many collaborators and make new connections. Coming home brimming with new ideas to take into our @cruk-si.bsky.social early detection, @incise-research.bsky.social, & CRC-STARS programmes

#AACR25

Incredibly proud to see Dr Fisher presenting her research at the @theaacr.bsky.social annual conference.

Understanding precancer biology is crucial for improving early detection, and preventing early cancer development and progression.

#AACR25

@nataliefisher.bsky.social

Session with Natalie’s talk starting shortly in room E351

bsky.app/profile/s-j-...

Yes! - we are hiring @yale.edu - links below...

@cruk-si.bsky.social @qubelfastofficial.bsky.social @cancerresearchuk.org @incise-research.bsky.social @joedwardswwcrc.bsky.social

If you are Chicago bound watch out for Natalie & Sid presenting at #AACR2025 & come say hello!

Natalie's @theaacr.bsky.social Women in Cancer Research award talk covers how we can use biology to improve early detection of polyps

Sid's poster is on early tumour transcriptional landscapes

Bowel Cancer in the Spotlight as Network Members Lead New Research Towards Personalised Treatment | National Mouse Genetics Network MRC National Mouse Genetics Network (NMGN) members from the Cancer Cluster and the new Data Platform initiative are at the centre of a new project announced on the 31st of […]

Network members secure new #funding aimed at developing new and personalised #therapeutic approaches for #ColorectalCancer nmgn.mrc.ukri.org?p=1808&previ... @drpipdunne.bsky.social @cancerresearchuk.org @cruk-si.bsky.social

Members of IMPACT span wet-lab scientists, pathologists, bioinformaticians, patient involvement managers, image analysts, technicians, clinicians, students, project managers, and lecturers among others, to ensure a wide range of expertise and optimum resource management!

With 5 distinct research groups led by @joedwardswwcrc.bsky.social, Campbell Roxburgh, Nigel Jamieson, Colin Steele, and @mcsorleystephen.bsky.social, IMPACT provides a human tissue-based translational research infrastructure in Glasgow, in collaboration with @drpipdunne.bsky.social and Xiao Fu! 🤝

Last week, the 1st Annual IMPACT conference took place on the shores of Loch Lomond 📍🤩

An absolutely brilliant few days in sunny Loch Lomond with my Glasgow colleagues 🏴󠁧󠁢󠁳󠁣󠁴󠁿☘️☀️

Many thanks WntUK ECR rep @nadianasreddin.bsky.social from @cruk-si.bsky.social for chairing the Future Generation session!

#WNTUK2025

Such an honour! Thank you to the organising committee for the opportunity and the great conference!!

The tumor microenvironment is an ecosystem sustained by metabolic interactions Cancer-associated fibroblasts and immune cells are known to interact within the tumor microenvironment and influence each other to impact on tumor progression. Here, Kay et al. discuss how they can al...

Congrats to @zanivanlab.bsky.social for this very interesting review: www.cell.com/cell-reports...

A St Patrick’s Day treat ☘️

More excellent work from @aideenryan.bsky.social and her team, teasing apart the importance of stromal & immune communication networks in colorectal cancer 👇

Stromal cells modulate innate immune cell phenotype and function in colorectal cancer via the Sialic acid/Siglec axis https://www.biorxiv.org/content/10.1101/2025.03.14.642985v1

Data Scientist in Sutton | The Institute of Cancer Research View details and apply for this Data Scientist vacancy in Sutton. Salary Range: Commencement on the salary range is subject to comparable skills and experience. Future progression is based ...

We have an opening in our #DataScience core @icr.ac.uk.

The post will work on a breadth of topics across #cancer biology, but expertise in spatial data, single cell and data integration are priorities.

Details here: jobs.icr.ac.uk/vacancies/11...

@jobrxiv.bsky.social

Massive congratulations to Dr Natalie Fisher working within @incise-research.bsky.social with @joedwardswwcrc.bsky.social across @qubelfastofficial.bsky.social @cruk-si.bsky.social on being awarded an AACR-Woman in Cancer Research Scholar Award and selected for a talk at AACR conference

Super proud to have led this application with Dr Conchita Vens and showcase the amazing work done by @chrishalsey.bsky.social @mitosrus.bsky.social @scs-voice.bsky.social @cruk-si.bsky.social David Bryant and many many more over the last deacde

We are incredibly proud to announce that the School of Cancer Sciences has been awarded the prestigious Athena Swan Gold Award ⭐

If you are working on cellular plasticity, don't miss out on this rare FASEB conference opportunity in May with fantastic speaker lineup!
Abstract submission deadline: 3rd March
We still have slots for selected short talks! Early bird registration below 👇

events.faseb.org/event/Cellul...