Obi Griffith, PhD

MEN1 mutations mediate clinical resistance to menin inhibition - Nature Somatic mutations in MEN1 are identified in patients with leukaemia treated with a novel chromatin-targeting therapy, and the mechanism by which these mutations mediate therapeutic resistance&nbs...

A nice paper that acts as a great exemplar for curation of clinical variant information in CIViC (civicdb.org). www.nature.com/articles/s41.... The authors report on a clinical trial (evaluating the menin inhibitor revumenib in acute leukemia).

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This is what currently appears for PAR-24-039 - "Exploratory Grant Award to Promote Workforce Diversity in Basic Cancer Research (R21)". Applicants are being told they will not be reviewed any further, the NOFO is not active, and new applications are not being accepted grants.nih.gov/grants/guide...