bioRxiv Physiology

Cell-Specific Transcriptomic and Mito-Nuclear Imbalance in Lungs Under Intermittent Hypoxia in Adult Male Mice. https://www.biorxiv.org/content/10.1101/2025.08.05.668735v1

Mechanosensitive channel PIEZO1 enhances endometrial decidualization via BECN1-dependent autophagy https://www.biorxiv.org/content/10.1101/2025.08.05.668790v1

Polycystin-2 is cardioprotective against myocardial infarction by regulating the calcium-mediated ER stress response. https://www.biorxiv.org/content/10.1101/2025.08.05.668747v1

UCP1 Mitigates Hepatic Steatosis and Fibrosis Independent of Cold Exposure https://www.biorxiv.org/content/10.1101/2025.08.05.666925v1

Pediatric CHOP Chemotherapy Acutely Disrupts Satellite-Cell Dynamics and Blunts Muscle Mass in a Sex-Specific Manner https://www.biorxiv.org/content/10.1101/2025.08.04.668538v1

Exoproteome of calorie-restricted humans identifies complement deactivation as an immunometabolic checkpoint reducing inflammaging https://www.biorxiv.org/content/10.1101/2025.08.04.668533v1

Metabolic state shapes cortisol reactivity to acute stress: A systematic review and meta-analysis of metabolic and hormonal modulators https://www.biorxiv.org/content/10.1101/2025.08.05.668684v1

Gender gap between elite runners continues to shrink in the 21st century https://www.biorxiv.org/content/10.1101/2025.08.01.668047v1

A Frequency-Domain Framework for Cardiovascular Power Distribution https://www.biorxiv.org/content/10.1101/2025.07.31.667902v1

Chronic activation of a key exercise signal transducer, CaMKII, drives skeletal muscle aging and sarcopenia https://www.biorxiv.org/content/10.1101/2025.07.30.667744v1

Adaptive thermogenesis reprograms the behavioural and metabolic responses to protein restriction for successful amino acid homeostasis https://www.biorxiv.org/content/10.1101/2025.07.30.667623v1

Alpha Protein Kinase 3 Gene Therapy Restores Heart Function in Mouse and Human Models of Cardiomyopathy https://www.biorxiv.org/content/10.1101/2025.07.31.667858v1

MATERNAL OBESITY MODULATES FOXO1 ACTIVATION AND ADIPOGENESIS IN NEONATAL MESENCHYMAL STEM CELLS https://www.biorxiv.org/content/10.1101/2025.08.01.668117v1

Changes in DNA Methylation During Anoxia and Reoxygenation in Crucian Carp Brain https://www.biorxiv.org/content/10.1101/2025.07.30.667361v1

Thermogenic adipocytes alleviate hepatic steatosis and insulin resistance via macrophage cytokine secretion in obese mice https://www.biorxiv.org/content/10.1101/2025.08.01.667482v1

AAV6-HCN4t-mediated biological pacing as a potential life-saving therapy for congenital complete heart block https://www.biorxiv.org/content/10.1101/2025.07.31.666254v1

Isohydric species show earlier drought-induced declines in stem water content, rehydration, sap flow, and growth than anisohydric species https://www.biorxiv.org/content/10.1101/2025.07.30.666311v1

Formate reduces ischemic injury in female hearts lacking alcohol dehydrogenase 5 https://www.biorxiv.org/content/10.1101/2025.07.29.667470v1

Modern Times: Longitudinal Study of Toba/Qom Communities Reveals Delay and Shortening of Sleep in Real-Time Across Electrification https://www.biorxiv.org/content/10.1101/2025.07.28.667301v1

GSNOR deletion differentially alters age-related cardiac function in a sex-dependent manner. https://www.biorxiv.org/content/10.1101/2025.07.28.667309v1

Recent lifestyle change impacts sleep and circadian rhythms among the Indigenous peoples of Peninsular Malaysia https://www.biorxiv.org/content/10.1101/2025.07.26.666903v1

Understanding the Causal Impact of Elevated Maternal Stress During Pregnancy: A Systematic Literature Review of Guinea Pig Models https://www.biorxiv.org/content/10.1101/2025.07.30.667555v1

The Effect of Resistance Training Volume on Individual-Level Skeletal Muscle Adaptations: A Novel Replicated Within-Participant Unilateral Trial https://www.biorxiv.org/content/10.1101/2025.07.24.666533v1

From cells to organism - how natural selection causes metabolic scaling https://www.biorxiv.org/content/10.1101/2025.07.24.666547v1

Nuclear ASC speck formation in microglia is associated with inflammasome priming and is exacerbated in LRRK2-G2019S Parkinson disease https://www.biorxiv.org/content/10.1101/2025.07.25.666809v1

Chronic semaglutide treatment reveals stage-dependent changes to feeding behavior and metabolic adaptations in male mice https://www.biorxiv.org/content/10.1101/2025.07.24.666640v1

Rlim coordinates diurnal regulation of food intake and thermogenesis https://www.biorxiv.org/content/10.1101/2025.07.23.666379v1

APOE4 genotype negates the benefits of 17β-estradiol on cerebrovascular endothelial and mitochondrial function https://www.biorxiv.org/content/10.1101/2025.07.23.666474v1

Skeletal muscle mitochondrial responses to a single bout and six weeks of high load versus high volume resistance training in previously trained men https://www.biorxiv.org/content/10.1101/2025.07.23.666423v1

Voltage-sensor trapping of cardiac Na+ channels by Mg-protoporphyrin impairs cancer cell migration https://www.biorxiv.org/content/10.1101/2025.07.28.667138v1