@eur-thyroid-j.bsky.social
The international journal for basic, translational, and clinical #thyroidology. Fully #openaccess and the official journal of European Thyroid Association.
Multifocality and bilaterality in medullary thyroid cancer: basis for a proof-of-concept safety of lobectomy in European Thyroid Journal. By Virginia Cappagli et al.
Latest research by Virginia Cappagli et al. assesses the prevalence of multifocality in MTC & aims to provide proof of concept that lobectomy can be safely performed.
Their findings support the more conservative surgical option for certain patients with sporadic MTC.
๐ doi.org/10.1530/ETJ-25-0074
Prevalence of endogenous normal thyroid function 3 years after hemithyroidectomy for differentiated thyroid cancer in European Thyroid Journal. By Tina Toft Kristensen et al. Figure 2. (A, B, C, D) Diagrams demonstrating the prevalence of levothyroxine treatment according to the postoperative TSH goal 1 and 3 years after hemithyroidectomy for DTC. TSH, thyroid stimulating hormone; ATA, American Thyroid Association. Citation: European Thyroid Journal 14, 5; 10.1530/ETJ-24-0282
Hemithyroidectomy is chosen for low-risk DTC to preserve thyroid function, but the benefits in practice are lower than expected.
Tina Toft Kristensen et al. examine outcomes for patients managed under Danish guidelines, allowing TSH up to 4 mIU/L before LT4.
๐ doi.org/10.1530/ETJ-24-0282
Patient-derived medullary thyroid cancer organoids: a potential model for mechanistic studies on diagnostics and therapy in European Thyroid Journal. By Eline C Jager et al. Figure 1 In vitro self-renewal of organoid-forming cells from human putative medullary thyroid cancer stem cells. (A) Schematic of medullary thyroid cancer tissue isolation, primary tissue culture, and the self-renewal assay. (B) Primary MTC-thyrospheres 7 days in culture (p0) and MTOs at the end of p1, p2, and p3. Scale bars, 100 ฮผm. (C) Self-renewal potential of MTOs during passaging (n = 9 patients; error bars represent range). (D) In-medium secreted calcitonin and CEA levels from MTOs during passaging; calcitonin is plotted on the left y-axis, and CEA on the right y-axis (n = 3 patients; error bars represent SEM). European Thyroid Journal 14, 5; 10.1530/ETJ-24-0405
Trailblazing research by Eline C Jager et al. has successfully cultured organoids from medullary thyroid carcinoma biopsies, offering a novel in vitro model for physiological studies, drug discovery, tracer testing and drug screening.
๐Read the full research #OpenAccess: doi.org/10.1530/ETJ-...
๐Paediatric thyroid cancer is rising, calling for advances in clinical practice.
This timely collection will explore the new WHO classification, Bethesda system alongside the challenges in evaluation & treatment.
Contribute today: etj@bioscientifica.com
๐ bit.ly/4gjkdMQ
European Thyroid Journal. The evolving therapeutic landscape of Graves' disease in adults: present and future. By Marius N Stan and Chrysoula Dosiou. Journal Cover.
Therapeutics in Gravesโ disease are rapidly evolving ๐
Marius N. Stan @mayoclinic.org & Chrysoula Dosiou @stanford.edu explore how practices have shifted over time & the direction of future patient care.
๐ Read the full review: doi.org/10.1530/ETJ-25-0078
#GravesDisease #OpenAccess
European Thyroid Journal. Novel Insights in Advanced Thyroid Carcinoma Special Collection. New Review: Development of 3D organoid models to study aggressive thyroid cancers. By Eduardo Rios-Morris et al.
Organoid technology at the forefront of thyroid cancer research.
New review by Eduardo Rios-Morris et al. @iribhm.bsky.social explores how patient- and stem-cell-derived models are transforming our understanding of complex molecular mechanisms & personalised medicine.
doi.org/10.1530/ETJ-24-0392
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We've put together what I think is going to be a very good series of review articles on advanced thyroid cancer ๐
Mark this thread, I'll be posting articles as soon as they are released ๐
Published at the European Thyroid Journal ๐ฆ #OpenAccess
etj.bioscientifica.com/page/advance...
Validation of established thyroid ultrasound volume norms in a Chernobyl cohort in European Thyroid Journal. By Lydia B Zablotska et al. Figure 2 Total thyroid volume reference curves with common percentiles (P) for thyroid volume (mL) according to age (years), separately for males and females. Citation: European Thyroid Journal 14, 4; 10.1530/ETJ-25-0085
๐Research by Lydia B Zablotska et al. defines thyroid ultrasound volume norms for an iodine-deficient population exposed to environmental radiation.
The studied Chernobyl cohort demonstrated substantial differences from MOH norms and WHO standards.
Open Access: doi.org/10.1530/ETJ-25-0085
Become a reviewer. Complete 3 quality reviews in 1 calendar year and receive 25% off the full APC. Reviewer reward T&Cs apply.
Do you want to help shape the field of #thyroidology?
Join the European Thyroid Journal as a reviewer!
โ
Complete 3 quality reviews in 12 months
๐Get 25% off the APC on your next article
๐Find out more: etj.bioscientifica.com/page/charges...
๐จAny queries, please reach out: etj@bioscientifica.com
European Thyroid Journal logo. Pictured: Figure 1. Expert consensus testing algorithm for (A) differentiated thyroid cancer (DTC), (B) medullary thyroid cancer (MTC), and (C) anaplastic thyroid cancer (ATC). *If next-generation sequencing (NGS) testing and referral are not feasible, single-gene analysis of druggable genetic alterations is recommended; **Examples of high-risk clinical or pathologic features: high calcitonin levels both before and after surgery, short calcitonin doubling time, early distant metastases, histologically high-grade disease, tumor burden, and disease stage. IHC, immunohistochemistry; LENVAT/PEM, lenvatinib plus pembrolizumab; MDT, multidisciplinary teams; MKI, multikinase inhibitor; PCR, polymerase chain reaction; RAI, radioactive iodine; SoC, standard of care. Boxes in light red outline an algorithm path that involves testing and treatment with driver mutations. Boxes in light blue indicate steps in the algorithm that do not require testing. Citation: European Thyroid Journal 14, 4; 10.1530/ETJ-25-0024
โจCheck out the newly published expert opinion article by Aleลก Ryลกka et al. which outlines consensus testing algorithms for differentiated, medullary and anaplastic thyroid cancer to provide standardised recommendations for treating patients with advanced #ThyroidCancer.
๐ doi.org/10.1530/ETJ-...
European Thyroid Journal logo and image of ETJ journal. Text reads: Potential of bone marrow mesenchymal stem cells in iodine-induced autoimmune thyroiditis therapy. By Xun Liu et al.
Could mesenchymal stem cells offer a new opportunity to improve autoimmune thyroiditis?
Xun Liu et al. investigate the potential of MSCs in Hashimotoโs thyroiditis treatments.
๐Read the full article to learn more: doi.org/10.1530/ETJ-...
#Thyroid #Hashimotos
European Thyroid Journal logo with picture of front of journal, open-access logo and European Thyroid Association logo. Text reads: An open-access journal, publishing papers reporting original research in basic, translational and clinical thyroidology.
๐Thrilled to join the @bsky.app community!
We're here to share the latest research, updates and discussion on all aspects of basic, translational and clinical thyroidology.
Follow us for article highlights, themed collections and developments in the field.
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