Annina Schmid

We are beyond excited about this new MSc in Pain Neurosciences programme!! 🧑‍🎓👩‍🎓 come join our buzzing Oxford pain community!!

YouTube video by Modern Pain Podcast Whiplash Isn’t Just Neck Pain: What Clinicians Are Missing

Thanks for having us Mark, always nice to share science! Have a look at this if you are interested in whiplash associated disorder and our recent evidence for nerve pathology and neuropathic pain in some: youtu.be/yip3I689cwU

Thanks Ted, I will forward this to my collaborators🥳

Cool that these are helpful to you, I will watch out for your publications then!!

Illness perceptions and outcomes in people living with gout

We have an opportunity for a funded PhD studentship on 'Illness perceptions and outcomes in people living with gout'. See: www.keele.ac.uk/study/postgr... #KeeleMSK

and most importantly, a massive thank you to all participants who made this study possible. thank you for your generous time commitment and patience!

@ndcnoxford.bsky.social
@ox.ac.uk

A massive thank you again to all co-authors, particularly
Joel Fundaun, Colette Ridehalgh and Andrew Dilley.
Particular thanks to our generous funders
@versusarthritis.bsky.social @medresfdn.bsky.social

Overall, our results present a complex phenotypic profile for people with WADII and provide evidence suggestive of peripheral neuroinflammation in a subgroup of individuals.

Several serum pro-inflammatory cytokines were raised in people with WADII. So inflammation can be detected systemically. x.com/AnninaBSchmi...

Magnetic resonance imaging T2 signal ratio was increased in the C5 root of the brachial plexus and the C5-C8 dorsal root ganglia in WADII participants compared with healthy controls. We did not find changes in the distal median nerve trunk.

Evidence for peripheral neuroinflammation after acute... : PAIN a subgroup with underlying nerve involvement in WADII, such as peripheral neuroinflammation. This study aimed to investigate the presence of neuroinflammation in acute WADII using T2-weighted magnetic...

In the other publication published in
@painthejournal.bsky.social, we focussed on the presence of neuroinflammation in these patients using MRI, serum cytokine evaluation as well as other measures.
journals.lww.com/pain/fulltex...

Multivariable linear regression suggested low-cost bedside tests for hypoaesthesia at the index finger were prognostic for whiplash-related upper quadrant pain 6-months post-injury, however this association was weak.

We also took skin biopsies. Intraepidermal nerve fibre densities at the index finger were not significantly different between groups. However, dermal myelinated nerve bundles at the index finger were reduced 6-months post-injury in participants with WADII compared to controls.

Intriguingly, these functional changes were accompanied by elevated serum neurofilament light chain levels (a marker for axonal damage) acutely after whiplash. This normalised 6 months later. This suggests there is actual structural damage to axons in some people with WADII.

QST demonstrated significantly reduced thermal and mechanical detection thresholds in acute WADII compared to controls, some of which persisted at 6 months.

Within 4 weeks of injury, 65% of people with WADII had neuropathic pain which persisted in 32% 6-months post-injury.

In this @brain1878.bsky.social publication, we demonstrate that people with WADII (traditionally not considered to involve nerve injury) have signs of functional and structural nerve pathology.
academic.oup.com/brain/advanc...

What an exciting week: two papers published in
@brain1878.bsky.social and @painthejournal.bsky.social on the findings from our whiplash cohort. Massive thank you Joel Fundaun, Colette Ridehalgh, Andrew Dilley and other co-authors who were instrumental in making this happen. Short summary below.

a man in a suit and tie is holding a pen and hammer . ALT: a man in a suit and tie is holding a pen and hammer .

Do you have a basic science background and are interested in doing a PhD at Oxford University? Fully funded UK studentship available for 2025 intake to study the role of B-cells in human neuropathic pain

To apply please see here:
www.ndcn.ox.ac.uk/study-with-u...

Haha, welcome online Falko! Great to meet you!!!

Agree, super cool!!!

Thank you!!!

Wonderful, thank you!!! Still finding my way here 😉