Stephan Hacker's Avatar

Stephan Hacker

@stephanhacker2.bsky.social

Assistant Professor at Leiden University. Covalent inhibitors and chemoproteomics for antibiotics. Views my own. he/him/his. https://orcid.org/0000-0001-5420-4824

2,977 Followers  |  3,004 Following  |  1,324 Posts  |  Joined: 09.09.2023  |  2.0974

Latest posts by stephanhacker2.bsky.social on Bluesky

Are you interested in joining a local network of Assistant Professors at Leiden University and Leiden University Medical Centre? Join the kick-off meeting of APNet Leiden on 19.2.!

fd24.formdesk.com/universiteit...

#AssistantProfessor #Netherlands #Networking #Lobby

CC: @unileiden.bsky.social

04.02.2026 06:36 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Post image

APnet Leiden is having its kick-off meeting on February 19th to set up a local representation of #AssistantProfessors in Leiden.

If you are an Assistant professor at @unileiden.bsky.social or LUMC, consider joining this meeting to build a string network.

Sign up: fd24.formdesk.com/universiteit...

04.02.2026 06:32 โ€” ๐Ÿ‘ 2    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 1

I am very happy that we again managed to invite two world-leading scientists as keynotes for the 6th Virtual @chembiotalks.bsky.social.

We are working on an exciting additional program. Stay tuned!

Mailing list: fd24.formdesk.com/universiteit...

#ChemSky #ChemBio #ChemBioTalks

03.02.2026 15:20 โ€” ๐Ÿ‘ 12    ๐Ÿ” 2    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Join us at @apnet.bsky.social to amplify the voice of #AssistantProfessors in the #Netherlands.

03.02.2026 13:38 โ€” ๐Ÿ‘ 3    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Very much looking forward to the @led3hub.bsky.social Lecture by Christina Woo (@thewoolab.bsky.social)! I am sure it will be a great one.

If you are interested in #ChemicalProteomics and/or targeted protein degradation #TPD, you will not want to miss it.

#ChemSky #ChemBio #DrugDiscovery #degrader

02.02.2026 18:14 โ€” ๐Ÿ‘ 5    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Post image

We are looking forward to the LED3 Lecture of Christina Woo (@thewoolab.bsky.social) on February 26th. She will talk about "Rewriting Protein Modifications".

If you are interested, make sure to come by!

www.universiteitleiden.nl/en/science/l...

#ChemBio #ChemSky #ChemicalProteomics #TPD

02.02.2026 18:13 โ€” ๐Ÿ‘ 4    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 1
Post image

@anneosbourn.bsky.social (from @johninnescentre.bsky.social) is todayโ€™s @led3hub.bsky.social seminar speaker on Harnessing plant metabolic diversity for food and health applications
#NaturalProducts

29.01.2026 15:06 โ€” ๐Ÿ‘ 10    ๐Ÿ” 4    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Post image Post image

Great @led3hub.bsky.social Lecture by @anneosbourn.bsky.social. She talked about the amazing diversity of plant natural products, the gene clusters for their synthesis and their recombinant production for applications in #food and #health.

www.nature.com/articles/s41...
#Plants #NaturalProducts

29.01.2026 15:37 โ€” ๐Ÿ‘ 5    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Post image

We are very happy that @anneosbourn.bsky.social from the @johninnescentre.bsky.social visited us today for a LED3 Lecture. She talked about "Harnessing plant metabolic diversity for food and health applications".

#Plants #NaturalProducts #GeneClusters #DrugDiscovery #ChemBio #ChemSky #Food #Health

29.01.2026 15:27 โ€” ๐Ÿ‘ 3    ๐Ÿ” 3    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

I think the latter might indeed be a valuable option. I think the former has some risks as some people e.g. stay Assistant Professor for their entire career, but then do not qualify as ECRs. Also, personally I see the risk that some people may be delayed in promotion to keep them eligible.

27.01.2026 06:50 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0
Post image

Are you interested in cutting edge #Biochemistry and #ChemBio?

Check out our #Biochemistry2026 meeting in Wรผrzburg from March 16th to 18th.

Deadlines for reduced early bird registration fee and abstracts have been extended to January 28th.

veranstaltungen.gdch.de/microsite/in...

26.01.2026 20:18 โ€” ๐Ÿ‘ 4    ๐Ÿ” 3    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 1
KNAW Early Career Partnerships - KNAW Researchers at the beginning of their careers can apply for up to EUR 10,000 to organise an interdisciplinary meeting in the Academy's Trippenhuis complex or another location of their choice.

Interested in setting up a meeting to expand your interdisciplinary network?

The @knaw-nl.bsky.social may have the right funding for you:
- you have defended your PhD 3 to 7 years ago
- you work in academia in the Netherlands
- up to 10,000 โ‚ฌ
- deadline is February 2nd

www.knaw.nl/en/funds-and...

26.01.2026 20:14 โ€” ๐Ÿ‘ 2    ๐Ÿ” 1    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

Any tips how to best approach them?

10.01.2026 08:57 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Ah OK. Thanks so much for the information. Recently a lot of paper posts have been there and gotten good traction.

10.01.2026 07:27 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

Thank you for tracking @bsky.app activity. Any plans to track also mentions on linkedin in the future?

10.01.2026 04:37 โ€” ๐Ÿ‘ 2    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

We have an exciting remaining program for our @led3hub.bsky.social Lectures of this academic year. Make sure to mark your calendars and come by.

CC: @leidenscience.bsky.social

08.01.2026 10:50 โ€” ๐Ÿ‘ 3    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Post image

We are looking forward to the LED3 Lecture of Anne Osbourn on January 29th She will talk about "Harnessing plant metabolic diversity for food and health applications".

If you are interested, make sure to come by!

www.universiteitleiden.nl/en/science/l...

#ChemBio #ChemSky #Plants #Metabolites

07.01.2026 14:45 โ€” ๐Ÿ‘ 2    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Post image

If you are a #PhD candidate and want to attend #Biochemistry2026 (veranstaltungen.gdch...), make sure to apply for our meeting award, which comes with 500 โ‚ฌ for the attendance and a free year of membership in @gdchbiochem.bsky.social
en.gdch.de/network-s...

07.01.2026 12:00 โ€” ๐Ÿ‘ 3    ๐Ÿ” 3    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

We have a great line-up of speakers including:
Jennifer Andexer, Helge Bode, Stephan Hammer, Akane Kawamura, Alexandria (Ali) Deliz Liang, Carina de Oliveira Mann, Stefan Raunser, Schraga Schwartz, Pierre Stallforth, Carine Tisnรฉ, Satpal Virdee, Wilfred van der Donk
#Chemistry #Meeting
CC: @gdch.de

06.01.2026 11:00 โ€” ๐Ÿ‘ 2    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Post image

๐Ÿ“ข Deadline Extended to January 15th, 2026!

Apply for our Meeting Award to get:

โœ… 500 โ‚ฌ grant for the #Biochemistry2026 conference
โœ… 1 year of free Fachgruppe Biochemie membership

Apply now: en.gdch.de/network-s...

Share with a #ECR who needs to see this!

#Chemistry #ChemBio #PhD @gdch.de

06.01.2026 12:00 โ€” ๐Ÿ‘ 3    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Post image

Are you interested in cutting-edge #Biochemistry and #ChemBio? Join us for the GDCh #Biochemistry2026 conference in Wรผrzburg on March 16th to 18th, 2026.

Registration is now open and you can submit an abstract until January 10th, 2026: veranstaltungen.gdch...
(1/2)

06.01.2026 11:00 โ€” ๐Ÿ‘ 5    ๐Ÿ” 1    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 1

Registration is open for the GDCh #Biochemistry conference๐Ÿ‘‡

06.01.2026 11:39 โ€” ๐Ÿ‘ 3    ๐Ÿ” 2    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Post image

Great speech by the new president of @unileiden.bsky.social, Luc Sels, at the New Year's reception of @leidenscience.bsky.social. He gave great insights into his vision for the future of our university including excellent fundamental science, collaboration, internationalization and societal impact.

06.01.2026 15:35 โ€” ๐Ÿ‘ 3    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Post image

Very interesting Tuesday Talk by Meindert Lamers at the New Year's reception of @leidenscience.bsky.social. He talked about the power of different electron microscopy techniques to visualize biological samples on length scales from tissues to individual molecules. www.nature.com/articles/s44...

06.01.2026 15:14 โ€” ๐Ÿ‘ 4    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Post image

Our dean Jasper Knoester addresses our faculty @leidenscience.bsky.social in his New Year's speech. Interesting insights into the future strategic goals of our faculty and great to hear him highlight the priority themes including the @led3hub.bsky.social with new theme leader @mvdstelt.bsky.social.

06.01.2026 14:48 โ€” ๐Ÿ‘ 4    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Proof that you can never keep up with the literature ๐Ÿค•

Great list @stephanhacker2.bsky.social and thanks for sharing.

05.01.2026 16:26 โ€” ๐Ÿ‘ 1    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

wow! Thanks for the shoutout ๐Ÿฅน Hopefully our papers in the coming year will continue to impress ๐Ÿ˜‰

stay tuned!!

04.01.2026 06:54 โ€” ๐Ÿ‘ 8    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Overall, I hope that 2026 will yield at least the same degree of scientific progress as 2025. (12/12)

#Chemistry #ChemBio #Science #Antibiotics #Synthesis #TPD #Degrader #Proteomics #Kinases #RNA #Screening #CovalentInhibitors #DirectToBiology

04.01.2026 06:43 โ€” ๐Ÿ‘ 3    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0
Preview
Experimental glycopeptide antibiotic EVG7 prevents recurrent Clostridioides difficile infection by sparing members of the Lachnospiraceae family - Nature Communications Treatment of Clostridioides difficile infections (CDI) with vancomycin is associated with high relapse rates. In this study, the experimental glycopeptide antibiotic EVG7 was found to effectively trea...

The groups of Nathaniel Martin of our @led3hub.bsky.social and the @smitslab.bsky.social published the powerful semisynthetic guanidino lipoglycopeptide EVG7 to treat Clostridioides difficile infections. (11/12)
www.nature.com/articles/s41...

04.01.2026 06:43 โ€” ๐Ÿ‘ 4    ๐Ÿ” 2    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0
Preview
Spiro-C(sp3)-atom transfer: Creating rigid three-dimensional structures with Ph2SCN2 The introduction of a single C-atom into organic substrates typically results in the formation of flat molecules containing unsaturated C(sp)-centers. Adding a single C(sp3)-atom surrounded by four ฯƒ-...

The Max Hansmann group published that Ph2SCN2 introduces a single sp3 carbon atom into molecules to form up to 4 Cโ€“C ฯƒ-bonds in one step without using transition metal catalysis giving exciting, highly 3-dimensional structures. (10/12)
www.science.org/doi/10.1126/...

04.01.2026 06:43 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

@stephanhacker2 is following 20 prominent accounts