Fluicell

Two researchers using a Biopixlar bioprinting system. Both researchers are looking at a computer monitor showing a microscopic view of cells being dispensed on a surface, while one of them uses a gamepad to control the instrument.

We installed a Biopixlar bioprinting system at @crick.ac.uk this week. Big thanks to amazing team at Making Lab for the smooth setup and warm welcome. Getting to see your facilities firsthand and hear about your research has been truly inspiring.

🧫 Read more about how Fluicell's microfluidic single-cell bioprinitng technology Biopixlar plays creates new opportunities for building high-fidelity models of early cancer development.
🔗 www.fluicell.com/news/a-bioen...

How can tissue engineering and biofabrication technologies advance cancer research? In a new review, Bertassoni and coworker explore how early cancer models facilitate a transition from treating to intercepting disease.

Rational antibody design for undruggable targets using kinetically controlled biomolecular probes This newly developed biological probes/proteomics method yields functional antibodies targeting previously undruggable targets.

In recognition of the breast cancer awareness month, we are highlighting research that pave the way for new breast cancer treatments. Here, Trkulja et al present a method for designing antibodies for undruggable targets such as KRAS, whihch is implicated in TNBC.
www.science.org/doi/10.1126/...

“Some of my proudest moments as a researcher have been when I have been able to solve problems by going back to my notes to figure out the cause.”

👋 Meet Anton Rydberg and find out how applying a scientific mindset has value in both research and training.

🔗 www.fluicell.com/people/anton...

Protocol for single-cell spatial transcriptomic profiling of cultured cells and engineered tissues without embedding or sectioning Spatial transcriptomics is a powerful tool for investigating how cellular composition and spatial relationships influence cell behavior. Here, we pres…

🧪 Want to combine bioprinitng and single-cell spatial transcriptomics? In a new paper in STAR Protocols, researchers at @ohsuknight.bsky.social present at method for spatial transcriptomics adapted for in vitro systems in 2D.

🔗 www.sciencedirect.com/science/arti...

🔬 Last week we had the great pleasure of opening a new part of our lab at Fluicell focused on extended tissue and cell culture studies. This new space further enhances our ability to analyze tissue development, cell function and cell survivability over time.

🔬 Last week we had the great pleasure of opening a new part of our lab at Fluicell focused on extended tissue and cell culture studies. This new space further enhances our ability to analyze tissue development, cell function and cell survivability over time.

👋Join us in welcoming Rosa Lacordaire and Charlotte Cany from @espciparispsl.bsky.social who are doing a research internship with us.

Supporting young researchers is an important part of Fluicell’s commitment to building the future of life science, and we’re excited to follow their progress.

We are excited to announce that we are partnering with Ambusol to create groundbreaking new ways to treat cancer. Leveraging our microfluidic technology, we are developing a novel type of device for high precision drug delivery directly to the tumor.

🔗 www.fluicell.com/news/fluicel...

A parent kissing a child. The child is looking slightly upwards and smiles. Text below the picture reads "Fluicell receives Breakthrough T1D project funding".

🚀 We are excited to announce that we have received funding from Breakthrough T1D for a collaboration to develop type 1 diabetes tissue therapeutics.

The collaboration combines our Nexocyte platfom with unique stem cell material to build designer islets for type 1 diabetes treatment.

Read more about the collaboration on Fluicell's website: www.fluicell.com/news/fluicel...

#Diabetes #CellTherapy #ATMP #Biofabrication

A parent kissing a child. The child is looking slightly upwards and smiles. Text below the picture reads "Fluicell receives Breakthrough T1D project funding".

🚀 We are excited to announce that we have received funding from Breakthrough T1D for a collaboration to develop type 1 diabetes tissue therapeutics.

The collaboration combines our Nexocyte platfom with unique stem cell material to build designer islets for type 1 diabetes treatment.

🧪 Researchers at @uofcalifornia.bsky.social have discovered new ways to selectively target specific voltage-gated sodium channels, affecting neuronal excitability. Their results can enable more precise ways to treat epilepsy and other neurological conditions.

🔗 www.fluicell.com/news/selecti...

🧪 Researchers at @uofcalifornia.bsky.social have discovered new ways to selectively target specific voltage-gated sodium channels, affecting neuronal excitability. Their results can enable more precise ways to treat epilepsy and other neurological conditions.

🔗 www.fluicell.com/news/selecti...

🧪Are you attending #AACR25? Make sure to check out the poster "Bioprinting 3D spatially resolved tumor avatars to mimic the native tumor microenvironment" presented by Haylie Helms of @ohsuknight.bsky.social (abstract nr LB161).

🔗 aacrjournals.org/cancerres/ar...
#CancerResearch #Bioprinting

A stunning example of biological complexity and the important relationship between tissue microstructure and function

BIRDIE Project Website Visit the post for more.

🔗 Check out the BIRDIE website to learn more about the project: birdieproject.eu

YouTube video by Fluicell AB BIRDIE From bench to business workshop

Last week, the BIRDIE project organized a workshop to discuss how to bring in vitro research models from bench to business.

You can now watch a recorded version of the workshop, giving you the chance to learn more about organ-on-chip standardization, bioethics and in vitro model commercialization

🔗Read more about our Nexocyte platforom on our website: www.fluicell.com/platform

#Bioprinting #TissueEngingeering #RegenerativeMedicine

Microscope image of a bioprinted organoid. The image is partly covered by a white donut shape. Black text against a yellow background reads "Fluicell tissue technology patent granted in the EU".

We are excited to announce that our technology for generating three dimensional biological tissues has been granted a patent in the EU. The technology is the foundation for our tissue-based products for regenerative medicine and drug development targeting type 1-diabetes and cardiac disease.

Image of MDCK cell labeled using the light-activated photo-click adapters provided by Dr. Sarah Innes-Gold of Harvard University.

Microscope image showing cell fluorescently labeled in a crosshatch pattern. Text in the image reads "Publication spotlight: Tools for intersectional optical and chemical tagging on cell surfaces"

Can light be a tool for labeling living cells? In a new study from researchers at @harvard.edu and Chinese Academy of Medical Sciences, Sarah Innes-Gold et al. present a method for light-activated cell labeling with high precision. Read more on our website.

🔗 www.fluicell.com/news/scienti...

A Biohybrid Dynamic Random Access Memory We report that GABAA receptors in a patch-clamped biological cell form a short-term memory circuit when integrated with a scanning-probe microfluidic device. Laminar patterns of receptor activators (a...

Owe Orwar and team have created a biohybrid random access memory based on patch-clamped GABA receptors placed in an open volume microfluidic device, generating laminar agonist patterns. The receptors read and store the chemical input signals as state distribution.
#JournalClub #Biohybrid #Dynaflow

Kinetic Analysis of the Early Signaling Steps of the Human Chemokine Receptor CXCR4 G protein–coupled receptors (GPCRs) are biologic switches that transduce extracellular stimuli into intracellular responses in the cell. Temporally resolving GPCR transduction pathways is key to under...

Resolving GPCR-kinetics is key for understanding how external stimuli is converted to cellular response.

Using FRET, Carsten Hoffmann and team study how CXC chemokine receptor 4 ligands affect activation, revealing distinct mechanisms that reflect pharmacological properties.
#JournalClub

Kinetic Analysis of the Early Signaling Steps of the Human Chemokine Receptor CXCR4 G protein–coupled receptors (GPCRs) are biologic switches that transduce extracellular stimuli into intracellular responses in the cell. Temporally resolving GPCR transduction pathways is key to under...

Resolving GPCR-kinetics is key for understanding how external stimuli is converted to cellular response.

Using FRET, Carsten Hoffmann and team study how CXC chemokine receptor 4 ligands affect activation, revealing distinct mechanisms that reflect pharmacological properties.
#JournalClub

Platform

At Fluicell, we have removed the need for bioinks altogether by building tissues directly in solution using open volume microfluidics. This lets us place cells close together with single-cell precision, enabling efficient intercellular communication.

Discover more on our website 👇

Great to see the diversity of approaches when it comes to addressing biofabrication challenges such as tissue resolution, scalability and functional control!

We need a breadth of new technologies to fully realize the potential of biofabrication within therapeutics and drug development.

Nothing in life is to be feared, it is only to be understood. Marie Curie, Physicist and chemist.

Today is International Day of Women & Girls in Science.

Marie Curie, the first woman to win a Nobel Prize. Her contributions have left an indelible mark on the world of science & health & continue to inspire generations of scientists & innovators. 🔬 #WomenInScience #WomenInSTEM

Structure- and Ligand-Based Discovery of Chromane Arylsulfonamide Nav1.7 Inhibitors for the Treatment of Chronic Pain Using structure- and ligand-based design principles, a novel series of piperidyl chromane arylsulfonamide Nav1.7 inhibitors was discovered. Early optimization focused on improvement of potency through...

McKerrall has used structure- and ligand-based design principles to discover a new series of Nav 1.7 inhibitors. Through compound optimization, the researchers were able to select a highly potent and metabolically stable, subtype selective Nav1.7 inhibitor for further studies in vivo

#JournalClub