Miguel Godinho Ferreira

📢 Hiring 2 Postdocs (CNRS Research Engineer) @ IRCAN (Université Côte d’Azur), Nice 🇫🇷. Spread the word, please.

Focus: intestine aging & immunity in fish 🐟
Start Nov–Dec 2025 • ~€3,175/mo

Apply:
ImmunoGUT (zebrafish) → tinyurl.com/3jx9a4ks
GUTPOWER (reef fish) → tinyurl.com/mt2ekpks

Nucleic acid sensing and innate immunity - Academy 4 Seminar Series #19 - Le Galet CHU PASTEUR NICE - October 21st, 2025 - Université Côte d'Azur

Interested in cGAS-STING? Come and join us on 21st of October 2025 (9:30-12:30) in Nice, France!

univ-cotedazur.fr/recherche-in...

In London, hate will never win.

Envelhecimento: “Até agora, ninguém conseguiu rejuvenescer ninguém” O que são os telómeros? Como pode o peixe-zebra ajudar no estudo do envelhecimento? Miguel Godinho Ferreira, cientista português a trabalhar em França, responde. Falemos então sobre a longevidade.

Aging: “So far, no one has managed to rejuvenate anyone.” What are #telomeres? How can #zebrafish help in the study of #aging? Miguel Godinho Ferreira, a Portuguese scientist working in France, answers. Let's talk about longevity and aging.

(Portuguese only)
www.publico.pt/2025/09/16/c...

Great opportunity to meet with French zebrafish community! Our lab will gladly join! Go fish! 🐟

It is so nice to have this trail on our recent work. Thank you, @cyrilpedia.bsky.social! The follow up is just around the corner! 🙂

cGAS-STING are responsible for premature aging of telomerase-deficient zebrafish | The EMBO Journal imageimageTelomere erosion is a hallmark of aging, yet its downstream mechanisms and impact on organismal aging remain unclear. This study shows that cGAS-STING inflammatory signaling drives premature...

www.embopress.org/doi/full/10....

This cover highlights the article cGAS-STING are responsible for premature aging of telomerase-deficient zebrafish by Naz Şerifoğlu, Miguel Godinho Ferreira and colleagues. cGAS-STING are responsible for the premature aging of telomerase-deficient zebrafish. Short telomeres lead to genomic instability, inducing cGAS-STING pathway stimulation. cGAS-STING pathway inactiva-tion halts DNA damage response in the presence of short telomeres and rescues tissue proliferation, leading to overall recovery of organism fitness and survival. The front cover image shows the PCNA staining of intestinal tissues from Sting-deficient zebrafish. Scientific image by N. Şerifoğlu

Comment in issue 17: Making sense of oxygen sensing
Glutamine sensing by mTORC1 via GCN2
Androgen signaling control via Parp7 and an ADP-ribosyl degron
Dendrite-like pseudopods let macrophages ingest bacteria
Cover by @miguelgf.bsky.social et al
www.embopress.org/toc/14602075...

cGAS-STING are responsible for premature aging of telomerase-deficient zebrafish | The EMBO Journal imageimageTelomere erosion is a hallmark of aging, yet its downstream mechanisms and impact on organismal aging remain unclear. This study shows that cGAS-STING inflammatory signaling drives premature aging in response to telomere shortening in ...

Our paper was offered the cover of The EMBO Journal. 😀
We discovered that activation of cGAS-STING causes aging in response to very short telomeres. Zebrafish deficient in telomerase and sting, reverse premature death, reduced fertility, frailty and cancer.
👉 tinyurl.com/nhd4bfb9

The house mouse maintains constant telomere length throughout life Abstract. Telomeres protect the chromosome ends from deleterious DNA damage response and repair activities. In humans, telomerase maintains telomere length

Not all species age the same way 😉
“We conclude that M. musculus maintains long telomeres in blood and tail throughout life”
Congrats Rhian and Dudy et al! 👏

House mouse maintains constant telomere length throughout life
url: academic.oup.com/nar/article/...

What’s on at #GIMMFest Day 1 & 2? We’ll kick things off with big ideas to spark your curiosity, then dive into fresh perspectives on the future of aging and the everyday experiences that shape it.

🔗 gimm.pt/pt-pt/gimm-festival/#program

Proud to contribute to this (Yes!) #Telomere study by Farida Djouad team. Morpholinos against zebrafish #TRF2 induce macrophage #senescence and block fin regeneration. #Parabiosis, #MacrophageTracking & #Transcriptomics show #p16-high, and low pro-inflammation.
Go Fish! 🐟🐟🐟
www.thno.org/v15p7308.htm

Thank you, Kevin! Your work will be sorely missed... "So long and thanks for all the fish!" 🐟

Telomeric antisense oligonucleotides reduce premature aging phenotypes in telomerase mutant zebrafish - preLights Unlocking the Fountain of Youth: Inhibition of telomeric DNA damage response reduces premature aging in zebrafish

Unlocking the Fountain of Youth ⛲: Inhibition of telomeric DNA damage response reduces premature aging in #zebrafish

#preLight prepared by Jawdat Sandakly⬇️ 👀

prelights.biologists.com/highlights/t...

Highlights work from @miguelgf.bsky.social et al. 🐟

Thanks for the highlight, ‪@zebrafishrock.bsky.social‬! This is the first last author paper of Bruno Lopes-Bastos.
We are very happy for this!

Thanks for the highlight, ‪@zebrafishrock.bsky.social‬! This is the first last author manuscript of Bruno Lopes-Bastos.
We are very happy for this!

Join us in Lisbon for the GIMM Festival: #Aging and #Longevity, happening September 4–6! Explore the future of aging with 20+ invited international experts.
Secure your spot on: gimm.pt/gimm-festival/
@nataging.nature.com

Here’s the EMBO Journal highlight on our paper!

cGAS-STING are responsible for premature aging of telomerase-deficient zebrafish | The EMBO Journal imageimageTelomere erosion is a hallmark of aging, yet its downstream mechanisms and impact on organismal aging remain unclear. This study shows that cGAS-STING inflammatory signaling drives premature...

cGAS-STING are responsible for premature aging of telomerase-deficient zebrafish | The EMBO Journal www.embopress.org/doi/full/10....

cGAS-STING are responsible for premature aging of telomerase-deficient zebrafish | The EMBO Journal imageimageTelomere erosion is a hallmark of aging, yet its downstream mechanisms and impact on organismal aging remain unclear. This study shows that cGAS-STING inflammatory signaling drives premature aging in response to telomere shortening in ...

cGAS-STING are responsible for premature aging of telomerase-deficient zebrafish
www.embopress.org/doi/full/10....

It was a pleasure to invite our neighbour Corine BERTOLOTTO to IRCAN. It was a great review of the lab's work and a very nice return to Hopital Pasteur, Nice.

"Uveal melanomas: identification of new prognosis biomarkers and therapeutic targets"

A chart showing cancelled NIH grants

“I would like to cure brain cancer. I think that's not particularly controversial.” Be that as it may, the NIH terminated that scientist's grant. Here's a huge survey of the 2,500 grants that NIH has killed or delayed...so far. Gift link: nyti.ms/43Jz1yJ

TODAY - You are still on time for early bird registration for the GIMM Festival on #Aging and #Longevity!
Lisbon from 4–6 September 2025.

GIMM Fest | Aging and Longevity: Registrations open now! September 4-6 2025, Portugal, Lisbon. The brand new Gulbenkian Institute, launching – the very first GIMM Festival – "Aging and Longevity" to explore the future of aging through science. gimm.pt/gimm-festival/

Telomeric antisense oligonucleotides reduce premature aging phenotypes in telomerase mutant zebrafish Telomerase activity is restricted in somatic cells, resulting in progressive telomere shortening. Telomere erosion eventually activates the DNA damage response (DDR), inducing cell-cycle arrest and ce...

Our latest preprint!
We show that telomeric antisense oligonucleotides alleviate premature #aging in #telomerase mutant #zebrafish. A collaboration with the labs of Fabrizio d'Adda di Fagagna and Marina Mione.
Congrats Bruno for his first corresponding author paper!👏
www.biorxiv.org/content/10.1...

Europe can capture the US brain drain — if it acts fast Countries must cooperate to seize a once-in-a-generation opportunity to become the top destination for scientists.

"CERN (..) was created in the 1950s by physicists, who persuaded governments to invest in shared infrastructure and long-term collaboration. Now, it (...) thrives thanks to stable funding, open science and a culture of international partnership."
www.nature.com/articles/d41...

This is a fantastic symposium on the Biology of Aging organized by the GIMM in Lisbon next September 4-6, and with an opportunity for non-specialists to join the discussions. Stellar speaker lineup in beautiful Lisbon:
gimm.pt/gimm-festival/

Joao will be one of our discussion leaders!
Join us: Lisbon, 4–6 Sept 2025! 🇵🇹
👉 gimm.pt/gimm-festival/

Absolutely thrilled to join the @gimmfoundation.bsky.social GIMM Festival 2025 in Lisbon at the Pavilhão Portugal from 4-6 September 2025. What questions do we need to ask to build a unifying theory of aging? Join a great lineup of speakers to discuss concepts of the biology gimm.pt/gimm-festiva...