Miguel Godinho Ferreira

The age of animal experiments is waning. Where will science go next? Advances in organ and computer models are raising the prospect that some animal experiments could be eliminated. But there are still huge hurdles to overcome.

The "brave new world" of biomedical research: organs-on-chips, organoids and computational models. 🔬 🧪 🐁 🐟
A must read... 👇
www.nature.com/articles/d41...

But I am sure Sandro Cellerino would be happy to comment on their ethic concerns on their research.

It is definitely a concern that is considered by the researchers. These animals are caught (and eaten) by Islanders and, consequently, also studied. They endangered status will always be an central issue given their extremely late reproductive onset (estimated at 150yo).

The Greenland shark, the longest-lived vertebrate, does not avoid heart aging. Instead, it resists heart disease and maintains organ function into extreme old age. Preserving a "youthful state" is not the only path to longevity.
Preprint by Cellerino lab👇
www.biorxiv.org/content/10.6...

I am excited to begin a #Sabbatical at @ki.se (Genander Lab).
We are expanding our #zebrafish findings (PMID: 37142828, 40490553) to human #organoids to study #cGAS-#STING #inflammation and #telomerase rescue in the #GI tract. 🧬🩺
Special thanks to @EMBO.org @cnrs.fr for the support. #Aging #TBDs

YouTube video by Leibniz-Institut für Alternsforschung - FLI e.V. Interview with Dr. Miguel Godinho Ferreira

Me answering 5 questions on #science and #aging during my recent visit to the @leibnizfli.bsky.social Institute in Jena, Germany. ☺️

youtu.be/nJZu0Su0lbs?...

Happy and proud with our lab’s presentations at Second @frenchzebrafish.bsky.social meeting in Toulouse!
Go Fish 🇫🇷🐟!

📢 Hiring 2 Postdocs (CNRS Research Engineer) @ IRCAN (Université Côte d’Azur), Nice 🇫🇷. Spread the word, please.

Focus: intestine aging & immunity in fish 🐟
Start Nov–Dec 2025 • ~€3,175/mo

Apply:
ImmunoGUT (zebrafish) → tinyurl.com/3jx9a4ks
GUTPOWER (reef fish) → tinyurl.com/mt2ekpks

📢 Hiring 2 Postdocs (CNRS Research Engineer) @ IRCAN (Université Côte d’Azur), Nice 🇫🇷. Spread the word, please.

Focus: intestine aging & immunity in fish 🐟
Start Nov–Dec 2025 • ~€3,175/mo

Apply:
ImmunoGUT (zebrafish) → tinyurl.com/3jx9a4ks
GUTPOWER (reef fish) → tinyurl.com/mt2ekpks

Nucleic acid sensing and innate immunity - Academy 4 Seminar Series #19 - Le Galet CHU PASTEUR NICE - October 21st, 2025 - Université Côte d'Azur

Interested in cGAS-STING? Come and join us on 21st of October 2025 (9:30-12:30) in Nice, France!

univ-cotedazur.fr/recherche-in...

In London, hate will never win.

Envelhecimento: “Até agora, ninguém conseguiu rejuvenescer ninguém” O que são os telómeros? Como pode o peixe-zebra ajudar no estudo do envelhecimento? Miguel Godinho Ferreira, cientista português a trabalhar em França, responde. Falemos então sobre a longevidade.

Aging: “So far, no one has managed to rejuvenate anyone.” What are #telomeres? How can #zebrafish help in the study of #aging? Miguel Godinho Ferreira, a Portuguese scientist working in France, answers. Let's talk about longevity and aging.

(Portuguese only)
www.publico.pt/2025/09/16/c...

Great opportunity to meet with French zebrafish community! Our lab will gladly join! Go fish! 🐟

It is so nice to have this trail on our recent work. Thank you, @cyrilpedia.bsky.social! The follow up is just around the corner! 🙂

cGAS-STING are responsible for premature aging of telomerase-deficient zebrafish | The EMBO Journal imageimageTelomere erosion is a hallmark of aging, yet its downstream mechanisms and impact on organismal aging remain unclear. This study shows that cGAS-STING inflammatory signaling drives premature...

www.embopress.org/doi/full/10....

This cover highlights the article cGAS-STING are responsible for premature aging of telomerase-deficient zebrafish by Naz Şerifoğlu, Miguel Godinho Ferreira and colleagues. cGAS-STING are responsible for the premature aging of telomerase-deficient zebrafish. Short telomeres lead to genomic instability, inducing cGAS-STING pathway stimulation. cGAS-STING pathway inactiva-tion halts DNA damage response in the presence of short telomeres and rescues tissue proliferation, leading to overall recovery of organism fitness and survival. The front cover image shows the PCNA staining of intestinal tissues from Sting-deficient zebrafish. Scientific image by N. Şerifoğlu

Comment in issue 17: Making sense of oxygen sensing
Glutamine sensing by mTORC1 via GCN2
Androgen signaling control via Parp7 and an ADP-ribosyl degron
Dendrite-like pseudopods let macrophages ingest bacteria
Cover by @miguelgf.bsky.social et al
www.embopress.org/toc/14602075...

cGAS-STING are responsible for premature aging of telomerase-deficient zebrafish | The EMBO Journal imageimageTelomere erosion is a hallmark of aging, yet its downstream mechanisms and impact on organismal aging remain unclear. This study shows that cGAS-STING inflammatory signaling drives premature aging in response to telomere shortening in ...

Our paper was offered the cover of The EMBO Journal. 😀
We discovered that activation of cGAS-STING causes aging in response to very short telomeres. Zebrafish deficient in telomerase and sting, reverse premature death, reduced fertility, frailty and cancer.
👉 tinyurl.com/nhd4bfb9

The house mouse maintains constant telomere length throughout life Abstract. Telomeres protect the chromosome ends from deleterious DNA damage response and repair activities. In humans, telomerase maintains telomere length

Not all species age the same way 😉
“We conclude that M. musculus maintains long telomeres in blood and tail throughout life”
Congrats Rhian and Dudy et al! 👏

House mouse maintains constant telomere length throughout life
url: academic.oup.com/nar/article/...

What’s on at #GIMMFest Day 1 & 2? We’ll kick things off with big ideas to spark your curiosity, then dive into fresh perspectives on the future of aging and the everyday experiences that shape it.

🔗 gimm.pt/pt-pt/gimm-festival/#program

Proud to contribute to this (Yes!) #Telomere study by Farida Djouad team. Morpholinos against zebrafish #TRF2 induce macrophage #senescence and block fin regeneration. #Parabiosis, #MacrophageTracking & #Transcriptomics show #p16-high, and low pro-inflammation.
Go Fish! 🐟🐟🐟
www.thno.org/v15p7308.htm

Thank you, Kevin! Your work will be sorely missed... "So long and thanks for all the fish!" 🐟

Telomeric antisense oligonucleotides reduce premature aging phenotypes in telomerase mutant zebrafish - preLights Unlocking the Fountain of Youth: Inhibition of telomeric DNA damage response reduces premature aging in zebrafish

Unlocking the Fountain of Youth ⛲: Inhibition of telomeric DNA damage response reduces premature aging in #zebrafish

#preLight prepared by Jawdat Sandakly⬇️ 👀

prelights.biologists.com/highlights/t...

Highlights work from @miguelgf.bsky.social et al. 🐟

Thanks for the highlight, ‪@zebrafishrock.bsky.social‬! This is the first last author paper of Bruno Lopes-Bastos.
We are very happy for this!

Thanks for the highlight, ‪@zebrafishrock.bsky.social‬! This is the first last author manuscript of Bruno Lopes-Bastos.
We are very happy for this!

Join us in Lisbon for the GIMM Festival: #Aging and #Longevity, happening September 4–6! Explore the future of aging with 20+ invited international experts.
Secure your spot on: gimm.pt/gimm-festival/
@nataging.nature.com

Here’s the EMBO Journal highlight on our paper!

cGAS-STING are responsible for premature aging of telomerase-deficient zebrafish | The EMBO Journal imageimageTelomere erosion is a hallmark of aging, yet its downstream mechanisms and impact on organismal aging remain unclear. This study shows that cGAS-STING inflammatory signaling drives premature...

cGAS-STING are responsible for premature aging of telomerase-deficient zebrafish | The EMBO Journal www.embopress.org/doi/full/10....

cGAS-STING are responsible for premature aging of telomerase-deficient zebrafish | The EMBO Journal imageimageTelomere erosion is a hallmark of aging, yet its downstream mechanisms and impact on organismal aging remain unclear. This study shows that cGAS-STING inflammatory signaling drives premature aging in response to telomere shortening in ...

cGAS-STING are responsible for premature aging of telomerase-deficient zebrafish
www.embopress.org/doi/full/10....

It was a pleasure to invite our neighbour Corine BERTOLOTTO to IRCAN. It was a great review of the lab's work and a very nice return to Hopital Pasteur, Nice.

"Uveal melanomas: identification of new prognosis biomarkers and therapeutic targets"