Miguel Godinho Ferreira

Proud to contribute to this (Yes!) #Telomere study by Farida Djouad team. Morpholinos against zebrafish #TRF2 induce macrophage #senescence and block fin regeneration. #Parabiosis, #MacrophageTracking & #Transcriptomics show #p16-high, and low pro-inflammation.
Go Fish! 🐟🐟🐟
www.thno.org/v15p7308.htm

Thank you, Kevin! Your work will be sorely missed... "So long and thanks for all the fish!" 🐟

Telomeric antisense oligonucleotides reduce premature aging phenotypes in telomerase mutant zebrafish - preLights Unlocking the Fountain of Youth: Inhibition of telomeric DNA damage response reduces premature aging in zebrafish

Unlocking the Fountain of Youth ⛲: Inhibition of telomeric DNA damage response reduces premature aging in #zebrafish

#preLight prepared by Jawdat Sandakly⬇️ 👀

prelights.biologists.com/highlights/t...

Highlights work from @miguelgf.bsky.social et al. 🐟

Thanks for the highlight, ‪@zebrafishrock.bsky.social‬! This is the first last author paper of Bruno Lopes-Bastos.
We are very happy for this!

Thanks for the highlight, ‪@zebrafishrock.bsky.social‬! This is the first last author manuscript of Bruno Lopes-Bastos.
We are very happy for this!

Join us in Lisbon for the GIMM Festival: #Aging and #Longevity, happening September 4–6! Explore the future of aging with 20+ invited international experts.
Secure your spot on: gimm.pt/gimm-festival/
@nataging.nature.com

Here’s the EMBO Journal highlight on our paper!

cGAS-STING are responsible for premature aging of telomerase-deficient zebrafish | The EMBO Journal imageimageTelomere erosion is a hallmark of aging, yet its downstream mechanisms and impact on organismal aging remain unclear. This study shows that cGAS-STING inflammatory signaling drives premature...

cGAS-STING are responsible for premature aging of telomerase-deficient zebrafish | The EMBO Journal www.embopress.org/doi/full/10....

cGAS-STING are responsible for premature aging of telomerase-deficient zebrafish | The EMBO Journal imageimageTelomere erosion is a hallmark of aging, yet its downstream mechanisms and impact on organismal aging remain unclear. This study shows that cGAS-STING inflammatory signaling drives premature aging in response to telomere shortening in ...

cGAS-STING are responsible for premature aging of telomerase-deficient zebrafish
www.embopress.org/doi/full/10....

It was a pleasure to invite our neighbour Corine BERTOLOTTO to IRCAN. It was a great review of the lab's work and a very nice return to Hopital Pasteur, Nice.

"Uveal melanomas: identification of new prognosis biomarkers and therapeutic targets"

A chart showing cancelled NIH grants

“I would like to cure brain cancer. I think that's not particularly controversial.” Be that as it may, the NIH terminated that scientist's grant. Here's a huge survey of the 2,500 grants that NIH has killed or delayed...so far. Gift link: nyti.ms/43Jz1yJ

TODAY - You are still on time for early bird registration for the GIMM Festival on #Aging and #Longevity!
Lisbon from 4–6 September 2025.

GIMM Fest | Aging and Longevity: Registrations open now! September 4-6 2025, Portugal, Lisbon. The brand new Gulbenkian Institute, launching – the very first GIMM Festival – "Aging and Longevity" to explore the future of aging through science. gimm.pt/gimm-festival/

Telomeric antisense oligonucleotides reduce premature aging phenotypes in telomerase mutant zebrafish Telomerase activity is restricted in somatic cells, resulting in progressive telomere shortening. Telomere erosion eventually activates the DNA damage response (DDR), inducing cell-cycle arrest and ce...

Our latest preprint!
We show that telomeric antisense oligonucleotides alleviate premature #aging in #telomerase mutant #zebrafish. A collaboration with the labs of Fabrizio d'Adda di Fagagna and Marina Mione.
Congrats Bruno for his first corresponding author paper!👏
www.biorxiv.org/content/10.1...

Europe can capture the US brain drain — if it acts fast Countries must cooperate to seize a once-in-a-generation opportunity to become the top destination for scientists.

"CERN (..) was created in the 1950s by physicists, who persuaded governments to invest in shared infrastructure and long-term collaboration. Now, it (...) thrives thanks to stable funding, open science and a culture of international partnership."
www.nature.com/articles/d41...

This is a fantastic symposium on the Biology of Aging organized by the GIMM in Lisbon next September 4-6, and with an opportunity for non-specialists to join the discussions. Stellar speaker lineup in beautiful Lisbon:
gimm.pt/gimm-festival/

Joao will be one of our discussion leaders!
Join us: Lisbon, 4–6 Sept 2025! 🇵🇹
👉 gimm.pt/gimm-festival/

Absolutely thrilled to join the @gimmfoundation.bsky.social GIMM Festival 2025 in Lisbon at the Pavilhão Portugal from 4-6 September 2025. What questions do we need to ask to build a unifying theory of aging? Join a great lineup of speakers to discuss concepts of the biology gimm.pt/gimm-festiva...

Join the GIMM Festival on #Aging and #Longevity! 🌟
Over three days, we’ll explore key questions:
1️⃣ Can we move toward a unifying theory of aging?
2️⃣ What are the top targets for longevity therapies?
3️⃣ How will aging research reshape society?
Lisbon, 4–6 Sept 2025! 🇵🇹
👉 gimm.pt/gimm-festival/

I am happy to contribute to this important initiative on how to improve #REPRODUCIBILITY in #AGING research using #zebrafish. Thank you ZHA for inviting me. Go Fish! 🐟

"Significantly, in HGPS, inhibition of the non-canonical cGAS-STING pathway ameliorates cellular hallmarks of aging, reduces tissue degeneration, and extends the lifespan of progeria mice." Congratulations! 👏

Image of several African turquoise killifish including a colorful male with red and silver scales with a yellow tail. Credit to Beate Hoppe.

🗣️ #killifish researchers & facilities: The community (led by Dr. Beate Hoppe @leibnizfli.bsky.social) is conducting an anonymous survey on husbandry of the African turquoise killifish (Nothobranchius furzeri) in hopes to standardize care & refinement. 🔗 to help: survey.lamapoll.de/Global-Surve...

Oxidative stress at telomeres triggers internal DNA loops, TRF1 dissociation, and TRF2-dependent R-loops Abstract. Telomeres are the nucleoprotein structures at chromosome ends. Telomeres are particularly sensitive to oxidative stress, which can induce telomer

"Altogether, our findings uncover in response to oxidative stress major remodelling of telomeric DNA, RNA, and shelterin complexes, and they unravel a physiological role of TRF2’s ability to stimulate TERRA R-loop formation."
From the Lingner and Doksani Labs 👏
academic.oup.com/nar/article/...

Gut metagenomes reveal interactions between dietary restriction, ageing and the microbiome in genetically diverse mice - Nature Microbiology Using a cohort of nearly 1,000 genetically diverse mice undergoing dietary restriction over the lifespan, the authors reveal numerous insights into the interactions between the gut microbiome, host ge...

😳 “Lastly, we find that the microbiome is associated with multiple health parameters, including body composition, immune components and frailty, but not lifespan.” #aging

www.nature.com/articles/s41...

A cautionary tale for the USA. "When national science funding becomes uncertain, researchers leave, new talent refrains from joining and infrastructure deteriorates."

www.nature.com/articles/d41...

Lifetime quotes.

Are you passionate about live-imaging microscopy? Do you have a special talent for working with iPSCs? Or are you simply a zebrafish aficionado? 🐟
We have 2 funded postdoctoral positions in our lab (cbi-toulouse.fr/eng/equipe-b...).
Join us and apply now!
Please spread the word 🙏

Somatic mutation as an explanation for epigenetic aging - Nature Aging Koch and colleagues report that epigenetic clocks mirror age predictions based on the accumulation of somatic mutations and show that somatic mutations at CpG sites coincide with extensive remodeling ...

Are the longevity crowd barking up the wrong tree because they have mistaken the chicken for the egg?

Evidence that epigenetic 'clocks' are driven by somatic mutations www.nature.com/articles/s43...

#biosky

Telomeric transposons are pervasive in linear bacterial genomes Eukaryotes have linear DNA and their telomeres are hotspots for transposons, which in some cases took over telomere maintenance. Here we identify several families of independently evolved telomeric tr...

"Eukaryotes have linear DNA and their telomeres are hotspots for transposons (...). Here we identify several families of independently evolved telomeric transposons in linear chromosomes and plasmids of cyanobacteria and Streptomyces."

www.science.org/doi/10.1126/...