Steve Jacobsen

Viral delivery of an RNA-guided genome editor for transgene-free germline editing in Arabidopsis - Nature Plants Weiss et al. engineered the tobacco rattle virus to express the RNA-guided TnpB enzyme ISYmu1 and guide RNA for transgene-free germline editing in Arabidopsis thaliana.

Our paper is just out www.nature.com/articles/s41... from the Jacobsen, Doudna, and Banfield labs on viral delivery of a tiny CRISPR system for transgene free germline editing in plants, tinyurl.com/3k223r3x. Looking for postdocs to join the team for the next phase of this work!

01.05.2025 14:24 — 👍 38    🔁 16    💬 0    📌 1

A photo of a mix of green and white Arabidopsis thaliana seedlings. They turn white when a particular gene is knocked out. Here, a tiny CRISPR system was used to modify the mother plant’s DNA, which the white seedlings inherited.

In a new paper, IGI's Jennifer Doudna @doudna-lab.bsky.social and Jill Banfield @banfieldlab.bsky.social collaborate with UCLA's @jacobsenucla.bsky.social to create a new, tiny #CRISPR tool for quicker, easier plant genome editing! Read more: ow.ly/6Szs50VGElf

24.04.2025 15:59 — 👍 15    🔁 3    💬 0    📌 0

Hi plant epigenetics fans!
I have updated the Plant Epigenetics Starter Pack to include additional researchers in the field:
@jacobsenucla.bsky.social @pecinka-grp.bsky.social @manavellalab.bsky.social
Please let me know if you wish to be added to the Starter Pack!
go.bsky.app/HyTwdc2

14.03.2025 12:34 — 👍 51    🔁 27    💬 3    📌 3

Transcription factors instruct DNA methylation patterns in plant reproductive tissues DNA methylation is maintained by forming self-reinforcing connections with other repressive chromatin modifications, resulting in stably silenced genes and transposons. However, these mechanisms fail ...

Back-to-back manuscripts from the Jacobsen and Law labs revealing TFs that direct RdDM! Genetics controlling epigenetics. Reminiscent of KRAB ZFs... shorturl.at/TE4PH shorturl.at/QEHDU

24.02.2025 20:59 — 👍 37    🔁 16    💬 0    📌 0