Tal Nuriel, PhD

Sex-specific factors and APOEε4 genotype alter functional connectivity at middle age Cognitive aging is influenced by sex and sex-specific factors. Indeed, research has shown that parity (pregnancy and parenthood) uniquely alters bioma…

While you are all waiting for treat or treaters & the blue jay game … take a look at our newest from
@bonniee-leee.bsky.social where we look at neural networks in middle aged female rats based on APOE genotype and parity history www.sciencedirect.com/science/arti...

Love it! Now I want to carve a pumpkin as a mouse brain, but I think it's too late.

Episode 23- Jenny Lange on the gothic history of neuroscience, a Halloween special

In the mood for something sciency and spooky? How about the Halloween special of @uclbrainstories.bsky.social - where me and @caswell.bsky.social talk to @drjlange.bsky.social on some of the gothic stories in neuroscience! 👻 🧠 🎃 💀🧟‍♂️

spotify.link/2lHT9pLQRXb

Don't worry folks! Pretty soon we'll go from having a 0% chance of getting grants (govt shutdown) to having a 5% chance of getting grants (continuing resolution and multi-year funding). But that's only temporary...eventually, it'll go back to the easy-peasy 10-15% funding lines we all know and love.

Very interesting

Yeah, would be interesting to see. I know that glucose uptake and mitochondrial respiration are issues with E4, but hadn’t thought much about how the neurons act when fatty acids are needed as fuel in E4 vs E3 brains

Yeah, would be interesting to see what the ephys looks like in a slice using glucose or palmitate as a fuel source. Would that be doable?

Seriously. Especially for APOE, you never see phenotypes like that.

That's a hell of a figure. www.alzforum.org/news/researc...

It’s an interesting area of research…using preclinical models of course.

It’s fascinating. For some reason, I had always thought about the dangers associated with preterm birth to be solely due to the underdevelopment of the baby…I hadn’t considered the different dangers that could occur based on how the baby is treated in the ICU after the birth.

Hmm. Reading about oxygen administration for preterm babies and the potential for hyperoxia and oxidative stress, and that is a topic that I’ve heard zero info about up until now.

Pushing through my skepticism to review these K99 and K01 applications I've been assigned. The good news is that there are some tremendous applicants that could contribute so much if given the chance. The bad news is that there's no way to give them a chance if the govt doesn't open back up.

Zalsupindole is a Nondissociative, Nonhallucinogenic Neuroplastogen with Therapeutic Effects Comparable to Ketamine and Psychedelics Many neuropsychiatric conditions, including depression, involve synaptic loss and atrophy of the prefrontal cortex. The rapid regrowth of cortical neurons has been hypothesized to explain the rapid an...

Big week for all you second-gen psychedelics and non-hallucinatory neuroplastogens fans! New results from Zalsupindole - promotes greater neuroplasticity than ketamine, psilocybin, or DMT, without any of the pesky psychedelic side (fun?) effects.

pubs.acs.org/doi/abs/10.1...

Is it sad that my first thought was: a five year cell culture experiment isn't that bad. There would still be two years left to finish up their PhD or postdoc 😭 😭https://www.alzforum.org/news/research-news/neurons-born-and-raised-organoids-act-their-age

Link to buy below. Even as a 43yo neuroscientist I enjoyed a lot! I mean… who wouldn’ love a book that has monkeys with robot arms & pirate kittens!

uk.bookshop.org/p/books/insi...

Thought I was getting an email saying the study sections are going to be postponed, but instead: “we ask that you continue your preparations for upcoming review meetings as best you can.” 🤷🏻‍♂️ ok, I’ll keep going

Hmm. Well, if that’s the case, they might as well cancel the study section

Yeah, mine are due Oct 27 for a Nov 5 review date. Just hard to focus on the reviews when I don’t believe the study section is going to happen

Currently reviewing grants for a study section that probably won't happen. Whose idea was it to link the success our scientific enterprise with the proper functioning of the federal government?

Assistant Professor: Center for Alzheimer’s Research Tenure-track Investigator, Brown University Center for Alzheimer’s Disease Research. Join Carney Institute exploring neurodegeneration and dementia.

Tenure-track Investigator Vacancy, Brown University Center for Alzheimer’s Disease Research. Join Carney Institute exploring neurodegeneration and dementia. Closing date: 1st November

www.dementiaresearcher.nihr.ac.uk/job/assistan...

PhD: Alzheimer’s risk in women, menopause, apoe & exercise PhD position, University of Manchester. Study how APOE genotype, menopause & exercise interact to influence vascular dysfunction & dementia risk in Alzheimer’s

PhD position, University of Manchester. Study how APOE genotype, menopause and exercise interact to influence vascular dysfunction and dementia risk in Alzheimer’s. Closing date: 8th November

www.dementiaresearcher.nihr.ac.uk/job/phd-alzh...

The 2nd of 6 faculty positions open at UNC Biology is for an Asst Professor studying critical questions in Plant Molecular Biology, focusing on molecular mechanisms illuminating fundamental aspects of plant biology, including interactions with other organisms 1/n
unc.peopleadmin.com/postings/307...

COVID-19 infection associated with increased risk of new-onset vascular dementia in adults ≥50 years - npj Dementia npj Dementia - COVID-19 infection associated with increased risk of new-onset vascular dementia in adults ≥50 years

Covid causes brain damage.

Edit: Covid causes serious long term brain damage, and here's a whole lot more data

"COVID-19 infection was associated with a 58% increased risk of all-cause dementia and a 105% increased risk of Vascular Dementia"

Free article:
www.nature.com/articles/s44...

Rocío is an amazing scientist, mentor, and person in general!!! Please share this job opening with anyone who might be interested 🤩🤩

Posting on behalf of Tamar Gollan, who is not on Bluesky:

A postdoc position is open and available immediately in Dr. Tamar Gollan’s Laboratory of Aging Bilingualism at the University of California, San Diego, funded by NIH & NSF. See link for details!

psychiatry.ucsd.edu/about/LAB_Go...

Attended a conference yesterday, and one of the speakers spent his whole talk airing his personal grievances about other scientists who he felt had wronged him throughout his career. Made me want to crawl out of my skin.

Very good point! I didn’t check the papers that were cited

They do cite a bunch of animal studies showing that acetaminophen (or its metabolites) can negatively impact brain development in mice, and they cite some proposed mechanisms (oxidative stress, prostaglandin or endocannabinoid system effects, endocrine system disruption).

Huntington's disease successfully treated for first time One of the most devastating diseases finally has a treatment that could transform lives, tearful doctors tell BBC

Wonderful news. A salutary reminder of the absolute benefits of scientific progress, and the absolute evil of conspiracist bollocks.

Huntington's disease successfully treated for first time www.bbc.com/news/article...