Is the sigmoid concentration curve really that big of a difference from the dose response curve? The linear curve certainly would be…

How?? Those are crazy HR’s

I mean. What? Do we believe this? Nothing works in dialysis except...fish oil?

Screening for iron deficiency: an analysis based on bone-marrow examinations and serum ferritin determinations in a population sample of women - PubMed Efficacy of different methods in screening for iron deficiency was re-examined in a randomly selected sample of 38-year-old women (n = 203) with known iron status based on absence/presence of stainabl...

pubmed.ncbi.nlm.nih.gov/7918045/

Clinical thresholds for diagnosing iron deficiency: comparison of functional assessment of serum ferritin to population based centiles - PubMed Low serum ferritin is diagnostic of iron deficiency, yet its published lower cut-off values are highly variable, particularly for pediatric populations. Lower cut-off values are commonly reported as 2...

I don’t know of any general history on the development of lab values but there’s literature in hematology on refining ferritin and anemia “normal” values… here’s a few studies if interested:
pubmed.ncbi.nlm.nih.gov/33106588/

pubmed.ncbi.nlm.nih.gov/31074518/

pubmed.ncbi.nlm.nih.gov/1487761/

SABA prn instead of SMART therapy for asthma?

Great negative predictor if normal

Should we take into account renin level when selecting an agent? (For non-PA).

If renin is low, would suggest ACE/ARB would be less efficacious, right? If high, RAASi more useful? Opposite true with diuretics? #nephjc

Age range expanded to 30-79 and more applicable to diverse populations, too! #nephjc

Is “Elevated BP” the best term for 120-129? HTN is elevated BP…. #nephjc

Why not everyone?? #nephjc

Would anyone be willing to share a pdf? No institutional access ☹️

Would you have given an anti-arrhythmic in that scenario or just lowered the K? If so, what would your ideal anti-arrhythmic been?

Everything is relative. Everything is subjective. Nothing in medicine is independent of interpretation

Why 1st HF hospitalization?

Wonderful study! Thanks for sharing.

I assume the absolute risk would be higher in a population with more cardiometabolic risk factors -> higher MACE incidence over time? This is a remarkably healthy cohort compared to the US patient population.

Our new data on subclinical PA and MACE is out in Circulation! For the first time, we show that renin-independant aldosterone production is associated with an increased risk of MACE independently of BP, in people mostly normotensive with low CV risk.
www.ahajournals.org/doi/full/10....

Is there any validated study that correlates X% decrease in UACR with Y% change in eGFR? Or any hard endpoints like RRT initiation, etc?

Emphasizes the need to make these drugs accessible

Why such few women?

Efficacy of Esaxerenone Plus a Renin-Angiotensin System Inhibitor or Calcium Channel Blocker for Nocturnal Hypertension: A Post Hoc Analysis - PubMed Esaxerenone when used in combination with a CCB or RASi, but especially when used in combination with a RASi, may be a useful treatment option for patients with uncontrolled hypertension to control no...

You’re right BP meds not addressing underlying cause, but maybe no difference in outcomes due to the medications used or population?
Have this study in mind: BP reduction for ns-MRA/RASi in nocturnal HTN in pts uncontrolled HTN (no assessment hard outcomes ☹️).
pubmed.ncbi.nlm.nih.gov/40178088/

Great figure!

Has pill measuring as a compliance metric been used in other studies? Is this more common in pediatric trials?

What a great study. Thanks for sharing

Able to make a downloaded pdf link available? No institutional access ☹️

Thanks for clarifying

Not much discussion on diastolic target in HTN…just “We do not recommend a specific diastolic BP target, given evidence that adults with a systolic BP < 130 mm Hg are at relatively low cardiovascular risk even when diastolic BP is 70–90 mm Hg”…
So <130/90 target BP for everyone?

The fallacy of time-to-intervention studies 0 Time and tide wait for no intervention                              - Geoffrey Chaucer  0 We are barraged by time-to-intervention studies

Aren’t time to intervention studies confounded and likely greatly overestimate the impact of early antibiotic administration?

Thanks for the thread!

emcrit.org/pulmcrit/the...

Can you share the source?

Polycystic Liver Disease