Julien Sage

It’s #moleratmonday, where we bring you a fun fact about the naked mole rat, every Monday 🐀 Last week we mentioned their long lifespans, but saved the best part for this week:

The current record for the oldest naked mole rat is 40 years old! It lived in the care of the Rochelle Buffenstein lab ❤️

Register to the Biological Methylation meeting!
June 15-18 in Dublin
Many award opportunities for trainees (see the award page)
Several talks selected from abstracts (deadline Apr 20)
Come listen to and share awesome science, meet colleagues and make new connections!
events.faseb.org/event/biolog...

We are hiring!

Multi-tissue transcriptomic aging atlas reveals predictive aging biomarkers in the killifish - Nature Aging Characterizing molecular aging features is crucial for understanding systemic and local factors contributing to the aging process. Here Costa, Chen et al. performed RNA sequencing on 13 tissues across...

Multi-organ transcriptomic aging atlas in killifish, with both males and females! 🐟🐟🐟

Huge congratulations to Emma, Jing, Tony and the entire team!! ✨⭐

@emkcosta.bsky.social
@jingxunchen.bsky.social
Wyss-Coray lab!

www.nature.com/articles/s43...

Targeting immune cells in the aged brain reveals that engineered cytokine IL-10 enhances neurogenesis and improves cognition Immune cells populate the old brain, but whether they can be specifically targeted to improve brain function in older individuals remains unclear. Navarro Negredo et al. dissect how aging impacts brai...

Excited to share our new study using engineered immune proteins to quench inflammation in aged brains!!

Congratulations to Paloma Navarro and the entire team!

Fantastic collaboration with Chris Garcia's lab, Tony Wyss-Coray's lab, and Saul Villeda's lab!

www.cell.com/immunity/ful...

It’s time for #moleratmonday, where we bring you a fun fact about the naked mole rat, and it’s also Monday 🐀 Today’s fact:

For a rodent, they have an incredibly long lifespan. It’s estimated to be ~10 years in the wild, and 30+ in captivity! The price: they’re super wrinkly even when they’re young

Reminder of a fantastic meeting coming up in July - FASEB Cell Cycle Regulation in Health and Disease. Note this meeting is also co-located with the FASEB Yeast Chromosome Biology Yeast Conference w/ shared poster session and joint talks. Please share!
events.faseb.org/event/cell-c...

Welcome back to #moleratmonday, where we tell you a fun fact about the naked mole rat every Monday! 🐀 Today’s fact:

They aren't really naked: Naked mole rats are covered with tactile hairs, concentrated in important areas like their face and toes. This helps make up for their very poor eyesight 👀

Thrilled to share the primary focus of my PhD thesis work, now out in @science.org today!

We developed Trikines — engineered cytokines that reconfigure receptor complex assembly to reshape signaling directly in endogenous immune cells.

t.co/UCixfysaUl

Very excited to organize the 2026 FASEB Conference: Chromatin and Epigenetics in Aging and Disease with Ashby Morrison, @bbparis1984.bsky.social , and Ernesto Guccione! Join us in Ireland this fall! Speaker slots are available and trainees are invited to a pre-meeting career development event.

Exciting to see that the conference is filling up fast! Don't dawdle and apply soon!

Welcome to #moleratmonday, where every Monday we'll share a fun fact about the naked mole rat! 🐀 Today's fact:

Naked mole rats are one of two eusocial mammals, meaning they live in colonies with a single breeding female, like bees 🐝 the other eusocial mammal? Also a mole rat!

#nakedmolerat

Very sad news. Gail Martin (1944-2026) was a figure in developmental biology. She pioneered the field of ES cells.
A great colleague, a friend and a lovely person.

We have posted a Research Assistant (LSRP1) position to work on aging and 'rejuvenation' using mouse models!! 🐭

careersearch.stanford.edu/jobs/life-sc...

Apply and join our awesome lab!! (please share) 😎

We are hiring!! Lab Assistant II position to work with the killifish! 🐟🐟🐟 This is an amazing model to study aging and 'suspended animation'

careersearch.stanford.edu/jobs/lab-ass...

Come and join our fantastic team at Stanford!! 🤩 Please share!

KLF4 promotes a KRT13+ hillock-like state in squamous lung cancer - PubMed Lung squamous cell carcinoma (LUSC) is basal-like subtype of lung cancer with limited treatment options. While prior studies have identified tumor-propagating cell states in squamous tumors, the broader landscape of intra-tumoral heterogeneity within LUSC remains poorly understood. Here, we employ S …

Transcriptional plasticity is a major barrier to effective cancer treatment. We know a lot about it in #SCLC but less is known for #squamous #lungcancer. Luke Izzo & Tony Reyes have made major inroads into this problem in our latest preprint:
pubmed.ncbi.nlm.nih.gov/40161723/

The Venkatesh lab is looking for a junior technician to join us this summer. If you are interested in working in cancer neuroscience, check out the job description below and see if it is a good fit for your goals!

www.linkedin.com/jobs/view/43...

Join us for an awesome Keystone Symposia in Banff, Canada in March 2026! Fantastic line up of speakers at the juncture between immunity and aging!! www.keystonesymposia.org/conferences/...

It is a PROBLEM that the new MANDATORY ScienCV platform does not (as far as I can tell) enable one to indicate co-first or co-senior authorship in your bibliography. This is a massive disincentive to collaborative science and it needs to be fixed.

Thrilled to share our deconstruction of a p53 therapeutic response in #LUAD- a step toward drugging #undruggable #p53! Thanks to our amazing team and to Cancer Discovery @aacrjournals.bsky.social!

Sign up date coming quickly!
Come join us in beautiful Roscoff for this Conference Jacques Monod on Developmental regulation: from molecular to ecological niches
May 18-22, 2026 Roscoff, France
Abstract deadline: January 31, 2026
Apply here: cjm.sb-roscoff.fr/en

Testing Nature’s Defenses: Inducing Cancer in the Naked Mole Rat url: aacrjournals.org/cancerdiscov...

Thanks @elizsmckenna.bsky.social and @aacrjournals.bsky.social for featuring our report!

It is with great sadness that I have learned of the unexpected passing of my postdoctoral mentor, Richard Hynes. Richard was far more than a mentor to me. He believed in me at a formative moment in… ... It is with great sadness that I have learned of the unexpected passing of my postdoctoral mentor, Richard Hynes. Richard was far more than a mentor to me. He believed in me at a formative moment in m...

www.linkedin.com/feed/update/...

🚨 PRECOG 2.0 is live! 🚨

I’m thrilled to share a major expansion of PRECOG, now online @narjournal.bsky.social.

PRECOG 2.0 at a glance:
📊 335 cancer datasets
🧬 46,000+ total patients
🩺 ~55 distinct malignancies

📖 Read the Paper: lnkd.in/gyiXSmCM
🌐 Explore the Data: lnkd.in/gZDsDEyG

⭐Check out this Comment published in the 2025 year-in-review @NatureCancer Focus Issue

✏️By Michelle Monje & Frank Winkler

'Key developments in the cancer neuroscience field'

🔗 www.nature.com/articles/s43...

Thanks to Dr. McNeely @phdmarie.bsky.social for profiling our work and putting together such an awesome podcast on scientists--the people behind the work. #STEM And now that #Basal and #Tuft are quasi famous.... will have to post them here. ;)

Excited to present our newest pre-print, “Bispecific T cell engagers control solid tumors through clonal replacement and IL2-driven effector differentiation of CD8 T cells.”

www.biorxiv.org/content/10.6...

Fantastic collaboration b/n the Satpathy, Sage, and Garcia labs at Stanford

Unambiguous (disappointing) results for oral semaglutide in the evoke trials. No impact on progressive deterioration of cognitive function #AlzheimersDisease sciencehub.novonordisk.com/congresses/c... 🧪

I’m excited to share a new postdoctoral opportunity in my lab at Stanford to study the consequences of gene dosage alterations in iPS cells. Check out the posting below and shoot me an email if you’re interested -

Conference: Neurogenesis from development to adulthood in health and disease The adult brain consists of billions of neurons that show an unimaginable complexity in their structural diversity and functional connectivity allowing for a plethora of brain functions. Notably…

Interested in neural stem cells and neurogenesis throughout lifespan?

Exciting meeting in 2026 in Switzerland!!

neuro-unige.ch/news/csf-mee...