We are delighted to host Harsha Kantamneni today from the University of Bradford.

"Endosomal Sorting Complex Required for Transport (ESCRT): Roles in receptor trafficking, signalling pathways, drug resistance and disease"

📍 Alfred Denny Conference Room

📅 18th October - 1pm

Senior Research Technician at University of Birmingham Explore an exciting academic career as a Senior Research Technician. Don't miss out on other academic jobs. Click to apply and explore more opportunities.

We are looking for a senior technician (can undertake PhD) at Uni of Birmingham (UK) to study chromatin replication and ubiquitylation using Xenopus egg extract. Deadline 28/10/25. Get in touch with me or @m-saponaro.bsky.social for informal inquiries. Please share.
www.jobs.ac.uk/job/DOW912/s...

Congratulations to Shahd on passing her PhD viva!!!!
Thanks to Christoph and Jason @jasonkinglab.bsky.social for examining

Amazing talk by Bella, from @helenkmatthews.bsky.social lab at #NECB2025

More fascinating talks this morning by our final year students Megan Poxon (@jasonkinglab.bsky.social & @helenkmatthews.bsky.social), Nada Alosaimi (C. Smythe lab), Zhe Bao (@erainerolab.bsky.social), @rlawson954.bsky.social @helenkmatthews.bsky.social) and Ashleigh Whelan (Wilson lab)

Great talks by our @mcb-sheffield.bsky.social speakers Grace Gilbert (@bose-lab.bsky.social & @tsakiridis.bsky.social), Francesca Brown (Humphreys lab) and Rob Hunton (@struttlab.bsky.social) at the 3rd year PGR symposium!! Back tomorrow morning - stay tuned!!

Here are our fantastic postdocs: Mona, Rachele & Eric
@mcb-sheffield.bsky.social
#NPAW2025
#PostdocAppreciationWeek

Well done to our PhD student @rlawson954.bsky.social 👏

on giving a talk on her data on keratins and mitotic mechanics at the MBI-MPG conference at @mbisg.bsky.social in Singapore!

@mcb-sheffield.bsky.social

Group Leader Career Development Fellowships - Dunn School Are you an early career researcher interested in the cell or molecular mechanisms underlying disease? Do you have an outstanding record and an innovative research plan?

Are you a postdoc interested in the mechanisms of disease?

Do you have a great record and an exciting vision?

Come and start your own lab @dunnschool.bsky.social by applying for sponsorship for early career fellowships.

Deadline 30th September...pass it on!

www.path.ox.ac.uk/work-with-us...

Sheffield Pancreatic Cancer Research Network - Events Upcoming Events

Interested in Pancreatic Cancer Research? We are gearing up to host our 7th Sheffield Pancreatic Cancer Research Network meeting!

Check out the details at: sites.google.com/sheffield.ac...

@mcb-sheffield.bsky.social @fohsheffield.bsky.social

Event carbon calculator - the Node I am excited to announce the release of our event carbon calculator, our latest resource to support the creation of sustainable events. Estimate your

Calling all meeting organizers… @biologists.bsky.social now have a calculator to estimate your event’s carbon footprint and to test various reduction scenarios.

thenode.biologists.com/event-carbon...

A picture of 3 rows of people on steps at the MRC LMB. From left to right - top row: Akaash, Vic, Lara - Middle row: Kerrie, Manu, Paddy - bottom row: Meg and Julie

🚨 JOB ALERT 🚨
We're hiring a Research Assistant – no PhD needed!
Join us to explore the molecular mechanisms of receptor sorting in endosomes.
Experience in protein expression/purification, cloning & cell culture desired 🧫🔬
Apply now 👉 www.nature.com/naturecareer...

#STEMCareers #ResearchJobs

It was a pleasure to visit @sheffielduni.bsky.social
last week presenting our work "Neutrophil metabolism faciliates metastasis by influencing immune & ECM landscapes" at @mcb-sheffield.bsky.social seminar series.Thanks @erainerolab.bsky.social for the invitation & all who made it a memorable visit

Sheffield Pancreatic Cancer Research Network Meet the Team

I am excited to share our new Sheffield Pancreatic Cancer Research Network website! Please check it out at... sites.google.com/sheffield.ac... @fohsheffield.bsky.social @mcb-sheffield.bsky.social

We are delighted to host @cassiejclarke.bsky.social
today from the @cruk-si.bsky.social!

"Neutrophil metabolism supports metastasis of mammary cancer by altering immune and extracellular matrix landscapes"

📍 Alfred Denny Conference Room
📅 10th June - 1pm

Research Associate (Cell Biology) at University of Sheffield An opportunity for an academic position as a Research Associate (Cell Biology) is available, as advertised on jobs.ac.uk. Apply now and explore other academic job openings.

📣 Postdoctoral position available!!!
Are you interested in translating molecular cell biology into potential cancer therapy?
This project will explore the role of EGFR trafficking in chemotherapy resistance in #breastcancer
🔬 Prof Liz Smythe lab
📅 Deadline: 3rd Jule
👇 www.jobs.ac.uk/job/DNJ622/r...

New addition to our lab's PhD Wall of Fame - Bian 🇸🇾
#WeAreInternational
@mcb-sheffield.bsky.social
@sheffielduni.bsky.social

CBP-IDRs regulate acetylation and gene expression. Intrinsically disordered regions (IDRs) have emerged as crucial regulators of protein function, allowing proteins to sense and respond to their environment. Creb binding protein (CBP) and EP300 (p300)...

Hot off the press for your Friday morning! 🔥 Our new (and highly revised!) preprint is out. It significantly expands on our previous work, unveiling exciting new data on how CBP's intrinsically disordered regions (IDRs) regulate genes.
Link to preprint: tinyurl.com/5npjkyps

#IDRs #condensates #CBP

Well done Bian!!

We are delighted to host @vickysanzmoreno.bsky.social today from the @icr.ac.uk!

"Biomechanical hallmarks and vulnerabilities of metastatic cancer cells"

📍 Alfred Denny Conference Room
📅 4th June - 1pm

@insigneoinstitute.bsky.social
@sheffielduni.bsky.social
@sheffielduni.bsky.social

Amazing talk by Ife at the @mcb-sheffield.bsky.social 2nd year PGR symposium

Bia doing a super job with her talk at the @mcb-sheffield.bsky.social 2nd year symposium!! 👏👏

Second year PGR symposium with @drn-sheffield.bsky.social!
Exciting day full of science 🧬

ADP-ribosylation of NuMA promotes DNA single-strand break repair and transcription Abugable et al. investigated the role of ADP-ribosylation in NuMA function during DNA repair. They demonstrate that ADP-ribosylation-deficient NuMA impairs repair kinetics and transcription and fails ...

📣 New paper alert!

The El-khamisy lab uncovered how a key protein, NuMA, helps repair damaged DNA and protect important control regions of our genome, especially after oxidative stress.

🛡️ Protecting the genome = protecting health.
www.cell.com/cell-reports...

Fantastic talk from @nicola-carruthers.bsky.social at today's @mcb-sheffield.bsky.social postdoc talk series! #CBP #RNAs #enhancers and everything in between- smashed it! 👏

Mechanical control of the alternative splicing factor PTBP1 regulates extracellular matrix stiffness induced proliferation and cell spreading - PubMed Cells sense mechanical cues and convert them into biochemical responses to regulate biological processes such as embryonic development, aging, cellular homeostasis, and disease progression. In this st...

📣 New paper alert!! From the Erdman lab in @cp-iscience.bsky.social

"Mechanical control of the alternative splicing factor PTBP1 regulates extracellular matrix stiffness induced proliferation and cell spreading".

pubmed.ncbi.nlm.nih.gov/40241749/

Liz Smythe is presenting her work at #TUOSCancerResearch away day

MCB external seminar today: Prof Deborah Tweedle @newcastleuni.bsky.social

"Neuroblastoma:The ultimate chameleon of cancer genetics"

📍 Alfred Denny Conference Room
📅 4th April - 1pm

MCB external seminar today: Dr Peter Martin @icr.ac.uk

"Mitotic Genome Stability:  The Key to Precision Cancer Therapy?"

📍 Alfred Denny Conference Room
📅 2nd April - 1pm

FEBS Press Metastatic progression is characterised by extensive remodelling of the extracellular matrix, primarily mediated by secreted proteases, including ADAMTS family members. Rainero and colleagues found t....

Excited to share that our latest paper is out today!!!
'The protease ADAMTS5 controls ovarian cancer cell invasion, downstream of Rab25' - great effort by Sherry and Rachele (1/6)
@febsj.bsky.social
@mcb-sheffield.bsky.social
febs.onlinelibrary.wiley.com/doi/full/10....