MOREL Lab / MEMBRAMICS research

Functional and Morphological Plasticity of the Endolysosomal System: Pigment Organelles at the Crossroads of Physiology and Pathology The morphodynamical plasticity of the endolysosomal system supports the formation and function of specialized intracellular compartments, as exemplified by the pigment organelles in skin cells. In ep....

onlinelibrary.wiley.com/doi/10.1111/...

Check out our last review on endolysosomal plasticity in pigment organelles biology by @laurasalavessa.bsky.social @delevoyecedric.bsky.social in @biologyofthecell.bsky.social !

very proud of @frengerquentin.bsky.social for his best oral presentation at European Intermediate Filaments 2025 congress! welldone Quentin! 👍

you still have this picture! 😍

my 78 (strat 😅) is still perfect!

no PRS anymore? 😘

@membramics-lab.bsky.social lab is in the spotlight at @inem-necker.bsky.social with a showcase of scientific photos from our researchers!

congrats @myckaelarouabah.bsky.social @carlaalemany.bsky.social and @dobrawaamiri.bsky.social

www.sciencedirect.com/science/arti...

check out the recent dispatch on endolysosomes and melano-biology interplay in @currentbiology.bsky.social by @delevoyecedric.bsky.social & @laurasalavessa.bsky.social from @membramics-lab.bsky.social

The Company of Biologists 100 logo to the left and QR code to the right. Portrait of David Stephens to the left, text to the right 100 extraordinary biologists David Stephens David Stephens was a Journal of Cell Science Editor from 2015-2024 and the JCS–David Stephens Prize for the best JCS paper is named for him. David was a Professor at the University of Bristol, UK, where he studied cilia, membrane and cytoskeleton dynamics. He also helped establish the UK Cilia and Centrosome Network. #100biologists #biologists100

We are featuring David Stephens, a former @jcellsci.bsky.social Editor, as an extraordinary biologist this week. The JCS-David Stephens Prize for the best JCS paper is also named after him. #100biologists

impressive piece of work @nadlerlab.bsky.social ! congrats!

Endosome–ER contact sites in phagophore formation Autophagy is a crucial ‘self-eating’ mechanism used by eukaryotic cells to degrade and recycle cytosolic materials. A recent study by Da Graça et al. reports that the dynamic mobilization of endosome–...

Endosome–ER contact sites in phagophore formation: Trends in Cell Biology www.cell.com/trends/cell-...

Check out the recent spotlight published in @cp-trendscellbio.bsky.social about our study on ER-endosome contacts in autophagy by @julianedagraca.bsky.social

soon your own ATG16L1 story @frengerquentin.bsky.social !

This work illustrates the importance of Rab11 membranes rewiring in response to viral stress, and the key role of PI3P/PI4P turnover in membrane reprogramming during cellular hijacking by the Influenza virus

huge congrats to @carlaalemany.bsky.social & @julianedagraca.bsky.social and collaborators!

(again!) new publication for @membramics-lab.bsky.social, by @carlaalemany.bsky.social & @julianedagraca.bsky.social

in collaboration with N Naffakh & JB Brault, we show that Influenza virus triggers an ATG16L1/Rab11 PI4P response at ER membrane for viral export

journals.plos.org/plosbiology/...

In details, we show that upon starvation, EERCS transiently stabilize at the omegasomal membrane and ER-exit sites, promoting local Ca²⁺ release and phase transition. Within EERCS confined interspace, Rab3A nanovesicles undergo homo-fusion, mediated by RAB3GAP, driving proto-phagophore assembly.

New publication by @julianedagraca.bsky.social @membramics-lab.bsky.social

We show that ER–endosome contact sites (EERCS) are essential for autophagosome biogenesis by creating a specialized environment in response to starvation.

www.cell.com/cell-reports...

👏🏼 Proud to see @julianedagraca.bsky.social, former PhD student at INEM, honored with the 2025 Beth Levine Thesis Prize for her outstanding work on autophagy, supervised by Etienne Morel @membramics-lab.bsky.social.

congrats (again) to @julianedagraca.bsky.social !

Master students farewell (we will miss you 🥲) and team-sport performing at #coursedesprincesses for @membramics-lab.bsky.social summer start!

(bravo Aurore, Laura R, Laura S, Dobrawa, Carla and even Juliane!)

@membramics-lab.bsky.social lab, summer version 😗

dear all! The Membrane Band (www.membraneband.com) will give a concert for the 30th Anniversary of the "Cell biology & Cancer Research Unit" (aka UMR144 for close friends) ‪of Curie Institute on Monday 23th fo June! @institutcurie.bsky.social

see you there?

Today was about celebrations! @julianedagraca.bsky.social spent the day in the lab, and we celebrated TWO accepted papers (...more news to come 😉...).

@membramics-lab.bsky.social is a lovely team, for sure.

huge congrats to our beloved @carlaalemany.bsky.social & @julianedagraca.bsky.social 🥲

yesterday, thanks to @delevoyecedric.bsky.social our lab had the chance to spend several hours with Mickey Marks to discuss about... membranes! great day for Science ✌️

Bethesda Declaration — STAND UP FOR SCIENCE Support NIH Staff Now!

www.standupforscience.net/bethesda-dec...

very nice talk by @laurasalavessa.bsky.social about membrane dynamics in cellular inter communication at @sbcf.bsky.social special day, in Paris! 👍

🎓 Doctorants & postdocs, présentez vos travaux à l'international avec le soutien de la SBCF !

📅 Candidature avant le 15 juin 2025

🔗 sbcf.fr/fellowship/b...

#SBCF #BourseVoyage #BiologieCellulaire

Summer Fight For Science 2025 — STAND UP FOR SCIENCE

www.standupforscience.net/summer-fight...

Cell polarity and membrane dynamics The ability of cells to polarize is essential for organismal development and physiology, and its impairment underlies numerous diseases. The establishment and maintenance of cell polarity requires a …

check out there meetings.embo.org/event/25-cel...

@membramics-lab.bsky.social is having a great time (science, sun and sea) at EMBO workshop #cellpolarity2025 on membrane dynamics & cell polarity!

great job @franbottanelli.bsky.social👍!

This month’s #ParisPostdocsSeminar features @laurasalavessa.bsky.social from @inem-necker.bsky.social, presenting her latest results on the transfer and uptake of melanin in keratinocytes for skin homeostasis!

📅 Tuesday, 27 May 2025
🕚 11:00–12:00 CET
📍 Amphitheatre Agnès Ullmann, @pasteur.fr

To close the meeting, great talk of Juliane Da Graça, winner of the 2025 thesis prize, presented her work on the role of endosome-endoplasmic reticulum membrane contact sites in autophagy regulation in normal and cancer cells.