Barbara Marte

Clues to why the weight-loss condition cachexia arises when cancer occurs Analyses of RNA expression reveal molecules underpinning the cancer-associated process of skeletal-muscle wasting, a condition called cachexia.

a new News & Views out in Nature www.nature.com/articles/d41...

SPP1 is required for maintaining mesenchymal cell fate in pancreatic cancer - Nature Mutual paracrine regulation of the cytokines GREM1 and SPP1 mediate mesenchymal and epithelial cell fate in pancreatic cancer.

new out in Nature www.nature.com/articles/s41...

A drug–diet combination could improve childhood cancer treatment Mouse studies show that depriving neuroblastoma of certain amino acids causes a switch in protein synthesis to suppress tumour growth and promote cell differentiation.

and the News & Views www.nature.com/articles/d41...

Reprogramming neuroblastoma by diet-enhanced polyamine depletion - Nature Enhanced polyamine depletion in neuroblastoma models decreases translation of mRNA codons with adenosine in the third position, reprogramming the tumour proteome away from cell cycle progression and towards differentiation.

new out in Nature www.nature.com/articles/s41...

Boosting immune cells to combat cancer using CRISPR engineering and large-scale in vivo testing Immune cells can target cancer in the clinic. The ability to test a gene-editing technology in mice on a large scale should improve such immunotherapies.

and the News & Views www.nature.com/articles/d41...

In vivo CRISPR screens identify modifiers of CAR T cell function in myeloma - Nature In vivo loss-of-function CRISPR screens were performed to identify genes influencing CAR T cell persistence and function in human multiple myeloma, highlighting CDKN1B as a promising target.

new out in Nature www.nature.com/articles/s41...

Systematic discovery of CRISPR-boosted CAR T cell immunotherapies - Nature CELLFIE, a CRISPR platform for optimizing cell-based immunotherapies, identifies gene knockouts that enhance CAR T cell efficacy using in vitro and in vivo screens.

new out in Nature www.nature.com/articles/s41...

Will Dunn is right. An awful new trend. Lovely column.

We are thrilled to present a special September issue highlighting recent methods in the field of cancer biology.

www.nature.com/articles/s41...

Tipsy bats and perfect pasta: Ig Nobels celebrate ‘improbable’ research The annual awards are a celebration of weird but thought-provoking science.

this is fun www.nature.com/articles/d41...

Basal cell of origin resolves neuroendocrine–tuft lineage plasticity in cancer - Nature Basal cells, rather than neuroendocrine cells, have been identified as the probable origin of small cell lung cancer and other neuroendocrine–tuft cancers, explaining neuroendocrine–tuft heterogeneity...

new out in Nature www.nature.com/articles/s41...

Wired for growth: neuron–tumour signalling in the lung and brain increases growth of a hard-to-treat cancer Signalling between neurons and tumour cells in the lung and brain promotes the growth of small-cell lung cancer. These interactions might be a therapeutic target.

with a bit of delay, a new News & Views out in Nature www.nature.com/articles/d41...

Neuronal activity-dependent mechanisms of small cell lung cancer pathogenesis - Nature Glutamatergic and GABAergic (γ-aminobutyric acid-producing) cortical neuronal activity drives proliferation of small lung cell cancer via paracrine interactions and through synapses formed with tumour...

2. www.nature.com/articles/s41...

Functional synapses between neurons and small cell lung cancer - Nature Small cell lung cancer cells form functional synapses with glutamatergic neurons, receiving synaptic transmissions and deriving a proliferative advantage from these interactions.

and last but not least two cancer neuroscience papers on small cell lung cancer. 1. www.nature.com/articles/s41...

Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumours - Nature An understanding of the molecular mechanisms promoting the generation of immunoregulatory and tumour-promoting monocytes and macrophages is key to breaking the cycle of tumour myelopoiesis and develop...

new out in Nature www.nature.com/articles/s41...

Molecular subtypes of human skeletal muscle in cancer cachexia - Nature Unbiased clustering analysis of the skeletal muscle RNAome in patients with cancer identifies two molecular subtypes, one of which distinguishes individuals with cachexia and indicates ...

new out in Nature www.nature.com/articles/s41... (the News & Views will come soon)

Epigenetic clues from cancer’s past foretell its future An innovative method to trace tumour evolution using patterns of fluctuating DNA modifications could be implemented in the clinic to predict cancer progression.

and the News & Views
www.nature.com/articles/d41...

Fluctuating DNA methylation tracks cancer evolution at clinical scale - Nature Cancer evolutionary dynamics are quantitatively inferred using a method, EVOFLUx, applied to fluctuating DNA methylation.

new out in Nature www.nature.com/articles/s41...

the deadline to register at the inaugural EACR cancer neuroscience is approaching fast: Sept 15th. Do join us for a fantastic line up of invited speakers, short talks and abstracts (yes, we have seen them) in the wonderful city of Bilbao (Guggenheim, Pintxos, Txakoli...). eacr.org/conference/c....

Compression causes cancer cells to start spreading The switch between proliferation and invasion is triggered by mechanical force.

new out in Nature www.nature.com/articles/d41...

Depriving brain tumours of an amino acid could enhance chemotherapy Glioblastoma, an aggressive brain cancer, depends on the amino acid serine as a fuel source. A serine-deficient diet has been shown to slow tumour growth in mice.

and the News & Views www.nature.com/articles/d41...

Rewiring of cortical glucose metabolism fuels human brain cancer growth - Nature The cortex fuels essential physiological processes with glucose-derived carbon, while gliomas fuel their aggressiveness by rerouting glucose carbon pathways and scavenging alternative carbon sources s...

new out in Nature www.nature.com/articles/s41...

Mechanical confinement governs phenotypic plasticity in melanoma - Nature Mechanical confinement of cancer cells at the tumour–microenvironment interface induces phenotype switching through chromatin remodelling by HMGB2, leading to a more invasive and drug-resistant state ...

new out in Nature this week www.nature.com/articles/s41...

Axonal injury is a targetable driver of glioblastoma progression - Nature Axonal injury, induced in the white matter by expansion of early tumour cells, is a key driver of glioblastoma progression.

new out in Nature www.nature.com/articles/s41...

Immunotherapy using CAR T cells shows promising long-term outcomes for people with the blood cancer myeloma A clinical trial reports data from one of the first groups of people with the blood cancer myeloma to receive a type of immunotherapy called CAR T cells.

a News & Views on a recent JCO paper www.nature.com/articles/d41...

Exercise improves survival of some people with colon cancer, clinical trial shows Most studies on how exercise affects the survival of people with cancer have been observational. A clinical trial provides compelling evidence of the benefits of physical activity.

just out this News & Views on a recent NEJM paper
www.nature.com/articles/d41...

Anticancer compounds that exploit a compromised checkpoint in the cell cycle In E2F-driven cancers, inhibitors of proteins called cyclins paradoxically cause cell death by enhancing the activity of cyclin B.

and the Research Briefing to go with it
www.nature.com/articles/d41...

Targeting G1–S-checkpoint-compromised cancers with cyclin A/B RxL inhibitors - Nature Dual cyclin A/B RxL inhibitors selectively kill small cell lung cancer cells and other cancer cells with high E2F activity.

new out in Nature
www.nature.com/articles/s41...

Cancer-induced nerve injury promotes resistance to anti-PD-1 therapy - Nature Perineural invasion and cancer-induced nerve injury of tumour-associated nerves are associated with poor response to anti-PD-1 therapy, which can be reversed by combining anti-PD-1 therapy with a...

new out in Nature www.nature.com/articles/s41...

Clone copy number diversity is linked to survival in lung cancer - Nature A study presents ALPACA, a computational method for inferring clone- and allele-specific copy numbers of individual clones from multi-sample bulk DNA-sequencing data, and demonstrates its use to study...

new out in Nature yesterday www.nature.com/articles/s41...