Barbara Marte

new out in Nature www.nature.com/articles/s41...

Order in which cancer-driving mutations occur affects the chance of tumour development Randomly acquired mutations face strong negative selection, except on certain cancer-promoting backgrounds.

and the Research Briefing to go with it www.nature.com/articles/d41...

new out in Nature www.nature.com/articles/s41...

new out in Nature www.nature.com/articles/s41...

Inhibitory PD-1 axis maintains high-avidity stem-like CD8+ T cells - Nature PD-1 blockade interferes with the selective expansion and maintenance of high-affinity TCR stem-like clones that have a critical role in effective checkpoint blockade therapy.

new out in Nature www.nature.com/articles/s41...

NSD2 targeting reverses plasticity and drug resistance in prostate cancer - Nature Inhibition of the histone methyltransferase NSD2 and the androgen receptor in preclinical models can reverse lineage plasticity to suppress tumour growth and promote cell death in multiple subtypes of...

new out in Nature www.nature.com/articles/s41...

Cover of this week's Nature showing a brain rendering Cover caption from the journal: Brain development: Our ability to process information into complex emotions, behaviours and decisions relies on the rich diversity of cell types that make up the human brain. Uncovering the molecular and cellular events that take place during brain development could reveal not only the mechanisms that give rise to this diversity but also shed light on how this process might go awry in neurodevelopmental disorders such as autism and schizophrenia. In this week’s issue, the BRAIN Initiative Cell Atlas Network (BICAN) builds on its previous work creating atlases of cell types in the adult mouse, non-human primate (NHP) and human brains to present cell-type atlases of the developing human, mouse and NHP brains. Across a suite of papers, nine of which are published in Nature, the researchers uncover the complex programs through which cell types emerge during brain development in humans and animals, revealing both the shared and unique features of the human brain. The latest work, along with future research directions, is summed up in a Perspective article by Tomasz Nowakowski and colleagues

New issue of Nature - with NINE studies on #brain #development from the BRAIN Initiative Cell Atlas Network (BICAN) 🧠🧪🔬

An amazing set of resources for all scientists working on the brain!

🧠 Immersive feature:
www.nature.com/immersive/d4...

🧠 Perspective:
www.nature.com/articles/s41...

Anti-progestin therapy targets hallmarks of breast cancer risk Nature - Results of an early-phase breast cancer prevention trial demonstrate the potential for breast cancer prevention in premenopausal women with anti-progestin therapy by inducing...

Really happy to share a link to our work showing that anti-progestin therapy could help prevent breast cancer before menopause.
Published today in Nature, the study suggests this could be a new way to stop breast cancer before it starts: urldefense.com/v3/__https:/...
Brilliant team science

BICAN: A cell census of the developing human brain Building on their landmark efforts to create cell-type atlases of adult brains using single-cell and spatial genomics technologies, researchers in the BRAIN ...

Draft atlases of the developing brain of humans and other mammals are presented in a collection of papers from BICAN published in Nature. These resources combine single-cell and spatial technologies to track how brain cell types emerge, diversify, and organize during development. 🧪

BICAN: A cell census of the developing human brain Building on their landmark efforts to create cell-type atlases of adult brains using single-cell and spatial genomics technologies, researchers in the BRAIN ...

new out in Nature: BICAN: A cell census of the developing human brain
www.nature.com/collections/...

Anti-progestin therapy targets hallmarks of breast cancer risk - Nature Results of an early-phase breast cancer prevention trial demonstrate the potential for breast cancer prevention in premenopausal women with anti-progestin therapy by inducing epithelial–stromal remode...

new out in Nature, the Breast Cancer-Anti-Progestin Prevention Study 1 (BC-APPS1; NCT02408770)
www.nature.com/articles/s41...

Targeting FSP1 triggers ferroptosis in lung cancer - Nature The ferroptosis suppressor protein FSP1 has a critical role in ferroptosis protection of tumours across multiple in vivo models and is linked to worse prognosis in human lung adenocarcinoma, suggestin...

new out in Nature, targeting FSP1 to trigger ferroptosis
www.nature.com/articles/s41...
www.nature.com/articles/s41...

From MRI to Ozempic: breakthroughs that show why fundamental research must be protected In these financially straitened times, funders must recognize that great discoveries often arise from work that was looking for something completely different.

In praise of fundamental research
Our editorial this week argues that I n these financially straitened times, funders must recognize that great discoveries often arise from work that was looking for something completely different
🧪
@nature.com
www.nature.com/articles/d41...

The sci-fi films that physicists love to watch — from Interstellar to Spider-Man Nature surveyed scientists about their favourite cinematic moments to celebrate the International Year of Quantum Science and Technology.

We asked physicists which are the sci-fi films they like the most - two were consistently highlighted in interviews for their depictions of science: 2014’s Interstellar and 2006’s The Prestige — both of which were directed and co-written by Christopher Nolan
🧪
www.nature.com/articles/d41...

People with some cancers live longer after a COVID vaccine mRNA vaccines seem to boost the effectiveness of an immune therapy for skin and lung cancer ― in an unexpected way.

and the News story www.nature.com/articles/d41...

Tumours might be sensitized to immune therapy by COVID mRNA vaccines COVID vaccines enhance the antitumour response of immunotherapies and result in increased patient survival.

and the Clinical Briefing www.nature.com/articles/d41...

SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade - Nature mRNA vaccines targeting SARS-CoV-2 also sensitize tumours to immune checkpoint inhibitors.

new out in Nature www.nature.com/articles/s41...

Pancreatic cancer relies on opposing signalling pathways to drive its cellular diversity Communication between epithelial and mesenchymal cells in pancreatic cancer leads to a poor prognosis. The molecular basis for this signalling has now been revealed.

new out in Nature, a News & Views www.nature.com/articles/d41...

Tumors are complex ecosystems, where #cancer and non-cancer cells interact, shaping how tumors grow, evolve, and respond to treatment. At #THPT25, Prof. Itay Tirosh will reveal the secrets to fighting back smarter. Want to join this fight? Register before the deadline on 26 Nov: vibbio.tech/49aIDGS

new out in Nature www.nature.com/articles/s41...

John Gurdon obituary: Biologist who made cloning possible He showed that specialized cells retain the genes to form an organism.

new out in Nature www.nature.com/articles/d41...

new out in Nature www.nature.com/articles/s41...

it was a pleasure! Thanks everyone for attending and contributing. And a big thanks to the EACR staff !

Clues to why the weight-loss condition cachexia arises when cancer occurs Analyses of RNA expression reveal molecules underpinning the cancer-associated process of skeletal-muscle wasting, a condition called cachexia.

a new News & Views out in Nature www.nature.com/articles/d41...

SPP1 is required for maintaining mesenchymal cell fate in pancreatic cancer - Nature Mutual paracrine regulation of the cytokines GREM1 and SPP1 mediate mesenchymal and epithelial cell fate in pancreatic cancer.

new out in Nature www.nature.com/articles/s41...

A drug–diet combination could improve childhood cancer treatment Mouse studies show that depriving neuroblastoma of certain amino acids causes a switch in protein synthesis to suppress tumour growth and promote cell differentiation.

and the News & Views www.nature.com/articles/d41...

Reprogramming neuroblastoma by diet-enhanced polyamine depletion - Nature Enhanced polyamine depletion in neuroblastoma models decreases translation of mRNA codons with adenosine in the third position, reprogramming the tumour proteome away from cell cycle progression and towards differentiation.

new out in Nature www.nature.com/articles/s41...

Boosting immune cells to combat cancer using CRISPR engineering and large-scale in vivo testing Immune cells can target cancer in the clinic. The ability to test a gene-editing technology in mice on a large scale should improve such immunotherapies.

and the News & Views www.nature.com/articles/d41...

In vivo CRISPR screens identify modifiers of CAR T cell function in myeloma - Nature In vivo loss-of-function CRISPR screens were performed to identify genes influencing CAR T cell persistence and function in human multiple myeloma, highlighting CDKN1B as a promising target.

new out in Nature www.nature.com/articles/s41...

Systematic discovery of CRISPR-boosted CAR T cell immunotherapies - Nature CELLFIE, a CRISPR platform for optimizing cell-based immunotherapies, identifies gene knockouts that enhance CAR T cell efficacy using in vitro and in vivo screens.

new out in Nature www.nature.com/articles/s41...