Barbara Marte

A disease model resource reveals core principles of tissue-specific cancer evolution - Nature The Mouse Cancer Cell line Atlas (MCCA) provides major advances towards a mechanistic understanding of cancer genomes.

new out in Nature www.nature.com/articles/s41...

OR7A10 GPCR engineering boosts CAR-NK therapy against solid tumours - Nature The identification of ‘boosters’ that drive gene overexpression directly in a CAR construct provides a simple and scalable strategy for developing effective CAR-NK cell therapies for solid tumours.

new out in Nature www.nature.com/articles/s41...

SLAMF6 as a drug-targetable suppressor of T cell immunity against cancer - Nature SLAMF6 functions exclusively as a T cell inhibitory receptor, which is triggered by cis homotypic interactions.

new out in Nature www.nature.com/articles/s41...

Activated ATF6α is a hepatic tumour driver restricting immunosurveillance - Nature ATF6α activation in human and preclinical models of hepatocellular carcinoma is significantly associated with an aggressive tumour phenotype characterized by reduced survival, glycolytic reprogramming...

new out in Nature www.nature.com/articles/s41...

ZFTA–RELA ependymomas make itaconate to epigenetically drive fusion expression - Nature The ZFTA–RELA fusion, an oncogene for ependymomas, promotes the production of itaconate, and its dependence on this metabolite represents a new therapeutic target for this cancer.

new out in Nature www.nature.com/articles/s41...

How tumours trick the brain into shutting down cancer-fighting cells Lung cancer in mice hijacks neurons to send a signal that subdues the immune system, study finds.

and the new story www.nature.com/articles/d41...

A tumour-to-brain pathway hinders anticancer defences Sensory neurons detect internal and external cues in organs and send this information to the brain. Lung cancer exploits this pathway to lessen immune responses.

and the News & Views
www.nature.com/articles/d41...

Tumour–brain crosstalk restrains cancer immunity via a sensory–sympathetic axis - Nature Mouse models demonstrate that vagal sensory neurons transmit signals from lung adenocarcinoma to the brain, increasing sympathetic efferent activity in the tumour microenvironment and thereb...

new out in Nature, very nice cancer neuroscience story
www.nature.com/articles/s41...

Critical role for a high-plasticity cell state in lung cancer - Nature The high-plasticity cell state (HPCS) is a critical hub that enables reciprocal transitions between cancer cell states, and targeting the HPCS may suppress cancer progression and eradicate treatment r...

new out in Nature www.nature.com/articles/s41...

Temporal tissue dynamics from a spatial snapshot - Nature One-shot tissue dynamics reconstruction can infer changes in tissue composition over time, from single-time-point spatial proteomics of human cancers.

new out in Nature www.nature.com/articles/s41...

new out in Nature www.nature.com/articles/s41...

and the News & Views
www.nature.com/articles/d41...

Nutrient requirements of organ-specific metastasis in breast cancer - Nature How the complex interplay between multiple nutrients within the microenvironment dictates potential sites of metastatic cancer growth is explored.

new out in Nature www.nature.com/articles/s41...

How fasting boosts breast cancer therapy A discovery in mice reveals why fasting enhances a type of breast cancer treatment — a hormone-signalling pathway and gene-expression changes have key roles.

new News & Views out in Nature
www.nature.com/articles/d41... on last week's www.nature.com/articles/s41...

Agonists for cytosolic bacterial receptor ALPK1 induce antitumour immunity - Nature The ALPK1 agonist UDSP-Hep stimulates tumour-cell antigen presentation, macrophage–DC cross-priming and differentiation of protective memory T cells.

new out in Nature this week www.nature.com/articles/s41...

Somatic evolution following cancer treatment in normal tissue - Nature High-depth sequencing of non-cancerous tissue from patients with metastatic cancer reveals single-base mutational signatures of alcohol, smoking and cancer treatments, and reveals how exogenous factor...

new out in Nature this week www.nature.com/articles/s41...

Uncovering the role of LINE-1 in the evolution of lung adenocarcinoma - Nature Lung adenocarcinomas bearing the ID2 mutational signature display increased LINE-1 retrotransposon activity, which contributes to their fast evolutionary dynamics and aggressive phenotype.

new out in Nature this week www.nature.com/articles/s41...

Fasting boosts breast cancer therapy efficacy via glucocorticoid activation - Nature Beneficial effects of fasting combined with endocrine therapy for oestrogen receptor-α-expressing breast cancers can be recapitulated using exogenous glucocorticoid receptor ligands instead of fasting...

new out in Nature this week www.nature.com/articles/s41...

new out in Nature www.nature.com/articles/s41...

Order in which cancer-driving mutations occur affects the chance of tumour development Randomly acquired mutations face strong negative selection, except on certain cancer-promoting backgrounds.

and the Research Briefing to go with it www.nature.com/articles/d41...

new out in Nature www.nature.com/articles/s41...

new out in Nature www.nature.com/articles/s41...

Inhibitory PD-1 axis maintains high-avidity stem-like CD8+ T cells - Nature PD-1 blockade interferes with the selective expansion and maintenance of high-affinity TCR stem-like clones that have a critical role in effective checkpoint blockade therapy.

new out in Nature www.nature.com/articles/s41...

NSD2 targeting reverses plasticity and drug resistance in prostate cancer - Nature Inhibition of the histone methyltransferase NSD2 and the androgen receptor in preclinical models can reverse lineage plasticity to suppress tumour growth and promote cell death in multiple subtypes of...

new out in Nature www.nature.com/articles/s41...

Cover of this week's Nature showing a brain rendering Cover caption from the journal: Brain development: Our ability to process information into complex emotions, behaviours and decisions relies on the rich diversity of cell types that make up the human brain. Uncovering the molecular and cellular events that take place during brain development could reveal not only the mechanisms that give rise to this diversity but also shed light on how this process might go awry in neurodevelopmental disorders such as autism and schizophrenia. In this week’s issue, the BRAIN Initiative Cell Atlas Network (BICAN) builds on its previous work creating atlases of cell types in the adult mouse, non-human primate (NHP) and human brains to present cell-type atlases of the developing human, mouse and NHP brains. Across a suite of papers, nine of which are published in Nature, the researchers uncover the complex programs through which cell types emerge during brain development in humans and animals, revealing both the shared and unique features of the human brain. The latest work, along with future research directions, is summed up in a Perspective article by Tomasz Nowakowski and colleagues

New issue of Nature - with NINE studies on #brain #development from the BRAIN Initiative Cell Atlas Network (BICAN) 🧠🧪🔬

An amazing set of resources for all scientists working on the brain!

🧠 Immersive feature:
www.nature.com/immersive/d4...

🧠 Perspective:
www.nature.com/articles/s41...

Anti-progestin therapy targets hallmarks of breast cancer risk Nature - Results of an early-phase breast cancer prevention trial demonstrate the potential for breast cancer prevention in premenopausal women with anti-progestin therapy by inducing...

Really happy to share a link to our work showing that anti-progestin therapy could help prevent breast cancer before menopause.
Published today in Nature, the study suggests this could be a new way to stop breast cancer before it starts: urldefense.com/v3/__https:/...
Brilliant team science

BICAN: A cell census of the developing human brain Building on their landmark efforts to create cell-type atlases of adult brains using single-cell and spatial genomics technologies, researchers in the BRAIN ...

Draft atlases of the developing brain of humans and other mammals are presented in a collection of papers from BICAN published in Nature. These resources combine single-cell and spatial technologies to track how brain cell types emerge, diversify, and organize during development. 🧪

BICAN: A cell census of the developing human brain Building on their landmark efforts to create cell-type atlases of adult brains using single-cell and spatial genomics technologies, researchers in the BRAIN ...

new out in Nature: BICAN: A cell census of the developing human brain
www.nature.com/collections/...

Anti-progestin therapy targets hallmarks of breast cancer risk - Nature Results of an early-phase breast cancer prevention trial demonstrate the potential for breast cancer prevention in premenopausal women with anti-progestin therapy by inducing epithelial–stromal remode...

new out in Nature, the Breast Cancer-Anti-Progestin Prevention Study 1 (BC-APPS1; NCT02408770)
www.nature.com/articles/s41...

Targeting FSP1 triggers ferroptosis in lung cancer - Nature The ferroptosis suppressor protein FSP1 has a critical role in ferroptosis protection of tumours across multiple in vivo models and is linked to worse prognosis in human lung adenocarcinoma, suggestin...

new out in Nature, targeting FSP1 to trigger ferroptosis
www.nature.com/articles/s41...
www.nature.com/articles/s41...