Ryan Englander

THIS IS HUGE! Researchers at The Jackson Laboratory and UConn Health have successfully discovered a molecular switch that can actually SHUT DOWN cancer growth signals and STOP tumor growth at the RNA LEVEL. The discovery could pave the way for a groundbreaking RNA-based multi-cancer treatment. 🧪🧵⬇️

Antisense oligonucleotide-mediated TRA2β poison exon inclusion induces the expression of a lncRNA with anti-tumor effects Nature Communications - The oncogenic splicing factor TRA2β is reported to be upregulated in human cancers partly by increased TRA2β poison exon (PE) skipping. Here the authors show that...

Our latest work on targeting the poison exon in #RNA #splicing factor TRA2B in #cancer reveals a role for this non coding transcript and opportunities for targeting splicing factor levels across multiple tumor types
rdcu.be/d90Ra
#RNAsky @jacksonlab.bsky.social

Intratumoral immune triads are required for immunotherapy-mediated elimination of solid tumors Tumor-specific CD8+ T cells are dysfunctional within tumors. Espinosa-Carrasco et al. show that CD4+ T cells must engage with CD8+ T cells on the same antigen-presenting cell (APC) during the effector phase, forming a three-cell-cluster (triad) to license CD8+ T cell cytotoxicity and CD8+ T cell-mediated cancer cell elimination.

www.cell.com/cancer-cell/...

Such a cool paper!!!

Spatial proteomics identifies JAKi as treatment for a lethal skin disease Nature - Cell-type-resolved spatial proteomics of the skin from patients with toxic epidermal necrolysis reveals that it is driven by JAK/STAT signaling, leading to successful treatment of this...

This is a cool story - spatial proteomics to identify over-expressed pathways (type I IFN & JAK/STAT) proposing new therapies (JAKi) for Toxic Epidermal Necrolysis

🌟 Discovery science translated into clincial benfit. Love it! 🌟

#MedSky 🧪 #ImmunoSky #dermatology
www.nature.com/artic...

A splicing isoform of PD-1 promotes tumor progression as a potential immune checkpoint - Nature Communications Whether PD-1 splicing isoforms impact T cell anti-tumor capacity has not been fully illustrated. Here the authors identify a human PD-1 isoform, PD-1^28, which functions to suppress anti-cancer immuni...

"Here, we identify an alternative splicing isoform of human PD-1, which carries a 28-base pairs extension retained from 5′ region of intron 2 (PD-1^28), is expressed in peripheral T cells and tumor infiltrating lymphocytes."
#Immunology #Immunotherapy
www.nature.com/articles/s41...

Complementation of a human disease phenotype in vitro by intercellular mRNA transfer https://www.biorxiv.org/content/10.1101/2024.11.06.622258v1 There is growing evidence that full-length mRNAs undergo intercellular transfer through long, thin c

Complementation of a human disease phenotype in vitro by intercellular mRNA transfer https://www.biorxiv.org/content/10.1101/2024.11.06.622258v1