Andrew Zalesky

My paper reviewing how different neurodegenerative diseases affect autonomic function was just published.

Our cover is now live at Nature Neuroscience @natureneuro.bsky.social !

Stimulation mapping and whole-brain modeling reveal gradients of excitability and recurrence in cortical networks - Nature Communications How brain networks organize and interact based on their hierarchical position remains poorly understood. Momi, Wang et al find that high-order brain networks show stronger responses to stimulation and...

Absolutely incredible work by Davide Momi, John Griffiths,and a stellar team of neuroscientists with a multidimensional view of brain dynamics.

This work gives us a WHOLE BRAIN map of excitability.

www.nature.com/articles/s41...

Human lifespan changes in the brain’s functional connectome - Nature Neuroscience Sun et al. report human lifespan changes in the brain’s functional connectome in 33,250 individuals, which highlights critical growth milestones and distinct maturation patterns and offers a normative...

Happy to share that our article “Human lifespan changes in the brain’s functional connectome” is now published online at Nature Neuroscience @natureneuro.bsky.social !

Many thanks to all collaborators & data contributors, and the editor team & reviewers!

www.nature.com/articles/s41...

DLPFC Stimulation Suppresses High-Frequency Neural Activity in the Human sgACC Transcranial magnetic stimulation (TMS) to the dorsolateral prefrontal cortex (DLPFC) is hypothesized to relieve symptoms of depression by inhibiting activity in the subgenual anterior cingulate corte...

When we use TMS to treat depression, we think it alters neural activity in a deep brain structure known as the subgenual anterior cingulate (sgACC). But this is hard to test directly, until our preprint with @coreykeller.bsky.social, @neuro-engineer.bsky.social, Nick Trapp, and Aaron Boes (UIowa) 1/

Study human brain structure and function with our new open access 7T MRI dataset

led by superstar scientist @donnagift.bsky.social ↙️

🚨We're hiring another tenure-track at McGill University: focus on brain-body science! 👇

mcgill.wd3.myworkdayjobs.com/en-US/mcgill...

SAVE THE DATE

2025 OHBM Oz meeting

November 12, 2025

Melbourne

We are hiring! We're looking for a Research Office to help out with recruitment & assessment on a large-scale study looking at the relationship between brain imaging measures and psychopathology. Please forward this link to anyone who might be interested:

careers.pageuppeople.com/513/ci/en/jo...

📢 Exciting news! OHBM is partnering with United Airlines for our upcoming event. Enjoy special rates on flights to Brisbane, Australia, from June 21 to July 1, 2025. For more information, visit the link in comments! #OHBM2025 #TravelwithUnited

June 2025 is an exciting month for Psychological and Brain Sciences in Australia! In addition to our joint meeting between EPC and APCV, the Organisation for Human Brain Mapping meets in Brisbane the following week. See below for a schedule of events linked with OHBM.

How is the body experienced in mental health conditions? 🧠🫀🫁

Our (@gabmackie.bsky.social) new paper in eClinicalMedicine explores lived experiences and patient priorities for interoception research. 🧵1/n

www.sciencedirect.com/science/arti...

A figure depicting responses to the question “How are body signals related to your mental health”, including both themes and example quotes. Broad themes included: (1) location of bodily sensations; (2) when sensations occur; (3) psychological symptoms and factors; (4) intensity and frequency of sensations, and (5) lifestyle factors.

Workshop contributors had a variety of initial thoughts in response to the question: “how are bodily signals related to your mental health?” This was conducted prior to any detailed information about the aims of the workshop, or the field's perceived notions of interoception. 🧵4/n

Myelinated fiber labeling and orientation mapping of the human brain with light-sheet fluorescence microscopy | bioRxiv www.biorxiv.org/content/10.1...

Getting excited about OHBM25. Not far now!
Features an AMAZING schedule of keynotes, educational workshops, symposia, networking events as well as several satellite meetings!

Don't forget to register before April 15 for the EBR!
@ohbmofficial.bsky.social

www.humanbrainmapping.org/i4a/pages/in...

Important point Andy. But volumetric data might not be as close to the real data as we think and is also based on models. E.g. we sample data on a square grid, even though the MRI point spread function is not a square.

The brain-heart connection:

Shared Pathways of Brain and Cardiovascular Health

medicalxpress.com/news/2025-02...

www.jneurosci.org/content/45/8...

Multimodal identification of the mouse brain using simultaneous Ca2+ imaging and fMRI Individual differences in neuroimaging are of interest to clinical and cognitive neuroscientists based on their potential for guiding the personalized treatment of various heterogeneous neurological c...

We've updated our mouse connectome-based ID paper using simultaneous Ca2+ imaging and fMRI connectivity data--check it out!

www.biorxiv.org/content/10.1...

Shoutout to all! @francimandi.bsky.social, @toddc.bsky.social, @mallarchak.bsky.social, @richardfbetzel.bsky.social, and many others! 1/2

Ever heard of EEG microstates? Usually defined as cluster centres of topography, the dynamics of MS sequences are referred to as "syntaxes". Our new review discusses syntax methods and show how they could be better associated with the underlying EEG signal: 🧵👇 www.sciencedirect.com/science/arti...

Topology shapes dynamics of higher-order networks - Nature Physics Higher-order interactions reveal new aspects of the interplay between topology and dynamics in complex systems. This Perspective describes the emerging field of higher-order topological dynamics and d...

Nature Physics

Topology shapes dynamics of higher-order networks
www.nature.com/articles/s41...

For data defined on top of a graph/network (e.g. annotations on brain graphs), it is efficient to decompose them with filters that adapt to the spectral characteristics of the data at hand | w. @dimitrivdv.bsky.social @rikossenkoppele.bsky.social + C-F Westin

So much research focusses on using brain connectivity to predict an individual's cognition, IQ, disease status, etc.

BUT what about the inverse problem?

Can personal data be used to build an individual's whole connectome?

YES - with AI:

www.biorxiv.org/content/10.1...

🚀 Explore Spectral Normative Modeling in action!

We’ve built an interactive visualization showcasing high-resolution normative reference ranges generated via SNM.

🔗 Try it here: sina-mansour.github.io/normative_br...

TMS is delivered to the DLPFC in depression to modulate SGC activity

But axons linking DLPFC and SGC are absent.

How then does TMS stimulation delivered to the DLPFC modulate SGC activity?

Check out Caio's work on how stimulation effects propagate in the absence of direct anatomical paths

Can damage to a specific brain circuit cause psychosis? New paper out today by @andrewpines.bsky.social @shansiddiqi.bsky.social says Yes! Hub of the circuit is in the hippocampus - great alignment with NMDA encephalitis. @braincircuits.bsky.social

Synaptome architecture shapes regional dynamics in the mouse brain | www.biorxiv.org/content/10.1...

Led by Justine Hansen

Big news: there are all sorts of different synapse types in the brain 👀‼️⤵️

Mapping Lesions That Cause Psychosis This case-control study analyzes published cases of lesion-induced psychosisTo assess whether lesions that cause secondary psychosis have functional connections to a common brain circuit

jamanetwork.com/journals/jam...
Thread below👇

9/ 🚨 But there’s more!

SNM reveals the heterogeneity in cortical atrophy among AD patients. AD patients are not only different from healthy individuals but also highly diverse among themselves, beyond the conventional findings of group/subtype-level studies.

Super excited about this new study from Sina!

Check out the schedule of events linked with OHBM 2025
- Brain connectivity workshop, June 20-22
- Hackathon, June 21-23
- Neurodesk, June 21
- Brain gradients, June 23
- Precision network therapeutics, June 29
Register now!
We look forward to welcoming you to Brisbane!
@ohbmofficial.bsky.social