David Baranger

A new favorite citation appeared!

TIL in Windows you can use PowerShell to search not only file names but also text file contents - including .R and .Rhistory files. In a moment of pure insanity, 1.5 years ago I did not save the code for a figure, but it was recorded in an old .Rhistory file!

Lol thanks!!!

Also, I will be at #SRP this week if anyone wants to chat!

Current projects in the lab include longitudinal neuroimaging of substance use at different time-scales, family-based studies of casual and genetic effects, and the development of new ML models for task fMRI. This is a funded position with up to 3 years of funding available.

Opportunities Interested in the neuroscience of addiction? We are recruiting at all levels!! Reach out to Dr. Baranger – dbaranger@mcw.edu Postdoctoral fellows/Senior Scientists: Please send an email conta…

Excited to share that I am officially recruiting a postdoc to study the neurobiology of addiction! Looking for someone who would be excited to lead current projects in the lab and develop new directions in related areas.
More info: bearlab.science/opportunities/

🧠📊 New research examines potential bias in brain age algorithms across racial groups

📈 Study of 6 popular algorithms found lower accuracy for African American participants (r=0.51-0.85) compared to White/Hispanic participants (r=0.57-0.89)/1

The lifespan trajectories of brain activities related to conflict-driven cognitive control Cognitive control is fundamental to human goal-directed behavior. Understanding its trajectory across the lifespan is crucial for optimizing cognitive…

𝐓𝐡𝐞 𝐥𝐢𝐟𝐞𝐬𝐩𝐚𝐧 𝐭𝐫𝐚𝐣𝐞𝐜𝐭𝐨𝐫𝐢𝐞𝐬 𝐨𝐟 𝐛𝐫𝐚𝐢𝐧 𝐚𝐜𝐭𝐢𝐯𝐢𝐭𝐢𝐞𝐬 𝐫𝐞𝐥𝐚𝐭𝐞𝐝 𝐭𝐨 𝐜𝐨𝐧𝐟𝐥𝐢𝐜𝐭-𝐝𝐫𝐢𝐯𝐞𝐧 𝐜𝐨𝐠𝐧𝐢𝐭𝐢𝐯𝐞 𝐜𝐨𝐧𝐭𝐫𝐨𝐥 | "The predominant lifespan trajectory is inverted U-shaped, rising from childhood to peak in young adulthood before declining in later adulthood" www.sciencedirect.com/science/arti...

Additive and Interactive Relations of Personality and Cognition With Externalizing Behaviors - Nathaniel L. Phillips, Nathan T. Carter, Kevin M. King, Courtland S. Hyatt, Max M. Owens, Donald R. Lynam... Personality and cognition offer robust frameworks to understand the individual differences associated with externalizing behaviors. However, these literatures h...

𝐀𝐝𝐝𝐢𝐭𝐢𝐯𝐞 𝐚𝐧𝐝 𝐈𝐧𝐭𝐞𝐫𝐚𝐜𝐭𝐢𝐯𝐞 𝐑𝐞𝐥𝐚𝐭𝐢𝐨𝐧𝐬𝐨𝐟 𝐏𝐞𝐫𝐬𝐨𝐧𝐚𝐥𝐢𝐭𝐲 𝐚𝐧𝐝 𝐂𝐨𝐠𝐧𝐢𝐭𝐢𝐨𝐧 𝐖𝐢𝐭𝐡𝐄𝐱𝐭𝐞𝐫𝐧𝐚𝐥𝐢𝐳𝐢𝐧𝐠 𝐁𝐞𝐡𝐚𝐯𝐢𝐨𝐫𝐬 | "Although interaction effects were detected, they were small and practically negligible in their explanation of variance in externalizing behaviors" journals.sagepub.com/doi/10.1177/...

Thanks! I was able to create an educator account on datacamp, which lets me give trainees access for free if then enroll in my 'class'. So far it looks like a useful supplement, particularly for programming concepts that might be new

Wooo NOA day! Phew.

If you're looking at pre-6.0 ABCD results with subcortical rs-fMRI correlations, the labels are all wrong! We reported a result as Auditory - L Putamen, but it it was actually Default Mode - L Cerebellum. docs.abcdstudy.org/latest/docum...

For sure. I guess my point is that a generative epistatic model with uncentered effects is equivalent to a centered model with large additive effects with the means added in after the data are generated. So the increasing additive effects you're seeing at higher MAF are expected.

Thanks so much!! Instead of saying that this is skew (MAF), I would say that this comes from not mean-centering X1/X2 before making the interaction term. I do find it surprising that the extent of the multi-collinearity (from not mean-centering) is larger when X1 & X2 are normal (MAF=0.5).

I'm finding it hard to wrap my head around this. I would have expected the opposite! Would you mind sharing your simulation code?

I posed the original as well! My re-statement is intended to explain why I'm interested in the question.

Ok thank you!!

I'm thinking of an additive effect as one in which the two variables are both significant predictors. It's not additive if one variable is unrelated, or doesn't explain unique variance. Model comparisons are also sensitive to when only one of the two is significant.

Test if two coefficients in a linear model are both significant Is there a single test one can perform that would be significant if two coefficients in a linear model are both different from 0, but would not be significant if only one of them differs from 0? Ye...

If interactions are incorrectly used when the actual hypothesis is an additive effect, then what's the appropriate test? stats.stackexchange.com/questions/66... #stats #rstats

Pitfalls in performing genome-wide association studies on ratio traits Genome-wide association studies (GWASs) are often performed on ratios composed of a numerator trait divided by a denominator trait. Examples include body mass index (BMI) and the waist-to-hip ratio, a...

But I don't know of any lit that explicitly unpacks this. Probably because they're not treated as such - main effects are mostly never included, so effects can actually be misattributed to the ratio term. See BMI - pmc.ncbi.nlm.nih.gov/articles/PMC...

IMO, ratios are often incorrectly used as a way to adjust for a baseline value. I would also be wary of using with scales that approach 0 (funky distribution). If that isn't the case, then I agree with Tom that the interpretation could be like an interaction term where you didn't mean-center first.

Folks who had RAs learn R while in your lab - what resources were helpful? Are things like datacamp worth it?

YouTube video by NPP Journal npp's "Meet the Editor" with Dr. Arpana Agrawal

Don't miss this interview with ✨new✨ @npp-journal.bsky.social Associate Editor Dr. Arpana Agrawal & our Special Projects Manager @brikchen.bsky.social

Hear Dr. Agrawal's thoughts on the scope of the journal, NPP articles, and the role of peer reviewers (aka YOU!)

www.youtube.com/watch?v=_HqN...

Beautiful! We're hoping to get over there for July 4th

Thanks!!

Thanks!! Yes, I'm super stoked to be here and connecting with great folks in the area! And thanks for the recs, the Lakefront tour is still fantastic 😁

Awesome, I'm looking forward to seeing it! And I totally hear you, better to have it out than to sit on it for years.

Oh I forgot about that, thanks! Yes totally agree that averaging across subjects could lose us some specificity. Would love to see your approach applied to the full DMCC dataset with individual difference analyses, so we can do more of an apples-to-apples comparison!

Oh for sure, and I think this approach could also be applied in a circuit-specific manner. Definitely something I plan on exploring in the future!

On the flip side, this kind of approach *does* align very nicely with approaches that involve brain-map comparisons, including things like gene expression or cross-species comparisons of whole-brain parameters, so it also depends a bit on what you mean by "cross-species"...