JCF Intersections

A HFrEF polypill💊 could ⬆️ GDMT uptake, but prescriber prefs are unknown. Using a 5-stage mixed-methods process, researchers built a discrete choice experiment to test cardiologists’ prefs—work that will directly inform future HFrEF polypill clinical trials.

🔗 https://bit.ly/3ZmjsLp

New science 🚨!

In an analysis of centrifugal-flow LVAD trials, digoxin💊 users showed greater improvement in 6MWT 🚶 vs no digoxin (especially in older pts) with similar QOL & AE rates. Digoxin was also linked to better 4-yr survival in NICM pts.

🔗 https://bit.ly/4r5phsy

📣 Last chance to sign up for Office Hours!

Join Editor in Chief Dr. Katz and Deputy Editor Dr. Reza to answer your questions on:
✅ JCF-I's upcoming publications
✅ What they are looking for in submissions
✅ Updates on the year ahead

📆 Wednesday, January 28th
🕐 12:00PM - 1:00PM

🔗 bit.ly/3NmOKz4

The January issue of JCF-I is now available 👉 bringing forward new evidence, perspectives, and conversations in heart failure + various intersections.

Read the full issue 📖 https://www.onlinejcfi.org/current

Time is running out! Register for JCF-I Office Hours⌛

Join Editor in Chief Dr. Katz and Deputy Editor Dr. Reza to answer your questions on:
✅ JCF-I's upcoming publications
✅ What they are looking for in submissions
✅ Updates on the year ahead

bit.ly/3NmOKz4

🚨 JCF-I Office Hours

Join Editor in Chief Dr. Katz and Deputy Editor Dr. Reza to answer your questions on:
✅ JCF-I's upcoming publications
✅ What they are looking for in submissions
✅ Updates on the year ahead

📆 Wednesday, January 28th
🕐 12:00PM - 1:00PM

Register 🔗: https://bit.ly/3NmOKz4

Retrospective Review of the Safety and Effectiveness of a Low-carbohydrate Ketogenic Diet Intervention in Patients With Overweight or Obesity and Heart Failure Evidence from preclinical models and several human trials suggests a therapeutic role for ketone bodies in cardiovascular conditions, including heart failure (HF).1 In normal hearts, the primary subst...

Overall, meaningful weight loss and potential cardiac benefits.

Read more 👉 bit.ly/3Ka9yZz

🍽️ Key Highlights
- 125 overweight/obese HF patients Rx LCKD were followed for avg 2 years
- Median weight loss: 11.2 kg (p<0.01)
- No ⬇️ in EF
- Significant ⬇️ in HF 🏥 in HFpEF, numerically lower in HFrEF
- LCKD was safe, with improvements in several metabolic markers

📢 New study in JCF-I on the safety and effectiveness of a low-carbohydrate ketogenic diet LCKD for weight loss in patients with overweight/obesity and HF.

This is one of the largest real-world looks at LCKD use in HF. 🫀🍽️

See below ⬇️
bit.ly/3Ka9yZz

Right Ventricular Reserve: A Scoping Review Right ventricular reserve (RVR) describes the ability of the RV to augment cardiac output via contractile or diastolic reserve under stress, providing valuable insight into latent RV dysfunction acros...

Measuring RVR offers prognostic insight across cardiopulmonary diseases, but definitions and testing methods remain inconsistent.

🔗 Read in Journal of Cardiac Failure – Intersections: bit.ly/3Kdvsef

#HeartFailure #CardioTwitter #PulmonaryHypertension #PeoplesVentricle

How well can the right ventricle rise to the challenge? 💪💙

A new JCF-Intersections paper reviews right ventricular reserve (RVR) — the RV’s ability to boost output under stress. 🧵

Cost-effectiveness of Coronary Artery Bypass Grafting Versus Percutaneous Coronary Intervention in Severe Ischemic Cardiomyopathy With the prevalence of ischemic heart disease-induced heart failure (HF) reaching epidemic proportions, the augmentation of prognosis-modifying medical therapies with revascularization strategies has ...

Despite higher upfront costs, CABG + OMT emerged as the most cost-effective strategy —guiding smarter care decisions.

Read more: bit.ly/48oKsze

💡 CABG or PCI? A new perspective on value in ischemic cardiomyopathy.

New #JCFIntersections study on cost-effectiveness analysis comparing CABG + OMT vs PCI + OMT is here.

🔗 Read in Journal of Cardiac Failure – Intersections: bit.ly/48oKsze

#HeartFailure

Getting With the Guidelines: Improving the Quality of Hospital Care in Atrial Fibrillation and Heart Failure Atrial fibrillation (AF) is an increasingly common and comorbid condition, with up to 6.1 million individuals in the United States carrying this diagnosis.1 The prevalence of heart failure (HF) in the...

This is a call to action for hospitals, payers, and policy-makers to close the evidence-to-practice gap.

🔗 Read more: bit.ly/4hyklZR

#HeartFailure #AFib #HealthEquity #QualityImprovement #JCFIntersections #AcademicMedicine

📉 Key insights: 70% of patients discharged in AF rhythm Underuse of cardioversion, ablation, rehab Large racial disparities in AF/HF prevalence Opportunities for integrated care models.

🔍 Despite increasing evidence for rhythm control and anticoagulation in patients with AF + HF, hospital-level care often falls short of guidelines.

📢 Editorial Spotlight in JCF–Intersections:

“Getting with the Guidelines: Improving Quality of Hospital Care in Atrial Fibrillation and Heart Failure” by Drs. Ifunanyachukwu Okwuosa, Enat Arega, and Utibe Essien.

bit.ly/4hyklZR

Read more 🧵

🚀 Issue 2 is live! JCF-Intersections continues to explore how collaboration and diversity shape the future of heart failure care.

💡 Discover more: https://onlinejcfi.org/current

✨Key editorial JCF–I! “Sex Differences in Cardiogenic Shock Supported w/ VA-ECMO” Highlights:
🚺Women often present sicker + receive ECMO later
🚫Less likely to receive LV venting
⚖️Despite this, survival = comparable to men
📈Urgent need to address systemic inequities in shock care

📖 bit.ly/4hyfXKn

🧬 Editorial highlight in JCF-Intersections: barriers + opportunities for TTR genetic testing in ATTR amyloidosis ➡️ Cascade testing + counseling are critical for early diagnosis + family care.

Read here: http://bit.ly/4qqST4h

#CardioTwitter #HeartFailure #Amyloidosis

📊New study explores how 🌍Social Vulnerability Index (SVI) & Social Deprivation Index (SDI) impact HF hospitalizations.

🏥Counties with higher social vulnerability & deprivation → ⬆️ HFH rates.

SVI & SDI could help identify vulnerable populations!

🔗https://bit.ly/4omF6di

#AHA2025

ICYMI: Featured in JCF-Intersections inaugural issue:
Post-hoc AFFIRM analysis on association between AAD-based rhythm control and mortality risk in AF + HFpEF, despite improved sinus rhythm.

➡️ Calls for modern trials w/ catheter ablation + GDMT.
🔗: bit.ly/4hqDvAw
#HeartFailure #AFib #HFpEF

Females on Veno-Arterial Extracorporeal Membrane Oxygenation: A Comparative Analysis Studies comparing sex differences in the indications and outcomes in patients undergoing veno-arterial extracorporeal membrane oxygenation (VA-ECMO) for cardiogenic shock are limited.

📊 In JCF–I:

VA-ECMO in cardiogenic shock: are sex differences clinically meaningful?
👩‍⚕️ Women had:
✅ Less RRT
✅ More favorable SAVE scores
📉 But similar in-hospital mortality to men
This data may inform personalized treatment strategies in mechanical circulatory support.

🔗 bit.ly/4pydpzu

This editorial in JCF–Intersections unpacks a new meta-analysis:

▶️ High-int. CICU staffing = ↓ in-hospital mortality
▶️ Intensivist-led units performed best
▶️ Dual-trained cardiac intensivists=most comprehensive care

What makes the biggest difference in CICU survival?
Staffing. 👨‍⚕️👩‍⚕️

Thomas & Flint call for structured training, better resource allocation, & future-forward triaging systems. 🚑

🔗 bit.ly/4psSrSh
#Cardiology #CICU #CriticalCareCardiology #JCFIntersections

The Training Program as a Catalyst for Clinical Trials in Cardiac Critical Care: The DOREMI Experience Designing, enrolling in and completing randomized clinical trials in the cardiac intensive care unit (CICU) are fraught with challenges that hinder progress in advancing patient care. Low recruitment ...

✔️ Trainee-led pragmatic RCT
✔️ Embedded in fellowship training
✔️ Culture of mentorship driving research + careers

🔗 bit.ly/3KpVM4u

#CardioTwitter #HeartFailure #CriticalCare

🚨 New in JCF–Intersections!
How can we make trials in cardiogenic shock feasible & impactful?

Our latest JCF–Intersections review highlights the DOREMI experience, showing how training programs + mentorship fuel pragmatic trainee-led trials in the CICU.

Read more 👇

🫀 New in JCF–Intersections:
What’s the impact of staffing models in the CICU?

Our newest published meta-analysis shows:
High-intensity staffing reduces in-hospital & CICU mortality
The benefit is strongest in intensivist-led care

Full article: http://bit.ly/4n9GNdK

#Cardiology #CriticalCare

We are excited to bring you the first issue of JCF-Intersections, where you will find important contributions that embrace and harness the concept of intersections within medicine in their own distinct and powerful ways.

🫀 Read now: https://www.onlinejcfi.org/current

Meet the editor-in-chief and deputy editor of JCF's sister journal and find out what to expect in the inaugural issue of JCF-I. #heartfailure #jcf #jcfi #hfs... Journal of Cardiac Failure - Intersections Inaugural Issue Coming Soon!

📣 Exciting news: The inaugural issue of JCF–Intersections drops tomorrow!

Hear from Dr. Jason Katz & Dr. Nosheen Reza as they share their vision for this new platform in heart failure research & care.

🎥 https://youtu.be/njAjznbE0BY

#Cardiology #MedicalResearch #JCFIntersections