Edoardo Melilli

A good one 😂😂😂😂

Cartoon of AI

Most #AI right now be like:

5/10
A figure paints🖼️ a 1000 words!
Emerging evidence from APRIL/BAFF–axis trials underscores how central this pathway is to IgAN biology. Let’s put ORIGIN side by side with the others and see what we learn!

📖 This weekend don't miss our @kireports.bsky.social #ISNFridaySelection: The Impact of Donor and Recipient Diabetes on Patient and Graft Survival in Kidney Transplant Recipients www.kireports.org/ar...

Consistent Adherence to Physical Activity Guidelines and Digestive System Cancer Risk and Mortality This cohort study using data from 3 large US prospective cohorts assesses whether adherence to the recommended physical activity level measured in metabolic equivalent task over time is associated wit...

Maintaining a moderate level of physical activity approximately 17 MET-hours/week (ie, 5 hours of brisk walking or 2 hours of running each week) over 3 decades was sufficient to achieve optimal benefit in reducing Digestive System Cancer risk.

jamanetwork.com/journals/jam...

2025 AJKD Editors' Choice Award winning article: Genetic Characterization of Kidney Failure of Unknown Etiology in Spain: Findings From the GENSEN Study

bit.ly/3WeEZ72

#VisualAbstract

A figure showing graft survival in 818 patients who received kidney transplants and were included in the combined data for all kidneys obtained from donors after brain death and after circulatory death.

A follow-up report showed that the overall benefit of machine perfusion over cold storage in kidney graft survival remained present 10 years after transplantation. Read the full report: nej.md/4hDQNK4

#MedSky #Nephrology #Surgery

📘 “Responsible Use of Artificial Intelligence to Improve Kidney Care”
🧩 Journal of the American Society of Nephrology (JASN) – Published online November 7, 2025 @asnkidney.bsky.social
@asnpublications.bsky.social

journals.lww.com/jasn/fulltex...

🚨🧬 Registrations for the IV Bootcamp are now open! Limited to 30 spots—first come, first served. Acces the link in this thread.

The APOE4 allele, present in >20% of the population, is a significant risk marker for #Alzheimers. What if we could flip it to the protective APOE2 allele?
Encouraging results in the experimental model
www.nature.com/articles/s41...
www.nature.com/articles/s41...

Chronic kidney disease currently affects 850 million people

@mariejeansson.bsky.social discover antibody-mediated TIE2 activation prevents vascular injury and ensuing tubular injury and tubulointerstitial fibrosis in experimental chronic kidney disease: www.jci.org/articles/vie...

Late breakers that included children:
✅Setanaxib in Alport (12+)

Late breakers that did NOT include children:
🚫Atacicept in IgAN
🚫CONFIDENCE
🚫PISCES: Fish oil in Dialysis
🚫LIBERATE-D
🚫balcinrenone + dapa
🚫Obintuzumab in lupus nephritis
🚫Sibeprenlimab in IgA
🚫MIL62 in membranous
+more
#KidneyWk

Get this: Coffee suppressed atrial fibrillation!
Unexpected results for recurrence from a randomized trial in participants after cardioversion from AF
#AHA25 @jama.com
jamanetwork.com/journals/jam...

JAMA journal cover, published November 7, 2025. Editorial titled "A-E-I-O-U and Sometimes Why—Dialysis in Acute Kidney Injury" by Sushrut S. Waikar, MD, MPH. Article discusses dialysis indications for acute kidney injury.

💬 @jama.com Editorial: The LIBERATE-D trial shows conservative dialysis—guided by A-E-I-O-U indications and asking "Why"—promotes earlier kidney recovery and fewer dialysis sessions in AKI.

#KidneyWK @asnkidney.bsky.social

ja.ma/4hOkM1W

Flashback #FluorescenceFriday to some of the first light-sheet imaging we were doing. Video shows the collecting duct system of the developing kidney labeled with a pan-cytokeratin antibody. Courtesy of former talented technician Deanna Hardesty.

SGLT2 Inhibitors and Kidney Outcomes by Glomerular Filtration Rate and Albuminuria This meta-analysis examines whether estimated glomerular filtration rate or degree of albuminuria, as measured by urinary albumin to creatinine ratio, modifies the effects of sodium-glucose cotranspor...

After empa-kidney, it still wasn’t clear what to do for patients with CKD without diabetes or albuminuria. This meta-analysis suggests you use flozins. #kidneywk

jamanetwork.com/journals/jam...

@mjoseperezsaez.bsky.social eso ya creo que tu te lo sabias 😉

Now live in #ASNJASN, simultaneously published with #KidneyWk: "Immunosuppression in Older Kidney Transplant Recipients: A Randomized Controlled Trial"

Read more: kidney.pub/JASN0924

Elevated exposure to air pollutants accelerates primary glomerular disease progression ABSTRACT. Air pollution is a global problem and a major contributor to adverse health outcomes in patients of all ages. Most research has focused on the ad

Air pollution doesn’t just harm the lungs and heart — it also accelerates kidney disease.
A new @ClinKidneyJ review links exposure to fine particulate matter (PM2.5) and black carbon with faster progression of glomerular diseases.
🔗 academic.oup.com/ckj/article/...

The New England Journal of Medicine Aspirin and Anticoagulation in Chronic Coronary Syndrome A Research Summary based on Lemesle G et al. | 10.1056/NEJMoa2507532 | Published on August 31, 2025 Visual representations of the patients in the trial and the treatments they were assigned. Read the full Research Summary at NEJM.org.

In patients with chronic coronary syndrome taking oral anticoagulants, adding aspirin led to higher risks of cardiovascular events, major bleeding, and death from any cause than anticoagulation alone. Full AQUATIC trial results and Research Summary: nej.md/45AU4Wp

#MedSky #CardioSky

How mRNA Vaccines Can Help Fight Cancer Turning "cold" tumors "hot"

How do mRNA vaccines help fight cancer?
A @nature.com paper today tells the story, one with big implications, as reviewed here
erictopol.substack.com/p/how-mrna-v...

A meta-analysis of 13 studies comparing health care professionals vs generative A.I. showed the latter was more likely to be perceived as more empathetic in all but 1 study
academic.oup.com/bmb/article/...

A new Nature study found that people with cancer who received an mRNA COVID vaccine while on immunotherapy lived nearly twice as long. Median survival jumped from 20.6 to 37.3 months.

That’s not a typo. Let’s talk about how, and why, that might be. 🧵

Frailty and sarcopenia double mortality in liver transplant candidates and impair recovery. Early detection, nutritional optimization, and personalized (p)rehabilitation are essential to improve outcomes. @BirminghamBRC #TXPforAll #LiverTransplantation tinyurl.com/4u4rr689

A Long-Awaited Longevity Mystery Solved Spotlighting an essential human biologic pathway targeted by drugs in clinical trials

What does the naked mole rat’s extreme healthspan have to do with ongoing clinical trials?

open.substack.com/pub/erictopo...

Carbon Emissions From Different Dialysis Modalities: A Life Cycle Assessment As the health impacts of climate change intensify, the health care sector faces growing pressure to minimize its carbon footprint. Achieving this goal requires understanding of the carbon impact of wi...

Really interesting study. I would be curious to know what the average travel distance is for in centre hemodialysis given the 36% estimated contribution from travel to the overall carbon footprint

www.ajkd.org/article/S027...

Reserpine Substantially Lowers Blood Pressure in Patients With Refractory Hypertension: A Proof-of-Concept Study AbstractBACKGROUND. Refractory hypertension (RfHTN), a phenotype of antihypertensive treatment failure, is defined as uncontrolled automated office blood p

#weekendReads from the #EditorsChoice

Does Reserpine deserve a Relook for Resistant Hypertension?

academic.oup.com/ajh/article/...

#Free

Trends in the incidence of lung cancer in never smokers in Eastern China

"There is a significant increasing trend in LCNS incidence from 2009 through 2020, especially in women and the young population."

bmjopen.bmj.com/content/15/9...

First human transplant of kidney modified to have ‘universal’ blood type Recipient diagnosed with brain death received a type-O organ, which is compatible with all blood types.

First human transplant of kidney modified to have ‘universal’ blood type: Recipient diagnosed with brain death received a type-O organ, which is compatible with all blood types. www.nature.com/articles/d41...