Edoardo Melilli

A Long-Awaited Longevity Mystery Solved Spotlighting an essential human biologic pathway targeted by drugs in clinical trials

What does the naked mole rat’s extreme healthspan have to do with ongoing clinical trials?

open.substack.com/pub/erictopo...

Carbon Emissions From Different Dialysis Modalities: A Life Cycle Assessment As the health impacts of climate change intensify, the health care sector faces growing pressure to minimize its carbon footprint. Achieving this goal requires understanding of the carbon impact of wi...

Really interesting study. I would be curious to know what the average travel distance is for in centre hemodialysis given the 36% estimated contribution from travel to the overall carbon footprint

www.ajkd.org/article/S027...

Reserpine Substantially Lowers Blood Pressure in Patients With Refractory Hypertension: A Proof-of-Concept Study AbstractBACKGROUND. Refractory hypertension (RfHTN), a phenotype of antihypertensive treatment failure, is defined as uncontrolled automated office blood p

#weekendReads from the #EditorsChoice

Does Reserpine deserve a Relook for Resistant Hypertension?

academic.oup.com/ajh/article/...

#Free

Trends in the incidence of lung cancer in never smokers in Eastern China

"There is a significant increasing trend in LCNS incidence from 2009 through 2020, especially in women and the young population."

bmjopen.bmj.com/content/15/9...

First human transplant of kidney modified to have ‘universal’ blood type Recipient diagnosed with brain death received a type-O organ, which is compatible with all blood types.

First human transplant of kidney modified to have ‘universal’ blood type: Recipient diagnosed with brain death received a type-O organ, which is compatible with all blood types. www.nature.com/articles/d41...

Ten esta respuesta preparada para los próximos meses. La vas a necesitar...

Gracias al equipo docente, + 100 Residentes de Centros españoles y portugueses y CSL VIFOR por hacer posible la edición 18 del #EncuentroMirNefro25 en Cocentaina (Alicante) 👏
Formación práctica a través de casos clínicos de todas las áreas de la nefrología... ¡Seguimos! #FormaciónSenefro

Can genetic factors act as determinants of salt sensitivity and modify the effect of salt intake on CKD? This #ASNCJASN study of the UK Biobank investigates: kidney.pub/CJASN0793

Nos presentamos con mucha ilusión y responsabilidad a la Junta Directiva de la S.E.N. 2026-2029. Una candidatura para TODOS! Conócela y súmate si lo deseas! ⬇️⬇️⬇️
sites.google.com/view/todosso...

Our Preoccupation With Protein Intake The data on high protein diets, bars, supplements, and powders will surprise you

How much protein should you consume?
erictopol.substack.com/p/our-preocc...

Image of an email from a student asking if sources "from the late 1900s" are acceptable.

I will never recover from this student email.

📢 Prehabilitation in kidney transplant candidates shows promise in improving patient readiness. A step forward in optimizing care before surgery. Tremendous collaborative work at @hospitaldelmar.bsky.social selected by @asnkidney.bsky.social for ASN in the loop this week. 💪🏼

Figure 2 Microbiome alteration precedes kidney transplant rejection. Patients with available fecal samples prior to kidney rejection (rejection group) for propensity score matched (1:2) to patients without kidney rejection (nonrejection group). (A) Plasma creatinine levels are depicted over time. The shaded area represents the 95% CI. Red bars indicate individual rejection events over time. (B) Analysis of minimum creatinine levels before and after sampling, along with the time taken to reach the first. (C) Principal coordinates analysis (PCoA) based on Bray-Curtis dissimilarity; the squares mark the centroids of each group. P value and F value from statistical comparison by PERMANOVA. (D) Number of detected operational taxonomic units (OTUs), Shannon diversity, and Simpson evenness for the propensity score–matched cohort. (E) Differential abundance analysis for bacterial taxa...

Check out a new article by Holle et al, "Gut microbiome alterations precede graft rejection in kidney transplantation patients" from the August issue of AJT! #kidneytransplant #graftrejection 10.1016/j.ajt.2025.02.010

The US sparsentan REMS requirements have been updated and now require Q3 month liver labs instead of monthly. ir.travere.com/press-releas...

Going to add this to my lecture slides.

Long-term impacts of heatwaves on accelerated ageing - Nature Climate Change Ageing is linked to environmental factors. This study shows that although participants gradually adapted to heat over time, cumulative exposure to heatwaves had stable and adverse impacts on ageing, e...

Exposure to heat waves and accelerated biological aging
www.nature.com/articles/s41...

Important implication for dialysis patient

Fig 4 Mean change from baseline in 24 hour WI-NRS score over 12 weeks in anrikefon and placebo groups. Whiskers represent 95% confidence intervals. WI-NRS=worst itching intensity numerical rating scale

Anrikefon (previously known as HSK21542) aka difelikefalin cousin, and itching

@kidneyboy.bsky.social choice of #KidneyWk draft now in the @bmj.com

www.bmj.com/content/390/...

#NephSky #Pruritis

Continuum of Preshock to Classic Cardiogenic Shock in the Critical Care Cardiology Trials Network Registry:

Answer: #2 normotensive cardiogenic shock

It’s sneaky, easy to miss but important to identify, diagnose cause, manage and admit to ICU—not the floor tele unit

Occurs in about 12% of CS patients

Mortality 17%

www.jacc.org/doi/10.1016/...

Recently @nytimes.com created some uproar with misreporting about the noble gift of life. I am an organ donor and a proud caregiver to transplant recipients. 91,869 patients are waiting for a kidney transplant & 50% would die before transplant due to organ shortage.Learn about it:
#donationsaveslife

#OpenAccess in this month's issue! "Alloreactive adaptive Natural Killer cells in renal transplantation: potential contribution to allograft microvascular inflammation" by Alari-Pahissa et al. doi.org/10.1016/j.aj...

Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression | NEJM The need to suppress a patient’s immune system after the transplantation of allogeneic cells is associated with wide-ranging side effects. We report the outcomes of transplantation of genetically m...

An impressive leap forward in the field of transplantation. I'm eagerly awaiting a whole organ modification. @senefrologia.bsky.social @edoardomelilli.bsky.social
Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression | New England Journal of Medicine www.nejm.org/doi/full/10....

❤️

Today at #WTC2025:

A patient with type 1 diabetes underwent transplantation of genetically modified allogeneic islet cells with no immunosuppression. The results of this study support the concept of immune evasion by these modified cells. Read the Brief Report: nej.md/3TXVgwp

@ttsorg.bsky.social

YouTube video by Dr. Glaucomflecken Fanconi Syndrome

I think I'm in love

youtube.com/shorts/OJy1Q...

YouTube video by NEJM Group Human Papillomavirus and Cancer | NEJM

Clear, direct, understandable, i love it
www.youtube.com/watch?v=NukU...

FDA Approves Pegcetacoplan for C3G and IC-MPGN | Docwire News The FDA approved pegcetacoplan for treating C3 glomerulopathy (C3G) and primary immune complex membranoproliferative glomerulonephritis (IC-MPGN in patients age 12 and older.

⚠️ The FDA has approved pegcetacoplan (Empaveli) for treating C3G and IC-MPGN. #kidneydisease #nephrology #nephsky #c3g www.docwirenews.com/post/fda-app...

Dietary patterns and accelerated multimorbidity in older adults - Nature Aging In a Swedish cohort, Abbad-Gomez et al. report that diet quality is inversely associated with the rate of accumulation of total, cardiovascular and neuropsychiatric chronic diseases in older adults, s...

A Swedish cohort with long term follow-up once again highlights the link between diet and chronic diseases in older adults
www.nature.com/articles/s43...

VA by Priya John

Local study from Ottawa colleagues

Reduced dose steroids in ANCA vasculitis is safe, in @kireports.bsky.social

www.kireports.org/article/S246...

#NephSky #Vasculitis