AIN/Sandipan Shringi

IDF Diabetes Atlas 11th edition 2025: global prevalence and projections for 2050 The prevalence and the burden of chronic kidney disease (CKD) are both rising steadily around the world [1]. Much of this rise can be attributed to a major

IDF Diabetes Atlas 11th edition 2025: global prevalence and projections for 2050
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The multiple autoantibodies in anti-GBM disease Anti-glomerular basement membrane (GBM) disease has long been viewed as a prototypic, organ-specific autoimmune disease defined by autoreactivity to a sing

The multiple autoantibodies in anti-GBM disease
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Genome-wide donor–recipient non-HLA mismatch and graft loss ABSTRACT. HLA-matching between donor (D) and recipient (R) is routinely performed in kidney allocation to optimize allograft survival but explains only a m

Genome-wide donor–recipient non-HLA mismatch and graft loss
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Chronic lung diseases and kidney disease: pathophysiology and management ABSTRACT. Acute kidney injury (AKI) is a critical complication in patients with chronic lung diseases (CLD), particularly during acute exacerbations. This

Chronic lung diseases and kidney disease: pathophysiology and management
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Treatment of diabetes in patients with advanced chronic kidney disease or kidney failure ABSTRACT. Chronic kidney disease (CKD) is common in both type 1 and type 2 diabetes and complicated glycemic control due to fluctuating insulin resistance

Treatment of diabetes in patients with advanced chronic kidney disease or kidney failure
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Anti-glomerular basement membrane disease—treatment standard ABSTRACT. We review the current standards of treatment and discuss novel developments in the pathophysiology, diagnosis, outcome prediction and management

Anti-glomerular basement membrane disease—treatment standard
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Perlecan is a novel target of autoantibodies in anti-glomerular basement membrane disease ABSTRACTBackground. Anti-glomerular basement membrane (anti-GBM) disease is an autoimmune kidney disease in which autoantibodies are directed against GBM c

Perlecan is a novel target of autoantibodies in anti-glomerular basement membrane disease
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Cardioprotection from intradialytic exercise: a randomized trial ABSTRACTBackground and hypothesis. Left ventricular (LV) regional wall motion abnormalities (RWMAs) related to transient ischemic events are well documente

Cardioprotection from intradialytic exercise: a randomized trial
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Genotype–phenotype correlations and clinical outcomes of genetic TRPC6 podocytopathies ABSTRACTBackground and hypothesis. Podocytopathy associated with likely pathogenic/pathogenic variants of Transient receptor potential cation channel subfa

Genotype–phenotype correlations and clinical outcomes of genetic TRPC6 podocytopathies
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Urinary rituximab loss and rate of treatment failure in membranous nephropathy ABSTRACTBackground. Rituximab is a first-line treatment for primary membranous nephropathy, but approximately one-third of patients fail to respond. Among

Urinary rituximab loss and rate of treatment failure in membranous nephropathy
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Association between exposure to air pollution and kidney function decline ABSTRACTBackground and hypothesis. Chronic kidney disease is a major global health concern, with air pollution increasingly recognized as a key contributor

Association between exposure to air pollution and kidney function decline
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Hemodialysis removes protective metabolites and disrupts mitochondrial function ABSTRACTBackground. Metabolic analyses offer valuable insights into the biochemical changes induced by hemodialysis, yet prior studies have focused on targ

Hemodialysis removes protective metabolites and disrupts mitochondrial function
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Association of urinary LIF levels with disease prognosis and treatment response to methylprednisolone in IgA nephropathy ABSTRACTBackground. Leukemia inhibitory factor (LIF) has been implicated in the production of galactose-deficient immunoglobulin A1 (IgA1) and development

Association of urinary LIF levels with disease prognosis and treatment response to methylprednisolone in IgA nephropathy
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Cost-effectiveness of protein restricted diets in advanced CKD ABSTRACTBackground. The costs of dialysis are not sustainable everywhere, resulting in many avoidable deaths. Interventions that postpone the start of dial

Cost-effectiveness of protein restricted diets in advanced CKD
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Simultaneous initiation of finerenone and empagliflozin across the spectrum of kidney risk in the CONFIDENCE trial ABSTRACTBackground. The CONFIDENCE (COmbinatioN effect of FInerenone anD EmpaglifloziN in participants with CKD and type 2 diabetes using a UACR Endpoint)

Simultaneous initiation of finerenone and empagliflozin across the spectrum of kidney risk in the CONFIDENCE trial
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The unmet need of electrolyte supplements Electrolytes are essential for the management of various kidney pathologies, both hereditary and acquired, including rare diseases [1, 2]. In this specific

The unmet need of electrolyte supplements
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Trends in Nephrology: From reducing proteinuria with steroids to curing glomerulonephritis Glomerulonephritis (GN) is a subgroup of kidney disorders characterized by inflammation and injury at the glomerular filtration barrier manifesting as hype

Trends in Nephrology: From reducing proteinuria with steroids to curing glomerulonephritis
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Long-term risks of adverse kidney outcomes after acute kidney injury: a systematic review and meta-analysis ABSTRACTBackground. Acute kidney injury (AKI) is associated with increased risks of incidence or progression of chronic kidney disease (CKD), kidney failur

Long-term risks of adverse kidney outcomes after acute kidney injury: a systematic review and meta-analysis
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A simple test of walking speed during transplant preassessment predicts positive cardiac investigations and mortality ABSTRACTBackground. Prior to renal transplant listing, cardiovascular screening is performed to stratify the risk of cardiovascular disease (CVD). However,

A simple test of walking speed during transplant preassessment predicts positive cardiac investigations and mortality
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Foam sclerotherapy for symptomatic cysts in ADPKD, ADPLD and solitary cysts ABSTRACTBackground. This medical center migrated from alcohol to sotradecol foam sclerotherapy (SFS) because of perceived improved efficacy in managing sym

Foam sclerotherapy for symptomatic cysts in ADPKD, ADPLD and solitary cysts
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Rationale, design and baseline characteristics of REMODEL, a mechanism-of-action trial with semaglutide in people with type 2 diabetes and chronic kidney disease ABSTRACTBackground. Type 2 diabetes (T2D) is the leading cause of chronic kidney disease (CKD) and kidney failure globally. Semaglutide, a glucagon-like pe

Rationale, design and baseline characteristics of REMODEL, a mechanism-of-action trial with semaglutide in people with type 2 diabetes and chronic kidney disease
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Complement activation in secondary thrombotic microangiopathies ABSTRACT. Secondary thrombotic microangiopathies (TMAs) represent a heterogeneous group of diseases associated with a high risk of kidney failure and death

Complement activation in secondary thrombotic microangiopathies
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Self-reported non-adherence to immunosuppressive medication detected by the BAASIS predicts allograft rejections in kidney transplant recipients ABSTRACTBackground. After kidney transplantation adherence to immunosuppressive medication is crucial for graft survival and its assessment requires valid

Self-reported non-adherence to immunosuppressive medication detected by the BAASIS predicts allograft rejections in kidney transplant recipients
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The environmental and genetic architectures of ageing and CKD Comment on: Argentieri MA, Amin N, Nevado-Holgado AJ, Sproviero W, Collister JA, Keestra SM, Kuilman MM, Ginos BNR, Ghanbari M, Doherty A, Hunter DJ, Alver

The environmental and genetic architectures of ageing and CKD
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High-flux hemodialysis with polymethylmethacrylate membranes reduces soluble CD40L, a mediator of cardiovascular disease in uremia ABSTRACTBackground and hypothesis. Major adverse cardiovascular events (MACE) are the main cause of mortality in hemodialysis (HD). Soluble CD40 ligand (sC

High-flux hemodialysis with polymethylmethacrylate membranes reduces soluble CD40L, a mediator of cardiovascular disease in uremia
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Middle cerebral artery aneurysms in older women with autosomal dominant polycystic kidney disease ABSTRACTBackground. Sex and age impact on intracranial aneurysms (IAs) in patients with autosomal dominant polycystic kidney disease (ADPKD) remains unclea

Middle cerebral artery aneurysms in older women with autosomal dominant polycystic kidney disease
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CKD progression, kidney failure, and mortality among US patients with IgA nephropathy ABSTRACTBackground and Hypothesis. We assessed disease progression among patients with immunoglobulin A nephropathy (IgAN) and characterized factors associ

CKD progression, kidney failure, and mortality among US patients with IgA nephropathy
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High measured GFR as a predictor of all-cause mortality and cardiovascular disease in a prospective non-diabetic population cohort ABSTRACTBackground. High glomerular filtration rate (GFR) is generally regarded as beneficial but has been associated with cardiovascular disease (CVD) and

High measured GFR as a predictor of all-cause mortality and cardiovascular disease in a prospective non-diabetic population cohort
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A novel system to continuously estimate intradialytic blood pressure in real time ABSTRACTBackground. Intradialytic hypotension (IDH) is a common complication of haemodialysis that is associated with adverse patient outcomes. We have dev

A novel system to continuously estimate intradialytic blood pressure in real time
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Life support in hemodialysis emergencies—treatment standard ABSTRACT. Hemodialysis removes uremic toxins and excess water and sodium from the blood of patients with kidney failure. For the last 60 years, this techni

Life support in hemodialysis emergencies—treatment standard
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