Another amazing drug repurposing study from Silvia Diaz Martin Alexandre Bougdour Christopher Swale and @hakimi.bsky.social Very pleased to have supported the structural work on our favorite protein family - the kinases!
05.11.2025 18:10 — 👍 1 🔁 0 💬 0 📌 0
For sure, Macron’s troubles are partly of his own making. But there is something immensely sad about a pro-European leader and standard-bearer for the democratic centre ending up with such a political mess
08.10.2025 16:11 — 👍 72 🔁 10 💬 9 📌 3
These results are truly impressive! But I do worry that #cryoEM is moving into a phase where progress is made by optimizing parameter settings for black box programs. The devil is often in the details, and I am not sure how this could be implemented in #relion, as stated, without more info.
21.09.2025 07:42 — 👍 36 🔁 10 💬 2 📌 1
Zeus had his Hydra ⚔️, now Toxoplasma has its own.
Meet Hydra: not a monster, but a brand-new protein domain.
It multimerizes like crazy & rewrites the chromatin landscape 🧬 in Toxoplasma.
Our team and colleagues from @embl.org #Grenoble just dropped the preprint 👉
www.biorxiv.org/content/10.1...
06.09.2025 09:03 — 👍 28 🔁 11 💬 1 📌 1
We believe that maintaining MAP kinase signaling when ATP levels have been depleted, for example under hypoxic conditions, that occur under a number of cell stresses, such as cancer and atherosclerosis, would be an advantage.
20.08.2025 05:31 — 👍 0 🔁 0 💬 0 📌 0
Using radiolabeled nucleotides @PaulineJYX was able to demonstrate clearly that the beta-phosphate is transferred to p38. She then also showed that the other MAP2Ks also show this property, but that RIP2K does not.
20.08.2025 05:30 — 👍 0 🔁 0 💬 1 📌 0
While preparing the MKK6-p38 complex for structural studies (science.org/doi/10.1126/sc…) we noticed that p38 was activated by MKK6 in the presence of ADP as well as ATP
20.08.2025 05:29 — 👍 0 🔁 0 💬 1 📌 0
https://www.jbc.org/article/S0021-9258(25)02429-9/fulltext
In our new paper @asbmb.bsky.social JBC we detail our surprising discovery that the MAP2Ks can use ADP to phosphorylate their substrate MAPKs – driven by @paulineJYX @ErikaPellegri13 and @jvonvelsen
t.co/spLZbaz5Wk
20.08.2025 05:28 — 👍 5 🔁 2 💬 1 📌 0
A visual with blue and green colours with a text saying "World Malaria Day".
A visual with blue and green background with a image on the left showing red lights. Bellow the image is shown a photo of a man. On the right a text about malaria and EMBL is presented.
A visual with blue and green background with a image on the bottom showing a hand with gloves golding a glass system. In the middle of the image is shown a photo of a woman. At the top a text about malaria and EMBL is presented.
A visual with blue and green background saying in the middle "Check out more in EMBL news using #malaria".
1/ Today is #WorldMalariaDay.
At EMBL, we join the global efforts to control malaria with innovative biological approaches.
👉 Swipe through to discover how scientists at EMBL study the malaria parasite and drive progress in global health.
🔗 Read more: www.embl.org/news/tag/mal...
25.04.2025 08:58 — 👍 12 🔁 3 💬 1 📌 1
We are very happy. The Editors of Journal of Applied Crystallography have chosen figures from our article (journals.iucr.org/j/issues/202...) to feature as the cover image for the February 2025 issue. THANKS
04.02.2025 21:19 — 👍 5 🔁 1 💬 0 📌 0
RIP Sine. She hired me as beamline scientist on ID14 @esrfsynchrotron 17 years ago and was a great director putting automation to the fore ultimately leading to @ID30_MASSIF1
04.01.2025 21:47 — 👍 4 🔁 0 💬 0 📌 0
EMBL scientists discovered that dextromethorphan (DXM) may treat lung #fibrosis. 🫁
DXM is an @fda.gov-approved active ingredient in nonprescription cough syrups. This study, published in Science Translational Medicine, shows how this drug may reduce lung scars.
🧪💊 www.embl.org/news/science...
18.12.2024 19:08 — 👍 25 🔁 10 💬 0 📌 0
Download UCSF ChimeraX
ChimeraX 1.9 has been released and is available now on our website
13.12.2024 17:49 — 👍 27 🔁 8 💬 0 📌 0
📢This year marks 10 years of fully automatic data collection @esrfsynchrotron @EMBLGrenoble ! Join us on the 5th Dec to celebrate the technical developments and scientific successes of @ID30_MASSIF1 👉 esrf.fr/home/events/co…
18.11.2024 13:05 — 👍 4 🔁 1 💬 0 📌 0
ok to all synchrotron and cryoEM people out there ...a hastily put together starter pack! go.bsky.app/UThze5z
15.11.2024 21:45 — 👍 20 🔁 6 💬 3 📌 4
🇩🇿 🇫🇷 scientist @Inserm - https://iab-grenoble.fr/
👀 Host-Parasite Coevolution: The Toxoplasma Paradigm
ParaFrap deputy director - https://www.labex-parafrap.fr/en/
EMBO member - https://www.embo.org/
🌍 pan-African idealist
#epigenetics #parasites
Compte officiel d'Atmo France, le réseau des Associations agréées de surveillance de la qualité de l'air en France #air #climat #énergie #santé
CryoEM, membrane proteins and whatnot
Imaging Asgard archaea and other strange organisms @embl.org Grenoble | 🦠❄️🔬#teamtomo
embl.org/wollweber
Postdoctoral researcher studying Trypanosoma in the Siegel lab 🧬
From 🇦🇷 → 🇫🇷 → 🇩🇪
Mathieu Ferron Lab @ircm.bsky.social. Prof @umontreal.ca, Montreal, Québec. Vitamin K, bone, beta cell, ER stress and diabetes. Conseiller scientifique du CRCQ.🔬Québécois.
https://www.ircm.qc.ca/en/researchers/mathieu-ferron
Structural biologist at EMBL studying pre-mRNA splicing.
CEO Puxano/CryoEM&ProteinDesign method development at the exp. and comp. level/Open Science initiative supporter/impact entrepreneurship/ art (philosophy)
Views expressed are my own.
Structural biologist and beamline scientist at Diamond light source, Hon Prof @ University of Essex. Interested in room temperature macromolecular crystallography, serial and time resolved work - and metalloproteins.
Virologist | Influenza | Polymerases | RNA Viruses | PostDoc @HeidelbergUniversity @ChlandaLAB @Bioquant | former Institut Pasteur | Science
Our lab uses structural biology to study bacterial secretion systems and effectors. We are located in Lyon, France
Launched in 2016, Chem is a Cell Press journal that is the home for high-impact, pioneering research in all sub-disciplines of chemistry.
Cell Press partners with scientists across all disciplines to publish and share work that will inspire future directions in research. #ScienceThatInspires
The ESRF, the European Synchrotron, located in Grenoble, France, is an international research infrastructure. Its bright X-rays are used to decipher the secrets of matter. www.esrf.fr
Comedian, satirist, writer, actor
Journal of Applied Crystallography, published by the IUCr, covers a wide range of research topics in applied structural science.
https://journals.iucr.org/j/
IUCrJ is a leading open-access journal published by the IUCr.
https://journals.iucr.org/m/
Biochemist. Protein crystals grower and structural biologist.
Head of LEC, IACT (CSIC). All views my own.
Running and maintaining cryoTEMs for external service provision @EMBL Imaging Centre. Mainly SPA but also cryoET. SerialEM fan!
