Chymkowitch lab

Many thanks to the organisers, sponsors, and members of the poster award committee for this prize and the wonderful conference. The work is supported by The Research Council of Norway.
@biovitenskap.bsky.social @embo.org @uio.no

🌟 Congratulations to my PhD student Patrizia Nothnagel! 🌟
Patrizia won the "SUMO" poster award at the 2025 EMBO workshop "SUMOylation: From Discovery to Translation" in La Grande-Motte, France. Her work has paid off, and I am proud of her.

Many thanks to @biovitenskap.bsky.social and the research council of Norway for supporting this study and @igbmc.bsky.social sequencing facility for processing our samples.

IRX3 buffers the SUMOylation to promote adipogenesis and block osteogenesis. IRX3 loss boosts SUMOylation, inhibits PPARγ, and pushes cells toward bone fate, which is reversible with SUMOylation inhibition.
IRX3 is an epigenetic gatekeeper.
#Epigenetics #Adipogenesis #ObesityRisk #SUMOylation

IRX3 controls a SUMOylation-dependent differentiation switch in adipocyte precursor cells Nature Communications - Here, the authors show that IRX3 is a transcriptional master regulator of multiple histone- and chromatin-remodeling enzymes and the SUMOylation pathway in adipocyte...

I am delighted to share a publication in @natcomms.nature.com. IRX3, linked to obesity via the FTO locus, influences fat vs bone cell fate. It is the result of a wonderful collaboration between S. Dankel, G. Mellgren @unibergen.bsky.social and my lab @biovitenskap.bsky.social 🍾
👉 rdcu.be/ezA5o

Postdoctoral Research Fellow in Molecular Biology and Epigenetics (279366) | University of Oslo Job title: Postdoctoral Research Fellow in Molecular Biology and Epigenetics (279366), Employer: University of Oslo, Deadline: Thursday, May 15, 2025

We are extending the application deadline for this post-doc position! Do not miss the opportunity to join an exciting project in a dynamic and collaborative research environment. @igbmc.bsky.social @pasteur.fr @univbordeaux.bsky.social @uio.no #epigenetics #cellfate #SUMOylation @ncmbm.bsky.social

Z-DNA formation induces the totipotent-like state and primes Zscan4-dependent chromatin compartmentalization A remarkable transition during murine development is the progression from the 1-cell embryo to the 2-cell stage, accompanied by the activation of a specific set of embryonic genes, epigenome reprogram...

Totipotent-like cells in early mouse embryos reorganize their genome via Z-DNA and Zscan4-driven interactions to form a “Z compartment” first supporting ZGA and later compartmentalisation to safeguard the totipotent-like state. Chromatin plasticity at its finest!
www.biorxiv.org/content/10.1...

Thank you @alexis-verger.cpesr.fr !!
I could say the same about you 👍

For this project we collaborate with @amathelier.bsky.social @ncmbm.bsky.social

Transcriptional Regulation Of Cell Fate - Department of Biosciences We investigate the mechanisms regulating chromatin and gene expression during cellular differentiation and cell cycle progression in yeast and mammals.

www.mn.uio.no/ibv/english/...

Postdoctoral Research Fellow in Molecular Biology and Epigenetics (279366) | University of Oslo Job title: Postdoctoral Research Fellow in Molecular Biology and Epigenetics (279366), Employer: University of Oslo, Deadline: Thursday, May 15, 2025

This is a 3-year, full-time position in an international research environment.
This position is funded by the Research Council of Norway.
🗓 Start date: ASAP
📅 Deadline: May 15, 2025
Apply here: www.jobbnorge.no/en/available...

We’re Hiring!
I am seeking a Pos-doc Researcher in Molecular Biology and Epigenetics. Join our team @biovitenskap.bsky.social @uio.no to explore how SUMOylation regulates epigenetic fate, gene expression, 3D-genome and chromatin during adipogenesis, with implications for obesity and cancer research.

Multimodal epigenetic and enhancer network remodeling shape the transcriptional landscape of beige adipocytes Epigenetic regulation is a key determinant of adipocyte fate and function, conferring phenotypic plasticity to adipose tissue in response to metabolic and thermal challenges. To understand the spatiot...

This study is a very elegant characterisation of the epigenetic and transcriptional divergence between white and beige adipocytes. Very useful to those studying the epigenetic mechanisms supporting cellular reprogramming.
www.biorxiv.org/content/10.1...

A figure depicting the concept of cancer attractor states within Waddington's landscape, and how gene regulatory network dynamics influence these states. The figure shows how cancerous cells derive from those that have accidentally entered into unused attractor states that are usually unoccupied in developmental trajectories.

Genome sequencing & single-cell transcriptomics continue to produce findings that challenge the idea that #cancer is purely a genetic disease. This Essay delves into #omics data that questions the somatic mutation theory & presents alternative theories based on GRNs & tissue fields.🧪
plos.io/3DRtAEW

As TAK-981 is in clinical trial for cancer, these findings highlight the need to consider its potential metabolic effects.
Nice collaboration between my group at @uio.no @biovitenskap.bsky.social, Antoine Martinez @ucauvergne.bsky.social
#Adipogenesis #SUMOylation #Metabolism #InVivo #CancerTherapy

Pharmacological inhibition of SUMOylation with TAK-981 mimics genetic HypoSUMOylation in murine perigonadal white adipose tissue Post-translational modification by the small ubiquitin-like modifier (SUMO) is essential for cellular differentiation and homeostasis. Here, we investigate the role of SUMOylation in adipose tissue...

Our recent in vivo study reveals that inhibiting SUMOylation with TAK-981 disrupts fat accumulation, leading to impaired adipogenesis and increased immune cell infiltration in perigonadal white adipose tissue.
www.tandfonline.com/doi/full/10....

A second position will be soon advertised for molecular biologists. Stay tuned!

Postdoctoral Research Fellow in Computational Biology and Epigenetics (273869) | University of Oslo Job title: Postdoctoral Research Fellow in Computational Biology and Epigenetics (273869), Employer: University of Oslo, Deadline: Friday, February 28, 2025

Applications are welcome here: www.jobbnorge.no/en/available...

The project involves integration of ATAC-seq, ChIP-seq, CAGE and HiC experiments to reveal mechanisms that prevent epigenetic and transcriptional drifting during cellular reprogramming with a particular focus on the adipose tissue.

My group @biovitenskap.bsky.social is #hiring a Post-doc in bioinformatics and biostatistics to work on #epigenetic memory in stem cells and during cell reprogramming. The position is co-supervised by @amathelier.bsky.social from @nordicembl.bsky.social

Thanks for sharing the first of the two positions that we will propose in the next 6 months @biovitenskap.bsky.social
Stay tuned!

Thanks @amathelier.bsky.social. The start of a great adventure 😀

Funding to Research on Epigenetic memory - Department of Biosciences Pierre Chymkowitch at the University of Oslo is awarded 12 million NOK by The Norwegian Research Council, to investigate how SUMOylation influences epigenetic stability and could prevent diseases like...

As part of this initiative, two postdoctoral fellowships will soon be advertised. One focusing on Molecular and Cell Biology, and one focusing on bioinformatics and biostatistics.
Stay tuned for more updates and details about these positions!
@chymkowitchlab.bsky.social
www.mn.uio.no/ibv/english/...

Dr. Michael Hoffman - Bioinformatics in Life Science – BiLS Dr. Michael Hoffman, Chair of the Computational Biology and Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, and Associate Professor at the Department of Medical ...

Oslo skeeps.

We will host @michaelhoffman.bsky.social on Mon. Jan. 27th. Looking forward to his seminar about "Identifying transcription factor binding using open chromatin, transcriptome, and methylation data."
You can also book a time to meet him.

More info at www.mn.uio.no/bils/english...

Three more days to register and submit your abstract for the upcoming TriRhena Gene Regulation Club. #epigenetics

Single molecule approaches across the central dogma! Genomics, imaging and theory! Very excited to host the first edition of Gene regulation, one molecule at a time this July @embl.org! Great lineup and many abstract selected talks!

Instead of listing my publications, as the year draws to an end, I want to shine the spotlight on the commonplace assumption that productivity must always increase. Good research is disruptive and thinking time is central to high quality scholarship and necessary for disruptive research.

How to thank your lab mates: eight ways to show gratitude at the end of year Alongside secret Santas and seasonal parties, many laboratories develop traditions to show appreciation to colleagues — from sweets and mulled wine to quizzes and ice-skating trips.

Many workplaces have parties or team meals to celebrate the end of the working year, but some show true appreciation by cultivating group traditions. Nature asked group leaders to explain these, and how they thank colleagues for their hard work. #AcademicSky

6️⃣0️⃣ Marie Skłodowska-Curie (1867-1934) 🇵🇱🇫🇷 #womeninSTEM The most famous scientist in the world. 1st woman professor at Sorbonne, only woman to win the Nobel in 2 different fields. During WWI, she invented a mobile X-ray unit that could travel to the battlefront.

www.nobelprize.org/womenwhochan...

Congratulations, Pierre @chymkowitchlab.bsky.social. It's a fantastic news indeed!
I look forward to continuing to collaborate with you on this great project.

Bioinformaticians/data scientists: stay tuned for an upcoming postdoc position to analyze cool multi-omics data supervised by Pierre and I!