Journal of Experimental Medicine

Metzemaekers, Rinzema, & @r-stadhouders.bsky.social review how memory T cells fight infections & #cancer by retaining epigenetic “memories” that enable the rapid reactivation of inflammatory genes, and how such epigenetic mechanisms may fuel T cell dysfunction in disease rupress.org/jem/article/...

Fu et al. identify biallelic germline ASXL1 variants as the cause of a novel #InbornErrorOfImmunity, linking ASXL1 deficiency to epigenetic dysregulation, combined immune deficiency, chronic viral infections, & malignancy
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PD-1 regulates tumor-infiltrating CD8+ T cells in both a cell-intrinsic and cell-extrinsic fashion, say Kristen Pauken (@kepauken.bsky.social), Samuel Markson, Arlene Sharpe @harvardmed.bsky.social and colleagues: rupress.org/jem/article/...

#TumorImmunology

I’m excited to announce that our paper, describing early and opposing roles for neutrophils and CD4 T cells in determining #TB lesion structure, is out at @jem.org ! Huge thanks to my lab, and the Urdahl, @michael-gerner.bsky.social, and Aitchison labs who made this possible

doi.org/10.1084/jem....

🚨 New study from the lab of our Vice Director, Arlene Sharpe, led by @kepauken.bsky.social & #SamuelMarkson in @jem.org.
PD-1 regulates tumor-infiltrating CD8+ T cells in both a cell-intrinsic & a cell-extrinsic fashion🧪

Jun-Ge Shi, Hong-Bing Shu, Shu Li et al identify the type I BMP receptors ALK2 & ALK3 as critical mediators of T cell activation and activation-induced #CellDeath. The roles of ALK2/3 in these processes are interdependent & independent of their BMP ligands
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@bengern.bsky.social et al. show that the early interplay between #neutrophils & CD4 T cells is pivotal in determining #TB pathology, and that depleting neutrophils can improve outcomes even at late timepoints, which has therapeutic relevance rupress.org/jem/article/...

Scientist-philosopher & former @jem.org editor René Dubos is the focus of a new e-book from @rockefelleruniv.bsky.social. The annotated bibliography by Carol Moberg covers his ideas on health, society, ecology, and humanity, all strikingly relevant today. More here: doi.org/10.48496/r61...

Attending #Cytokines2025? Are you a grad student or an early career postdoc? Don't miss the opportunity to apply to the @jem.org Early Career Travel Award!

More here👉 hubs.la/Q03yQFLq0

Delighted to share that @jem.org is offering an Early Career Travel Award to grad students and early career (year 1-2) postdocs who are presenting their work at #Cytokines2025! Apply here 👉 hubs.la/Q03yQFLq0 and feel free to reach out if you have any questions!

Insights from Willems, Kovalchuke, and @impenslab.bsky.social: Leddy et al. (rupress.org/jem/article/...) present PathMHC, a computationally guided mass spectrometry approach that boosts the detection of pathogen immunopeptides presented on infected cells. rupress.org/jem/article/...

📢 We're now accepting applications for the JEM Early Career Travel Award, for grad students & early-career postdocs to participate in a scientific conference! This year, the award will support the attendance of #Cytokines2025 @cytokinesociety.bsky.social! Apply here 👉  rupress.org/jem/pages/ea...

Our latest work exploring the IgG response to the R21 vaccine.

McDaniel, Voss, @profkatieewer.bsky.social, Ippolito et al. examine the molecular features of the antibody response to the R21/Matrix-M #malaria #vaccine in malaria-naïve volunteers, offering insights into the basis of vaccine efficacy. rupress.org/jem/article/...

✍️💻 Participate in a complimentary Journal-Based #CME activity that consists of a full-text article that is free to read, a multiple-choice question test, and an evaluation/self-assessment. Our 17th CME Activity @mskcme.bsky.social is NOW available 👉 mskcc.cloud-cme.com/course/cours...

Targeting infection-specific peptides in immunopeptidomics studies for vaccine target discovery. New approach by Owen Leddy, Bryan D. Bryson, Forest White and colleagues @mit.edu @ragoninstitute.bsky.social: rupress.org/jem/article/...

#InfectiousDisease #HostDefense

PD-1 regulates tumor-infiltrating CD8+ T cells in both a cell-intrinsic and a cell-extrinsic fashion Pauken and Markson et al. show that when PD-1–expressing and PD-1 knockout CD8+ T cells are within the same tumor microenvironment, both cell types exhibit

Excited to announce that my final co-first author publication from my postdoctoral training with Dr. Arlene Sharpe was published in @jem.org today! Thank you to everyone involved! Check out our new findings on the importance of cell extrinsic consequences after PD1 loss!

rupress.org/jem/article-...

Fantastic new paper looking at the extrinsic effects of PD-1 loss! Check it out.

@kepauken.bsky.social, Markson, Sharpe et al. @harvardmed.bsky.social show that when PD-1–expressing and PD-1 knockout CD8+ T cells are within the same tumor microenvironment, both cell types exhibit similarly enhanced functions. rupress.org/jem/article/...

In vivo antibody diversification targeting a conserved #coronavirus epitope. New study from Usha Nair, Ziqi Feng, Madhav Akauliya, Ian A. Wilson @scripps.edu, Facundo Batista @mit.edu and colleagues: rupress.org/jem/article/...

#InfectiousDisease #HostDefense #SARSCoV2

Tumor-instructed glutamine synthesis in cancer-associated fibroblasts promotes pro-tumor macrophages, say Xiaoyun Li, Sofie Hedlund Møller, Ping-Chih Ho @unil.bsky.social and colleagues: rupress.org/jem/article/...

#TumorImmunology #Metabolism

New content is available in our journal-based #CME activities @mskcme.bsky.social: 📄 “Epitope and HLA specificity of human TCRs against Plasmodium falciparum circumsporozoite protein” (van Dijk et al. doi.org/10.1084/jem....

Begin the activity 👉 mskcc.cloud-cme.com/course/cours...

Monoallelic mutations in MMD2 cause autosomal dominant aggressive periodontitis, say Tomoyuki Iwata, Yoko Mizoguchi, Tetsuya Yoshimoto, Miyuki Tsumura, Satoshi Okada, Hideshi Kawakami, Noriyoshi Mizuno and colleagues (Hiroshima University): rupress.org/jem/article/...

#Immunodeficiency

S1PR1, an endothelial-immune influencer. Samantha Mahfoud and Timothy Padera @harvardmed.bsky.social discuss new work from Geng et al. of the Srinivasan lab (rupress.org/jem/article/...) in Insights: rupress.org/jem/article/...

#MucosalImmunology #InnateImmunity #inflammation #CardiovascularBiology

Myeloid-targeting immunotherapies overcome inhibitory barriers in immune-evasive neuroblastoma, say Marie Ménard, Hiroyuki Yoda, William Weiss ans colleagues (UCSF): rupress.org/jem/article/...

#SolidTumors #InnateImmunity #inflammation

A new workflow called PathMHC, developed by Leddy, Bryson, White et al. @mit.edu combines computational tools with targeted mass spectrometry to help find pathogen-derived antigens presented on MHCs by infected cells that could be targets for T cell priming vaccines. rupress.org/jem/article/...

🔬 From JEM's July issue (rupress.org/jem/issue/22...): Fike, @spt-gc.bsky.social et al. show that IRF7 controls spontaneous autoimmune germinal center and plasma cell checkpoints. This image shows a kidney section from 6-mo-old mice stained with periodic acid–Schiff. (doi.org/10.1084/jem....)

🧑‍🔬🎙️ When you publish with JEM, you can reach more of your community by submitting a short video! Want to promote your research in your own voice? 🎦 See our guidelines: rupress.org/jem/pages/vi...

▶️ Watch video summaries from our authors: www.youtube.com/@JExpMed

The STING pathway drives non-inflammatory #neurodegeneration in NGLY1 deficiency, say Kun Yang, Nan Yan and colleagues (UT Southwestern Medical Center): rupress.org/jem/article/...

#Neuroscience #InnateImmunity #inflammation #HumanDiseaseGenetics

Taking the STING out of neurodegenerative disease. Aman Mangalmurti and John Lukens @lukensjohnr.bsky.social discuss new study from Yang et al. (rupress.org/jem/article/...) in Insights: rupress.org/jem/article/...

#Neuroscience