Bade Uckac

Parent-of-origin effects on complex traits in up to 236,781 individuals - Nature A novel multistep strategy reveals how parent-of-origin effects shape complex traits in large-scale biobanks.

Nature research paper: Parent-of-origin effects on complex traits in up to 236,781 individuals

go.nature.com/4ox9fr5

100,000 Participants scanned ✅

We are delighted to have completed the world's largest whole body imaging project, scanning the brains, hearts, abdomens, blood vessels, bones and joints of 100,000 volunteers.

A new research from Victor Flores and colleagues worth reading! @qimrb.bsky.social

Genetic risks for Parkinson’s vary across populations. More diverse data is key to better, fairer diagnosis and care. #Parkinsons #Genetics #HealthEquity

www.mdpi.com/2073-4425/16...

Human assembloid model of the ascending neural sensory pathway - Nature A human ascending somatosensory assembloid model was developed, which integrates multiple organoids to simulate the spinothalamic pathway, demonstrating functional connectivity and responsiveness to stimuli and revealing insights into pain-related genetic mutations.

Nature research paper: Human assembloid model of the ascending neural sensory pathway

https://go.nature.com/3YsLAwn

Twenty years of genome-wide association studies The first robust association between a genetic variant and disease risk.

This powerful and unbiased way to identify links between genetic variants and biological traits has changed scientists’ understanding of complex diseases and how to treat them

https://go.nature.com/3RPTMTG

Phase I/II trial of iPS-cell-derived dopaminergic cells for Parkinson’s disease - Nature After transplantation into the brain of patients with Parkinson’s disease, allogeneic dopaminergic progenitors derived from induced pluripotent stem cells survived, produced dopamine and did not form tumours, therefore suggesting safety and potential clinical benefits for Parkinson’s disease.

Nature research paper: Phase I/II trial of iPS-cell-derived dopaminergic cells for Parkinson’s disease

https://go.nature.com/4ikgYEu

Immune checkpoint TIM-3 regulates microglia and Alzheimer’s disease - Nature The immune-checkpoint molecule TIM-3 regulates microglial homeostasis, and its microglial-specific deletion reduced cognitive impairment in a mouse model of Alzheimer’s disease.

Disabling the TIM-3 protein in brain immune cells enhances their ability to clear Alzheimer’s-related plaques, improves cognition in mice, and suggests a promising therapeutic target.

#Alzheimers #BrainHealth #Neuroinflammation #Neuroscience #NatureResearch

www.nature.com/articles/s41...

**JOB ALERT**

We are hiring two post-doctoral Research Associates with experience:

• Planning and delivering stakeholder workshops
• Knowledge of systems thinking is essential
• Experience of group model building is highly desirable

Find out more and apply - buff.ly/tgdxG8B

Deadline - 04/05/25

How the brain remembers what gave you food poisoning We've all been there: one bad oyster ruins seafood forever. Now, Princeton neuroscientists have pinpointed how the brain stores memories for these powerful food aversions in mice. The new results reve...

One bad oyster, lasting brain change 🧠 Princeton neuroscientist @czimmerman.bsky.social reveals how a bad meal creates a lasting foul food memory.

📰: pni.princeton.edu/news/2025/ho...

First map of human brain mitochondria is ‘groundbreaking’ achievement Nature - Hundreds of cubes of human brain tissue help scientists to chart the energy-making capabilities of various brain regions.

🧪 Scientists have created the first map of mitochondria throughout the entire brain

https://go.nature.com/42j9YCV

Neuroprotective mechanisms of exercise and the importance of fitness for healthy brain ageing Ageing is a scientifically fascinating and complex biological occurrence characterised by morphological and functional changes due to accumulated molecular and cellular damage impairing tissue and org...

Neuroprotective mechanisms of exercise and the importance of fitness for healthy brain ageing - The Lancet www.thelancet.com/journals/lan...

(1/3)

Young people face many transitions between their teen years and early adulthood.

These transitions can cause significant changes in diet, which could continue into adulthood.

Read - buff.ly/KX7O9cA

How much fibre is in the food you eat?

Join our scientists from the @mrcepid.bsky.social for our @cambridgefestival.bsky.social event for families.

Learn more about fibre & test out our Fortune Telling Molecules!

We’ll be at the Cambridge Academy for Science and Technology, 22 March, 11am - 4pm.

Worth appreciation, have a look 👇 @qimrb.bsky.social @breastfriends.bsky.social

x.com/qimrb_instit...

I am still fairly confident that AI isn't going to put me out of a job. I was just doing some model fitting to data where I use my brain compared to automated means and I still outperform the machine and I can also tell when the results are nonsense.
rpubs.com/ardalby/algal1

We are excited to announce a new faculty position here in Cambridge, for researchers in computational and/or theoretical biology, based jointly in Genetics and Mathematics. Come and join us! Happy to answer questions about research, teaching and working here. www.jobs.cam.ac.uk/job/50414/

Unit researchers contribute to the Food Foundation Broken Plate 2025 report - MRC Epidemiology Unit The Broken Plate Report 2025 has found that too many people in the UK do not have the finances to access healthy, quality food. The report also evidences the fact […]

(1)

The @foodfoundation.bsky.social's The Broken Plate 2025 report is out! @mrcepid.bsky.social researchers @thomasburgoine.bsky.social, @jhoenink.bsky.social, & @jeanmadams.bsky.social contributed to it, finding the gap is widening between the cost of more & less healthy foods.

buff.ly/42zECIJ

The Claus Hypothesis

I felt grateful for being present at @mrcepid.bsky.social ‘s Winter Research Day on 13th December at @churchillcol.bsky.social

Fruitful discussions and incredible presentations by this lovely academic community that I am proud to be a part of.
@ukri.org @cambridgeuni.bsky.social

Funding needed to study potential link between bushfire smoke and dementia Funding needed to study potential link between bushfire smoke and dementia QIMR Berghofer is appealing for donations from the community to help researchers conduct an Australian-first study into the potential link between bushfire smoke exposure and dementia.

@qimrb.bsky.social

www.qimrberghofer.edu.au/news-2/fundi...

Worth Reading…