HUMAN Doctoral Network

Are we born with metabolic advantages that fade over time?

Liu et al., 2025 (Aging Cell) show that human umbilical cord plasma contains metabolites linked to healthy aging.

211 candidates identified.
Several decline with age.
Some extend lifespan in C. elegans.

#Longevity #Metabolomics

Metabomeeting 2025 recap ✨

Posters, science, and great discussions in metabolomics and lipidomics. Huge well done to the team for sharing their work and representing their groups so well.

On to the next experiments and discoveries! 🔬

#metabolomics #science #metabomeeting

Can one drop of blood track exercise metabolism?🤔

A 2025 Metabolomics study suggests dried blood spots🩸 can reflect key exercise-driven shifts in glycolysis, lipid use, mitochondrial pathways, and purine metabolism, using simple self-sampling.

Curious? 🔗bit.ly/4q84mEf

#microsampling #exercise

An appreciation post to the women of the HUMAN consortium. 🎉

Nine out of 12 of our DCs are women from all over the world, and they are mentored and supported by brilliant women across the network!

Cheers to all the women and girls in STEM!🥂

Patient-centric blood sampling is moving diagnostics beyond the clinic 🧪

Capillary, at-home collection can widen access, lower burden, and support decentralized care 🌍.

Read here: 🔗https://bit.ly/4pYIwnd

#metabolomics #patientcentric #noninvasive

🧬 First Webinar of 2026!

Uncovering sex-specific vulnerabilities in cancer metabolomics — from patients to pathways with Dr. Caroline Johnson of Yale School of Public Health

🗓 06.02.26
⏰ 13:00 CET
🔗 Zoom: bit.ly/humandn_webinars

#CancerResearch #Metabolomics #Webinar #HUMAN

New study confirms that tiny dried blood samples (BμS) are a viable alternative to plasma for global metabolic profiling. The Mitra device stood out, providing comparable, and in some metrics, richer metabolic information. Big step toward less-invasive testing!

Curious? 🔗 bit.ly/4pU6Hmw

HUMANs in #Madrid for our 3rd Annual Meeting 🇪🇸✨

Three days of science, discussions, workshops, lab tours, and great company at Universidad CEU San Pablo. Huge thanks to CEMBIO and Bright Giant—and to all our DCs for sharing their latest progress!

#metabolomics

🚀 New Year, new Weeked Read!

New study shows that tiny blood volumes collected with Mitra, Capitainer, and Whatman devices can deliver richer, more stable metabolic profiles than plasma—capturing key redox biomarkers like glutathione and ergothioneine.

Curious? 🔗bit.ly/4q9cJAO

#microsampling

We wish everyone a very Merry Christmas (in several languages too 😉), and a wonderful New Year ahead! 🥂 🎆

🩸✨ Small drops, big data!

Our latest study shows how CE-MS + blood microsamples can capture detailed metabolomic profiles — without the need for full blood draws.

Curious? bit.ly/4mN9ThY

#Metabolomics #CEMS #Microsampling #BloodAnalysis

Sorry to get you all excited, but due to some scheduling issues, this webinar would have to be rescheduled. 🙇‍♀️

❗No webinar this Friday, 12.12.25❗

Don’t miss this--our final webinar for the year!🔴
The HUMAN Doctoral Network hosts Dr. Panteleimon G. Takis for a deep dive into Large-scale NMR Metabolomics.

📅 12 December 2025 | 13:00 CET
🔗 bit.ly/humandn_webinars

#webinars #nmr #metabolomics

A new study shows that adduct type can totally change MS/MS fragmentation, reshaping how we interpret spectra, build molecular networks, and train AI models.

👉 It’s time for adduct-aware metabolomics.

👉 Read more: bit.ly/46MuLRM

#MassSpec #Metabolomics #AnalyticalChemistry #Science

#Weekend Read

🔦The “dark metabolome” isn’t a myth, it’s a frontier.

New research shows most unannotated signals in metabolomics are **not just fragmentation artefacts**, but real, undiscovered molecules. 🚀

🔗bit.ly/4pSxDUD

#Metabolomics #DarkMetabolome #MassSpec

How do plants create their vast chemical diversity? 🌿

Join us and Tomáš Pluskal (IOCB Prague & MZIO) for our next HUMAN Webinar:

🔬 Decoding the Chemical Universe of Plants
🗓 14 Nov 2025 | 🕐 13:00 CET | 💻 Zoom

🔗 bit.ly/humandn_webinars

#webinars #metabolomics

🔬 Piercing the secrets of tumors:
New nanoneedle tech can “imprint” living tissue, mapping lipid changes in space & time.

It can:
✅ Distinguish healthy vs cancer tissue
✅ Predict glioma grade
✅ Track chemo response in real time

🔗bit.ly/3KqOwpd

#Nanotechnology #CancerResearch #Lipidomics

🔬 New in #MassSpectrometry and @jorainer.bsky.social's team! SpectriPy bridges R & Python for data analysis.

Breaking language barriers → more flexible & reproducible science. 🚀

🔗bit.ly/48L9yJa

#RStats #Python #Bioinformatics #OpenSource

New #HUMAN paper out! 🩸

Our partners from CEMBIO explored blood microsampling (DBS, qDBS, VAMS) for untargeted #lipidomics using high-throughput LC-MS.

Volumetric devices show plasma-like precision & recovery!

🔗bit.ly/476qWXw

What if Heisenberg had a mass spec? Would he be interested in #meth-abolomics?

This latest #Weekend Read, explores how plasma metabolomics and bioinformatics modeling can uncover the hidden biological signatures of chronic methamphetamine use.

📖 Curious? 🔗bit.ly/3InEYdS

#metabolomics

#Weekend Read

#Metabolomics annotation is hard.

And JESTR attempts to makes it easier by treating molecules & spectra as two views of the same object — and ranking candidates with joint embeddings.

Result? Big gains over some existing annotation tools!

Curious? 🔗bit.ly/4mdd4PB

Metabolites ≠ genes. 🔬
Using gene-centric pathway tools for metabolomics can mislead. In this commentary, we highlight 5 key pitfalls—from poor co-regulation to analytical gaps—and suggest ways forward, including rigorous annotation & metabolic flux analysis.

Read here: bit.ly/3I1jPpE

#weekend

Starting the new semester with a #webinar!

💡 Free + open to all:
Steroid Metabolomics and Impact on Patient Care
w/ Ravinder J. Singh (Mayo Clinic)

🗓️ 19 Sept 2025 | 13:00 CET | Zoom
🔗 bit.ly/humandn_webinars

See you all there!

Read the whole essays: 🔗https://theanalyticalscientist.com/power-list/2025/what-should-be-done-to-help-analytical-science-rise-to-prominence-as-the-keystone-of-all-good-science/

For the full 2025 Power List: 🔗https://theanalyticalscientist.com/power-list/2025/

3/3

Congratulations to Georgios Theodoridis of Aristotle University of Thessaloniki, @metabomichael.bsky.social of @www.helmholtz-munich.de and Coral Barbas of Universidad CEU San Pablo!

Of course, we’re sharing with you excerpts of what we thought was the most powerful lines from their entries.

2/3

The Analytical Scientist’s 2025 Power List dropped a few weeks ago and we’re ecstatic that ❗three ❗ of our HUMAN PIs got into the Top Ten for the topic: "What should be done to help analytical science rise to prominence as the keystone of all good science?"

1/3

Weekend Read Alert❗

In this paper, single-cell mass cytometry was used to
labelled glucose and glutamine in breast cancer cells, uncovering 40 active metabolites and revealed flux heterogeneity invisible to traditional methods!

Curious? 🔗 bit.ly/3JFQjGr

#metabolomics #singlecell #weekend

Let there be METABOlites...in Munich!

We are happy that, in collaboration with Bruker Daltonics, our lab at @www.helmholtz-munich.de welcomed the first ever installation of a timsMetabo outside of Bruker HQ!

📣 Don’t miss this upcoming webinar:
“From conventional to convenient: Blood microsampling in metabolomics”
with Michael Witting, Helmholtz Munich

🗓 September 23, 2025 | 11am ET / 4pm BST / 5pm CET
✨ Register now: buff.ly/FDFCf6e

#webinars #metabolomics

Exciting progress in computational metabolomics! The newly introduced Computational Metabolomics Reference Vocabulary (CMRV) offers a unified, community-driven language to describe tools, workflows, and data types across the field.

Curious? 🔗bit.ly/4l5VcGl

#metabolomics #weekendread