Casanova Lab

Autoantibodies neutralizing type I IFNs in 40% of patients with WNV encephalitis in seven new cohorts In 13 cohorts of individuals with WNV infection, the risk of WNV encephalitis is increased 20 to >>2,000 times by circulating auto-Abs neutralizing t

Autoantibodies neutralizing type I IFNs in 40% of patients with WNV encephalitis in seven new cohorts url: rupress.org/jhi/article/...

11/ …Square Foundation, Grandir-Fonds de solidarité pour l’enfance, SCOR Corporate Foundation for Science, @enseignementsup-recherche.gouv.fr, Battersea & Bowery Advisory Group, WE Ford, G Caillaux & General Atlantic Foundation, @anrs-mie.bsky.social, and REACTing-INSERM.

10/ …@ap-hp.bsky.social, National Center for Advancing Translational Sciences (NCATS), Fisher Center for Alzheimer’s Research Foundation, @agencerecherche.bsky.social, @frm-officiel.bsky.social, @horizoneu.bsky.social, @fondationdusouffle.bsky.social…

9/ And we extend a big thank you to our funders: @hhmi-science.bsky.social, @rockefeller.edu, St. Giles Foundation, SNF Institute for Global Infectious Disease Research, @niaidnews.bsky.social, @inserm.fr, @upcite.bsky.social‬, @institutimagine.bsky.social…

8/ We thank our co-authors @anne-puel.bsky.social, @ShenYingZhang1.bsky.social, @esibor.bsky.social and many others not on Bluesky.

Auto-Abs against type I IFNs: Strong, common, and global determinants of severe arboviral diseases Autoantibodies neutralizing antiviral type I IFNs (AAN-I-IFN) underlie a small but growing number of severe arboviral diseases. These auto-Abs are strong,

7/ Causality is certain because of the extremely high relative risks, with Odds Ratios above 100, while mechanism involves disruption of type I IFN immunity. doi.org/10.70962/jhi...

Autoantibodies neutralizing type I IFNs in 40% of patients with WNV encephalitis in seven new cohorts In 13 cohorts of individuals with WNV infection, the risk of WNV encephalitis is increased 20 to >>2,000 times by circulating auto-Abs neutralizing t

6/ We now confirm and extend these findings with a study of 7 other cohorts. Overall, auto-Abs against type I IFN account for 40% of cases of West Nile virus encephalitis. doi.org/10.70962/jhi...

Autoantibodies neutralizing type I IFNs underlie West Nile virus encephalitis in ∼40% of patients Gervais et al. show that auto-Abs neutralizing type I IFNs and pre-existing infection underlie ∼40% of cases of West Nile virus (WNV) encephalitis. Blood a

5/ In 2023 we found that 40% of cases of West Nile virus encephalitis in 6 international cohorts were due to these auto-Abs. doi.org/10.1084/jem....

The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies | PNAS Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection fatality rate (IFR) doubles with every 5 y of age from childhood onward. Cir...

4/ In 2022 we reported that the proportion was even higher, at about 20%, when considering death from COVID-19. doi.org/10.1073/pnas...

Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths Autoantibodies neutralizing type I IFNs increase in prevalence over 60 years of age and underlie about 20% of all fatal COVID-19 cases.

3/ In 2021 we showed that the proportion increased to 15% when considering auto-Abs neutralizing lower, more physiological concentrations of type I IFNs. doi.org/10.1126/scii...

Autoantibodies against type I IFNs in patients with life-threatening COVID-19 In a large immunological and genomics study of COVID-19 patients, autoantibodies to type 1 interferons correlated with outcomes.

2/ In 2020 we reported that auto-Abs neutralizing high concentrations of type I IFN underlie 10% of cases of life-threatening COVID-19 pneumonia. doi.org/10.1126/scie...

Autoantibodies neutralizing type I IFNs in 40% of patients with WNV encephalitis in seven new cohorts In 13 cohorts of individuals with WNV infection, the risk of WNV encephalitis is increased 20 to >>2,000 times by circulating auto-Abs neutralizing t

1/ Which human infectious disease is best understood in 2026? West Nile virus encephalitis, with 40% of cases attributed causally and mechanistically to auto-Abs neutralizing type I IFNs. doi.org/10.70962/jhi...

Polyclonal evolution of lymphoproliferative disorders in XLP1 We investigated tumorigenesis mechanisms through transcriptomic profiling and somatic variant analysis in tumor samples from six patients with XLP1. LPD as

A breakthrough in the study of XLP:

Polyclonal evolution of lymphoproliferative disorders in XLP1 url: rupress.org/jhi/article/...

Defects in intron recycling suppress the antiviral response via a mechanism of intronic endogenous dsRNA Defective intron recycling leads to the accumulation of intron-derived double-stranded RNA in the cytoplasm, which suppresses PKR and RNase L activation. T

Again, news about human inherited DBR1 deficiency:

Defects in intron recycling suppress the antiviral response via a mechanism of intronic endogenous dsRNA url: rupress.org/jem/article-...

Cerebral amebiasis due to Acanthamoeba sp. in a patient with complete gp91phox deficiency Rare variants in CYBB (encoding gp91phox) are responsible for chronic granulomatous disease. We report a patient affected by multiple cerebral abscesses ca

Shocking:
Cerebral amebiasis due to Acanthamoeba sp. in a patient with complete gp91phox deficiency url: rupress.org/jhi/article/...

Thank you !

Human LFA-1 governs T cell immune surveillance of the skin Human inherited integrin αL (CD11a) deficiency selectively impairs skin homing of T cells and surveillance of commensal papillomaviruses.

Deficiency in the leukocyte integrin LFA1 increases susceptibility to commensal human papillomaviruses (HPVs) by impairing T cell homing and surveillance in the skin. Learn more in #ScienceImmunology: https://scim.ag/3Mzi05P

Out now in #Science #Immunology! 👇

Join us in congratulating our EiC Jean-Laurent Casanova on his 2026 Nemmers Prize in Medical Science! @casanovalab.bsky.social discovered the genetic causes of more than 20 infections, including severe COVID pneumonia. From @feinberg.northwestern.edu 👉 news.northwestern.edu/stories/2026...

Thank you !

Unmanipulated bone marrow infusion without conditioning can rescue RECQL4−/− severe combined immunodeficiency Mutations in DNA helicase RECQL4 can cause immunodeficiency, including SCID. The T cell defects are intrinsic to the hematopoietic system and amenable to h

Technical but good paper !
Unmanipulated bone marrow infusion without conditioning can rescue RECQL4−/− severe combined immunodeficiency url: rupress.org/jhi/article/...

We're proud to announce that infectious disease pioneer Jean-Laurent Casanova, MD, PhD, of @rockefeller.edu, @institutimagine.bsky.social, @hhmi-science.bsky.social, & @casanovalab.bsky.social, is the recipient of the 2026 Mechthild Esser #NemmersPrize in Medical Science: spr.ly/6008hCUaM

Thank you Oliver !

Today, @jhumimmunity.org published its 100th paper, in only one year !! 😊

Looking at the list of previous laureates, luminaries in medical research, I am overjoyed and humbled 😊

Hematopoietic stem cell transplantation following invasive mold infection in chronic granulomatous disease: Insights from a case series and literature review Bes-Berlandier et al. describe the characteristics and clinical outcomes of chronic granulomatosis disease patients undergoing hematopoietic stem cell tran

Hematopoietic stem cell transplantation following invasive mold infection in chronic granulomatous disease: Insights from a case series and literature review url: rupress.org/jhi/article/...

😊🙏

Thanks ! Ahmad will get back to you.

Low levels of IgG2 and pneumococcal antibodies as predictors of benefit from IgG replacement in IgG subclass deficiency Wågström et al. report that poor pneumococcal antibody protection and low IgG2 levels predict the need for continuous immunoglobulin therapy in IgG subclas

Here is a little gem:

Low levels of IgG2 and pneumococcal antibodies as predictors of benefit from IgG replacement in IgG subclass deficiency url: rupress.org/jhi/article/...