Roger Paredes

Extending nirmatrelvir–ritonavir treatment beyond 5 days resulted in a nominal improvement in the frequency of viral rebound and was generally well tolerated.

i.e: proportion of randomly assigned and dosed participants with sustained nasopharyngeal SARS-CoV-2 RNA concentrations below the lower limit of quantification (2·0 log10 copies per mL) from days 15 to 44.

Extended nirmatrelvir–ritonavir treatment durations for immunocompromised patients with COVID-19 (EPIC-IC): a placebo-controlled, randomised, double-blind, phase 2 trial Nirmatrelvir–ritonavir is approved for adults with mild-to-moderate COVID-19 who are at risk of severe disease. There are little clinical data to guid…

In this placebo-controlled, randomised, double-blind, phase 2 trial we publish today in Lancet Infectious Diseases, no difference was observed between three nirmatrelvir-ritonavir treatment durations (5, 10 and 15 days) in the primary endpoint, i.e:

www.sciencedirect.com/science/arti...

New paper out: the largest and most international paper to date on clustering of #longcovid patients 🧪 @ndorms.bsky.social @ox.ac.uk
www.jclinepi.com/article/S089...

Se presenta IRIS, el nuevo instituto de referencia en investigación e innovación en salud de la UPC El 5 de junio se ha presentado el Instituto de Investigación e Innovación en Salud (IRIS) de la UPC, que da continuidad al Centro de Investigación en Ingeniería

Es presenta l'IRIS, el nou institut de referència en recerca i innovació en salut de la #UPC

✅ Integrarà 12 grups de recerca acreditats i més de 170 investigadors i investigadores, ubicats en 5 campus de l'àrea metropolitana de Barcelona.

www.lavanguardia.com/launi/202506...

One Hundred Days, Incalculable Losses Emily J Erbelding, M.D., M.P.H; One Hundred Days, Incalculable Losses, The Journal of Infectious Diseases, , jiaf317, https://doi.org/10.1093/infdis/jiaf31

One Hundred Days, Incalculable Losses

Emily Erbelding (NIAID/NIH)

"Every day brought more chaos."

Termination of training grants reflected "an intentional choice to lose a generation of scientists. Recovering from [this]... will take years and probably decades."

academic.oup.com/jid/advance-...

When will we ever learn?

Thank you Dr Yamey

I’ve always believed that parents who allow their kids (which are the most precious and beloved treasure they have) to enroll in a first ever trial are the most honorable individuals in our society. I can’t think of a greater commitment to our common good. Honor to all the Yameys in this world!

Ciència - Acord de l'OMS per a les malalties infeccioses Ciència - Acord de l'OMS per a les malalties infeccioses

🎙️ En @rutgerwalls.bsky.social, director científic de la Fundació, explica a "La primera pedra" de @rac1oficial.bsky.social l’impacte de l’acord de l’OMS per a la lluita contra les malalties infeccioses.

#SalutGlobal #Infeccions #OMS @who.int

www.rac1.cat/a-la-carta/d...

Opinion | Silicon Valley Is at an Inflection Point

www.nytimes.com/2025/05/30/o...

HHS cancels nearly $600 million Moderna contract on vaccines for flu pandemics HHS has notified Moderna that it is canceling a nearly $600 million contract for vaccines for flu strains that could trigger future pandemics.

BREAKING: In a serious blow to US pandemic flu preparedness, HHS has cancelled a contract with Moderna to test and license prototype vaccines for #H5N1 #birdflu and other potential pandemic viruses.
In a pandemic, mRNA is the fastest way to vaccine doses. www.statnews.com/2025/05/28/m...

U.S. aid helped two African countries rein in HIV. Then came Trump In Lesotho and Eswatini, treatment and prevention cutbacks are hitting pregnant women, children, and teens especially hard

Many thanks to @pulitzercenter.bsky.social for making this possible. And of course to my fabulous editor, @martinenserink.bsky.social.
www.science.org/content/arti...

Latest Covid variants and outlook for UK summer There probably will be a Covid summer wave.

Quick COVID update from me discussing latest variants and prospects for summer here.

open.substack.com/pub/christin...

Member States approve WHO Pandemic Agreement in World Health Assembly Committee, paving way for its formal adoption World Health Organization Member States, meeting today in Committee A of the World Health Assembly, approved a resolution that calls for the adoption of an historic global compact to make the world sa...

WHO Member States, meeting today in Committee A of the #WHA78, approved a resolution that calls for the adoption of a historic global compact to make the world safer from future pandemics.

Read: bit.ly/4kjM6p4

A truly historic evening at the #WHA78: the #PandemicAccord resolution was approved in Committee A with 124 in favour, 0 against and 11 abstentions.

The final step: adoption in plenary tomorrow morning.

My thanks once again to @who.int Member States for choosing to keep the world safer. 🙏

We find that the closest-inferred ancestors of SARS-CoV-1 likely circulated in western China (Yunnan, Sichuan, or Guizhou), and that of SARS-CoV-2 in Yunnan, China, or Northern Laos, overlapping with contiguous karst and cave landscapes extending through these regions.

Next week, we are hosting an international scientific workshop focused on the pathogenesis of #LongCovid at
@yalemed.bsky.social.

Please join us on May 15th to learn about what we know and what we need to investigate next to get to the root causes to accelerate therapies 👇🏼👇🏼

No one can ban a rainbow
#DEIintheSky

Retweeting again in the hopes that members of the media can use this awesome resource when they report on vaccines and calls for "new" placebo controlled trials. @statnews.com @nytimes.com @washingtonpost.com @carlzimmer.com @apoorvanyt.bsky.social

Prof Anna Goodman, UK SNAP lead, will be sharing final results at this meeting. Don’t miss out #IDSky Virtual & in person options available

“We must actively challenge policies that seek to suppress knowledge, advocate for continued access to research funding, and support journals and institutions that prioritize evidence-based, apolitical dissemination of science. “

Scientific Integrity Under Threat: The Role of the IDSA, PIDS, and SHEA Journals in an Evolving Political Landscape The landscape of scientific publishing, education, and healthcare research is facing unprecedented challenges as political decisions increasingly encroach

Proud to be part of this family. Thank you editors-in-chief

“The current climate demands that we, as scientists, educators, and healthcare professionals, remain vigilant and vocal in defending the principles of scientific integrity and global health equity.” (…)

academic.oup.com/jid/advance-...

Plasma exchange therapy for the post COVID-19 condition: a phase II, double-blind, placebo-controlled, randomized trial - Nature Communications Here, the authors report results from a clinical trial testing whether therapeutic plasma exchange (TPE) can help people with post-COVID-19 condition (PCC). While TPE had a favorable safety profile, i...

Thanks for the shout out, Didier. Here you are a couple of examples of what we do:

www.nature.com/articles/s41...

www.thelancet.com/journals/lan...

JUST IN: Harvard University has sued the Trump administration following demands that it turn over all campus reports on antisemitism and anti-Muslim bias since October 2023. cnn.it/4jNTMzL

The virus possesses a biological characteristic that is not found in nature. 2. Data shows that all COVID-19 cases stem from a single introduction into humans. This runs contrary to previous pandemics where there were multiple spillover events. 3. Wuhan is home to China’s foremost SARS research lab, which has a history of conducting gain-of-function research (gene altering and organism supercharging) at inadequate biosafety levels. 4. Wuhan Institute of Virology (WIV) researchers were sick with COVID-like symptoms in the fall of 2019, months before COVID-19 was discovered at the wet market. 5. By nearly all measures of science, if there was evidence of a natural origin it would have already surfaced. But it hasn’t.

The White House has turned COVID.gov from a public health resource into a politically charged platform promoting the lab-leak theory and attacking specific scientists and the pandemic response in general. Let’s fact check its 5 headline claims… 🧵

The open gates to Harvard are pictured. Headline reads: "Trump Officials Blame Mistake for Setting Off Confrontation With Harvard." Photo credit: Sophie Park for The New York Times.

Breaking News: Trump officials blame a mistake for setting off the tectonic confrontation with Harvard. nyti.ms/4ioHtIT

Global pandemic treaty finalized, without U.S., in ‘a victory for multilateralism’ Three years in the making, the accord aims to increase equity and avoid errors of the COVID-19 pandemic

How powerful the pandemic treaty will turn out to be depends on how seriously countries take it, says @nschwalbe.bsky.social.“This agreement definitely provides a recipe and all the ingredients for a world safer from pandemics,” she says. “Countries now need to make it happen.”
🧪 #IDsky

Couldn’t be a worse time to “pause infectious diseases”

Sex Redefined: The Idea of 2 Sexes Is Overly Simplistic Biologists now think there is a larger spectrum than just binary female and male

www.scientificamerican.com/article/sex-...