Michael Haichin

Next-gen neuroplastogen developers be like

“Approval rates significantly declined from 2022 to 2024 [...] In 2022, 74 of the 90 (82%) requests were approved, followed by 123 out of 165 (74.5%) in 2023 and 107 out of 181 (59.1%) in 2024, even though the number of overall requests remained stable.”

www.nature.com/articles/s44...

This Is Your Priest on Drugs?

One of my favorite resources & collaborative opportunities for those interested in the psychedelic field!!

Amazing work!!

3 of my papers (2 preprints) made the list! Great resource and great for scoping out all that was published last year

The Interdisciplinary Annotated Psychedelic Research Bibliography of 2024 - Psychedelic Alpha Psychedelic Alpha’s Medical Advisor, Michael Haichin, compiled a list of over 500 notable psychedelics-related publications from 2024. He then presented it to a group of researchers from varying…

📚✨ ~500 Papers. ~30 Researchers & Experts. One Annotated Psychedelics Bibliography...

Very excited to share the 2024 edition of Psychedelic Alpha's Interdisciplinary Annotated Psychedelic Research Bibliography, by @michaelhaichin.bsky.social.

psychedelicalpha.com/news/the-int...

The power of “know-cebo”: 5 Questions for data scientist Balázs Szigeti Szigeti discusses expectancy effects, unblinding, and how researchers might design better studies on psychedelics.

Got interviewed by the Microdose newsletter on the intersection of #psychedelic and #placebo research and on why psychedelic research should revisit the long forgotten Zelen design to solve the "know-cebo" problem. Enjoy!

themicrodose.substack.com/p/the-power-...

Expectancy Effects, Blinding Integrity, and Placebo Response in Psychiatric Disorders This narrative review discusses the impact of expectancy effects and functional unblinding on treatment responses in randomized clinical trials of treatments in psychiatry.

Our new review in JAMA Psychiatry: "Expectancy Effects, Failure of Blinding Integrity, and Placebo Response in Trials of Treatments for Psychiatric Disorders"

jamanetwork.com/journals/jam...

Thanks to co-first author Guil Fusetto-Veronesi; and to Samuele Cortese, David Baldwin, Matt Garner

🧵👇

Q1’25 Psychedelic Drug Development Pipeline: Bullseye Chart - Psychedelic Alpha We present the psychedelic drug development pipeline in a ‘bullseye chart’ format, as of Q1’25.

New: The Q1'25 Edition of our Psychedelic Drug Development Pipeline Bullseye Chart is now available to download.

Get an overview of psychedelic candidates by molecule type and phase of development via this handy visual.

psychedelicalpha.com/news/q125-ps...

Psychedelic mental health research is booming—but how do we keep up with rapidly evolving evidence? 🌱 Our team proposes a living evidence synthesis approach to ensure clinicians, policymakers, and the public have access to the latest, most reliable data.
🔗 www.nature.com/articles/s44...
🧪🧵

Definitely!

"When restrictive regulations on psychedelic science force aboveground scientists to rely on underground knowledge, there is, at some point, no aboveground or underground—there is only dirt." 🔥🔥🔥

TV shows 📺

- Industry

- Mr. and Mrs. Smith

- English Teacher

- 3 Body Problem

- The Vince Staples Show

Podcasts 🎧

- The Bill Simmons Podcast @billsimmons.bsky.social

- The Lowe Post (RIP) @zachlowenba.bsky.social

- The Watch

- The Rewatchables

- Six Trophies @netw3rk.bsky.social @sheaserrano.bsky.social

Movies 🍿

- Dune 2

- Rebel Ridge

- My Old Ass

- Fly Me to the Moon

- Deadpool and Wolverine

(I didn't watch many this year)

Books 📚

- Tomorrow, and Tomorrow, and Tomorrow by Gabrielle Zevin

- When We Cease to Understand the World by Benjamin Labatut

- There's Always This Year: On Basketball and Ascension by Hanif Abdurraqib

- Psychedelic Outlaws by @joannakempner.bsky.social

- Flowers for Algernon by Daniel Keyes

Albums 🎶

- GNX by Kendrick Lamar

- Bando Stone & The New World by Childish Gambino

- Rooftop Live (Arun's Roof) by Fred again..

- SOS (& Deluxe: LANA) by SZA

- Home by A Song For You

5x5 for 2024

What were your 5 favourite albums, books, movies, podcasts, and TV shows this year?

See below for mine, in no particular order.

Quote this post and tell me yours!

Opinion | As Drug Culture Becomes Mainstream, Our Language Needs To Evolve. (Gift Article) We need a new language to talk about the chemicals and plants that change our consciousness.

"Navigating this new world will require a more precise understanding of the psychoactive substances that are now part of it. Instead of attempting to sort chemical compounds into good and bad, we could pay more attention to how people use them." - @mikejay.bsky.social
www.nytimes.com/2024/12/23/o...

The enculturation problem, a book chapter by Thomas Metzinger from Philosophical Perspectives on Psychedelic Psychiatry. "It probably takes time. The damage was very, very great due to this careless application. . . . But I’m afraid that the same thing would happen again now, if LSD were used too quickly and carelessly again, outside the controlled framework. If it is used too quickly, something could be spoiled that could mature in the long run. . . . LSD is a very dangerous substance. It needs tremendously subtle application; you need a reverence for this deep effect. And one should quietly let the knowledge of the right application grow." - Albert Hofmann (1989)

Thought-provoking chapter about the integration of psychedelics into society: academic.oup.com/book/58175/c...

TL;DR 10-year trial period privately funded w/ a new type of insurance and only two doses of psilocybin per year per adult available in protected spaces following psychiatric screening.

Inside the FDA’s Psychedelics Journey: Javier Muniz, MD on Breakthroughs, Challenges, and the Future of the Field - Psychedelic Alpha In our latest Pα+ interview, our Editor Josh Hardman speaks with Javier Muniz, MD, who recently left his post as Associate Director at the FDA’s Division of Psychiatry. In that role, Muniz was at the…

I spoke with Javier Muniz, MD, who just left his role as Associate Director at FDA's Division of Psychiatry, about all things psychedelics.

psychedelicalpha.com/news/inside-...

Relmada Therapeutics Reports That Data Monitoring Committee (DMC) Assessment Indicates That the Phase 3 Reliance II Trial is Futile at its Interim Analysis and is Unlikely to Meet the Primary Efficacy... The DMC did not identify any new safety concerns Relmada to evaluate potential next steps for the REL-1017 program Relmada to continue to focus…...

In reference to this latest news about esmethadone: www.relmada.com/for-investor...
Lots of candidates trying to follow ketamine failed in early and late stage trials (e.g. rapastinel). TBD with Gate molecules.
Auvelity (bupropion+DXM) may be an exception, depending on what you make of their data.

Another NMDA antagonist for depression bites the dust…
Is it still a viable target?

I’m still mourning the discontinuation of Zebra F402s (and M402s)

Sage Journals: Discover world-class research Subscription and open access journals from Sage, the world's leading independent academic publisher.

New paper! This was a fun lil collaboration with Maastricht University in which we thought we might find evidence that ayahuasca would increase false memory in an observational study. WRONG! Ended up enhancing memory (but read 'til end for caveats)
journals.sagepub.com/doi/10.1177/...
1/8

Psychoactive-controlled ketamine for OCD study
doi.org/10.1177/0269...
"We did not assess blinding...prominent differences in dissociation scores...suggest that fentanyl 50 μg also did not provide an adequate blind...would not recommend its use (but do not have a suitable alternative to recommend)."

Sign me up

Psychoactive-controlled ketamine for OCD study
doi.org/10.1177/0269...
"We did not assess blinding...prominent differences in dissociation scores...suggest that fentanyl 50 μg also did not provide an adequate blind...would not recommend its use (but do not have a suitable alternative to recommend)."

YouTube video by Louisiana Channel "Anything that comes out of a writer is fiction." | Writer Benjamín Labatut | Louisiana Channel

Benjamin Labatut is one of the most amazing writers I’ve ever read!

If you haven’t, please check “The day we ceased to understand the world” and “Maniac”

His interviews are also mind blowing:
youtu.be/E-OFnHwuTBg?...

(PDF) Major life changes following psychedelic use: A retrospective survey among people using psychedelics naturalistically PDF | Background: Psychedelic drugs show promise in facilitating a variety of long-term psychological changes, but they may also lead to unexpected... | Find, read and cite all the research you need o...

A new preprint for my new BlueSky homies: "Major life changes following psychedelic use: A retrospective survey among people using psychedelics naturalistically"
www.researchgate.net/publication/...

I don't know who made this #psychedelics paper one but I love it so much I framed a copy for my office