Christina McBride

A Phosphopantetheinyl Transferase from Dictyobacter vulcani sp. W12 Expands the Combinatorial Biosynthetic Toolkit The value of microbial natural product pathways extends beyond the chemicals they produce, as the enzymes they encode can be harnessed as biocatalysts. Microbial type II polyketide synthases (PKSs) ar...

Preprint alert!! 🎉 Ever struggle to activate a carrier protein? Led by Kenneth Hsu (Haverford '25), the Charkoudian Lab unearthed a novel PPTase from Dictyobacter vulcani 🌋 with remarkable promiscuity (in our case, better than Sfp & AcpS)!

Grateful to be an alum of this phenomenal research team 💗

Advancing (-)-Premarineosin A as a Potent Antimalarial Therapeutic via Metabolic Engineering and Late-Stage Derivatization Despite modern preventative and curative efforts, malaria has remained a major global health crisis. In 2023 alone, malaria was responsible for an estimated 263 million cases and 597,000 deaths. To co...

New preprint 🥳 the first of my PhD! We applied metabolic engineering🦠, semi-synthesis👩‍🔬, and biocatalysis🧪 to access & improve the potency of the antimalarial natural product (-)-premarineosin A.

I'm so lucky to work with such a creative, interdisciplinary, and fun team that made this all possible!

MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration Abstract. Specialized or secondary metabolites are small molecules of biological origin, often showing potent biological activities with applications in ag

Are you working on natural products? We’ve just released version 4.0 of the MIBiG data standard and repository! It now includes 3059 biosynthetic gene clusters, thanks to the combined efforts of 288 expert contributors. A thread: (1/8) academic.oup.com/nar/advance-...