Happy 4th! 🇺🇸

2025 Midwest Metabolism Meeting Join us for 2025 Midwest Metabolism Meeting at Van Andel Institute Stay informed about exciting upcoming events and activities.

Sign up for midwest metabolism & Trimad joint meeting! Abstracts are due 9/2/25. The vast majority of talks will come from the abstracts - great opportunity for trainees! www.vai.org/event/2025-m...

MITOtalks and especially MITOchats have been playing with time travel. This week, instead of bringing the future over, we will get there faster: our speaker will tell us all about a mitochondrial progeria syndrome. Usual time and place.

Two mtDNA papers of ours in one PNAS issue:
#1 on the Y951N patient mutation of PolG, heroically spear-headed by Josefin Forslund
#2 revealing surprising dNTP imbalance & subsequent mtDNA depletion in RRM2B-deficient mice, a great collaboration with the Chabes lab
www.pnas.org/toc/pnas/122...

Retromer promotes the lysosomal turnover of mtDNA Lysosomal uptake of mtDNA controls mitochondrial quality.

Excited to share our latest paper in Science Advances! We finally dissected a new pathway for mitochondrial quality control upon mtDNA replication stress! Let’s start a short thread! 🧵

www.science.org/doi/10.1126/...

Congratulations David!

clearly warrants further investigation.

Great chance for Canadian researchers to attend a great scientific meeting in Canada!

MITOtalks this week

We watched different NBA games in the 90s 😄

A reliable and selective AMPK inhibitor - really important tool for AMPK research, congratulations to the team

It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.

Time for some mito-business. Or should we say methyl-business?? Let's ask our speaker Thomas MacVicar.
This thursday, usual time and place.

Membrane Contact Sites: Methodology, Biology & Pathology Intracellular organelles are connected through regions of close apposition known as membrane contact sites (MCS). The growing understanding of MCS’ biology and function has dramatically changed the t…

If you work on contact sites, this is the meeting:

meetings.embo.org/event/25-mem...

Role of lipids in interorganelle communication Cell homeostasis and function rely on well-orchestrated communication between different organelles. This communication is ensured by signaling pathway…

#lipids and #organelle conversations.
Happy 2025!
www.sciencedirect.com/science/arti...

This the season... for the last MITOtalk in 2024.
When translation is no longer enough to understand what is going on, our speaker will tell us what happens after.