's Avatar

@fredbarras.bsky.social

12 Followers  |  4 Following  |  3 Posts  |  Joined: 11.01.2025  |  1.3335

Latest posts by fredbarras.bsky.social on Bluesky

#MicroSky

26.06.2025 18:56 — 👍 0    🔁 0    💬 0    📌 0

bsky.app/profile/plos...

26.06.2025 17:07 — 👍 0    🔁 0    💬 0    📌 1
Overall architecture of the SmsC2B2 complex. Top left: AMP-PNP-loaded SmsC2B2 crystal structure. Top right: Close-up on the binding site of the AMP-PNP/Mg2+ showing residues surrounding the binding site of AMP-PNP. Bottom left: Cryo-EM structure of the [Fe-S]-bound SmsC2B2 complex. Bottom right: Close-up on the binding site of the [Fe-S] cluster showing the C218, C239, and C242 coordinating the [Fe-S] cluster. The cluster binding site lies in a solvent-exposed hydrophobic pocket consisting of residues P40, L216, I223, Y235, F234, and P247.

Overall architecture of the SmsC2B2 complex. Top left: AMP-PNP-loaded SmsC2B2 crystal structure. Top right: Close-up on the binding site of the AMP-PNP/Mg2+ showing residues surrounding the binding site of AMP-PNP. Bottom left: Cryo-EM structure of the [Fe-S]-bound SmsC2B2 complex. Bottom right: Close-up on the binding site of the [Fe-S] cluster showing the C218, C239, and C242 coordinating the [Fe-S] cluster. The cluster binding site lies in a solvent-exposed hydrophobic pocket consisting of residues P40, L216, I223, Y235, F234, and P247.

The minimal #IronSulfurCluster [Fe-S] biogenesis systems MIS & SMS are ancestral to modern ones. This study shows that the ancestral SMS system from M. jannaschii assembles [Fe-S] clusters via unique ATP-regulated mechanisms & uses sulfide as a #sulfur source @plosbiology.org 🧪 plos.io/46l0BoC

26.06.2025 16:38 — 👍 7    🔁 3    💬 0    📌 1
Post image 12.02.2025 15:36 — 👍 0    🔁 0    💬 0    📌 0

@fredbarras is following 4 prominent accounts