Institut Pasteur | 130 years of biomedical research

Which mosquitoes pose a risk? Species, main diseases and high-risk regions From the tiger mosquito, now well established in Europe, to endemic species in the tropics or Pacific region, these insects have colonized vast areas of the planet and play a key role in local ecosyst...

🦟 From tropical islands to urban Europe, mosquitoes are adapting - and spreading diseases. Of 3,500 species, only ~100 bite humans, but some, like Aedes albopictus, can transmit dengue, chikungunya or Zika. Understanding vector competence is key to stopping outbreaks. ↘️

YouTube video by Institut Pasteur EDUCATION Advances in Stem Cell Biology Pasteur Course - Insights from participant

🧬 Advances in Stem Cell Biology Pasteur Course

"It reminded me why I decided to be a scientist."
Marianna Paladini, 2025 participant

Curious about the next session?
📍Institut Pasteur, Paris
📅June 22 – July 3, 2026
🗣️Course in English
📩Application deadline: April 5, 2026

👉 bit.ly/416K6ZU

Neutralizing human monoclonal antibodies against hepatitis E virus The Humoral Immunology Unit has identified neutralizing antibodies that are effective against the hepatitis E virus (HEV). They could be used for prevention or treatment against HEV infection, which a...

👩‍🔬 Scientists at Institut Pasteur identified powerful monoclonal antibodies that neutralize hepatitis E virus, which affects 20 million people yearly. #HepatitisE

Medical Mycology Welcome to the fascinating world of fungi, agents of major infectious diseases!

🖥️ The MOOC “Medical Mycology” is open for registration!   
👉 bit.ly/medical-myco...
🍄 Welcome to the fascinating world of fungi, agents of major infectious diseases! Discover the taxonomy, ecology, identification of fungi, epidemiology of infectious diseases, drugs, link with HIV…Share this info!

We look forward to hosting Dr. Ludovic Deriano of Institut Pasteur @pasteur.fr next week at UCSF on August 5!

He’ll share how BRCA1/2-deficient cells adapt to DNA damage and how CRISPR screens reveal new targets for cancer therapy.

Learn more & save your spot: qbi.ucsf.edu/seminar-deri...

Mirror Life: Inside the Discussion At an international conference organized jointly by the Mirror Biology Dialogues Foundation (MBDF) with the Institut Pasteur on June 12 and 13, 2025, scientists and ethicists from around the world sha...

🔬 Scientists worldwide just concluded: "mirror life" organisms should NOT be created.

At Institut Pasteur conference, experts found these hypothetical lab organisms could evade immune systems & resist antibiotics - creating untreatable diseases.

#Bioethics

A two year post-doctoral position at the BacterialGenome Plasticity Unit starting October 1st - Research

A 2-year postdoc position in my lab, under the supervision of P-Alex Kaminski, on Z-DNA phages and the benefit given by ZTGC DNA and the replication machinery, with attempt to create a Z based minireplicon
research.pasteur.fr/en/job/a-two...

📣 I'm recruiting a postdoc researcher to join my team for a project on mosquito-specific viruses and host interactions. Peep the job description & how to apply below. Perfect for soon-to-be or recent PhD graduates in mosquito vector biology 🦟 or arbovirology 🦠
🗓️ Application deadline 31 August 2025

Une protéine humaine héritée des bactéries révèle un pan méconnu de notre immunité - Salle de presse de l'Inserm Depuis quelques années, certains scientifiques explorent les liens inattendus entre les protéines humaines impliquées dans la défense de l’organisme et certains mécanismes immunitaires bactériens. C’e...

Une protéine humaine héritée des bactéries révèle un pan méconnu de notre immunité.

Lire le communiqué : presse.inserm.fr/une-proteine...

❗ Étude intéressante sur le #CovidLong

Des particules virales du SARS-CoV-2 ont été trouvées dans le cerveau de hamsters infectés, 80 jours après la phase aigüe de l’infection.

Cette présence était liée à des signes de dépression, d'anxiété et de troubles de la mémoire.

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Long COVID: SARS-CoV-2 persists in the brainstem in the long term and deregulates neuronal activity Symptoms can persist in some SARS-CoV-2 patients several months after infection. Scientists at the Institut Pasteur have demonstrated in an animal model that SARS-CoV-2 infects the brain and persists ...

🧠 New research from Institut Pasteur reveals how Long COVID works: SARS-CoV-2 persists in the brainstem for months after infection, disrupting dopamine production and neuronal activity.
#LongCOVID

Brain Surfaces of 70 primate species

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To predict the behaviour of a primate, would you rather base your guess on a closely related species or one with a similar brain shape? We looked at brains & behaviours of 70 species, you’ll be surprised!

🧵Thread on our new preprint with @r3rt0.bsky.social , doi.org/10.1101/2025...

🦠🧍‍♀️From bacterial to human immunity.

We report in @science.org the discovery of a human homolog of SIR2 antiphage proteins that participates in the TLR pathway of animal innate immunity.
Co-led wt @enzopoirier.bsky.social by D. Bonhomme and @hugovaysset.bsky.social

www.science.org/doi/10.1126/...

Biting into ancient DNA Argentinian biologist Nicolás Rascovan sheds light on how he grew his research idea to a concrete p

More about @nrascovan.bsky.social's research at @pasteur.fr
👉 buff.ly/eEucxY2

More about EU support for researchers who would like to #ChooseEurope 👉 buff.ly/fPLLv71

A human protein inherited from bacteria reveals an overlooked aspect of human immunity What if the study of bacteria could illuminate our understanding of human immunity? In recent years, scientists have been exploring unexpected links between human proteins involved in the body’s defen...

🧬 From bacteria to humans: a new study led by @institutcurie.bsky.social, @institutpasteur.bsky.social & @inserm.fr reveals SIRal, a novel human immune protein with ancestral roots. A new path for immunotherapy?

🔗 Read: www.pasteur.fr/en/press-are...

Congratulations to Rayan Chiki, (Institut Pasteur) head of the “Sequence Bioinformatics” unit, for securing the ERC Proof of Concept 2025 for his project ENZYMINER! 👏

‪@rayan.chiki.bsky.social

#Bioinformatics

Many thanks to our HITS-SIMPLAIX Colloquium speaker
@bonomimax.bsky.social from @pasteur.fr ‪for sharing valuable insights into the world of protein structures and dynamics. His talk showcased simulations and approaches for determining accurate protein structural ensembles of biological systems.

Congratulations @cbuch.bsky.social ! 👏

Brice Bathellier, directeur de recherche au CNRS, responsable de l'équipe "Dynamique du système auditif et perception multisensorielle" à l'Institut de l'Audition.

Congratulations to Brice Bathellier, (Institut Pasteur and @cnrs.fr) head of the “Auditory System Dynamics & Multisensory Perception” team at the Hearing Institute, for securing the ERC Proof of Concept 2025 for his project BRAINCODER! 👏

@bathellierlab.bsky.social

#Neuroscience

The ClostPath conferences, which began in 1995, have been a leading venue to bring together top scientists and clinicians studying the molecular biology of clostridia and their role in health and disease. In keeping with this tradition, Clostpath 14 will cover all aspects of clostridia-dependent pathogenesis and will take place September 1 - 4, 2025. The congress will open with a welcome word by Prof. Yasmine Belkaid, President of the Institut Pasteur, followed by an introducing keynote.

🦠 ClostPath 2025 is coming to Paris! 🇫🇷
Join us Sept 1-4, 2025 at Institut Pasteur for the 14th International Conference on Molecular Biology & Pathogenesis of Clostridia.

📝 Register now: www.clostpath2025.conferences-pasteur.org/home

Mass Spectrometry Reveals Novel Features of Tubulin Polyglutamylation in the Flagellum of Trypanosoma brucei Tubulin polyglutamylation is a key feature of eukaryotic cilia and flagella that is essential for their function. The diversity of enzymes catalyzing polyglutamylation with different specificities ins...

Finally out! Mass spec analysis of #trypanosome flagellar tubulins reveals some surprises including a new #glutamylation site on beta-tubulin! Many thanks to the teams of Julia Chamot-Rooke and Mariette Matondo!
pubs.acs.org/doi/10.1021/...

YouTube video by European Commission From Ancient Bones to Modern Insights: Argentinian Scientist Uncovering History of Disease in Paris

www.youtube.com/watch?v=hMH1...

I am very thankful to the @ec.europa.eu for highlighting my research at @institutpasteur.bsky.social . It is a privilege for me to have the opportunity of developing my professional life here.

Pasteur Course: Hearing: from mechanisms to restoration technologies 📍 Institut de l’Audition – Institut Pasteur 📅 October 20–31, 2025 🗣️ Course in English ⌛Registration deadline: July 15, 2025

🚨 Only 1 week left to apply! Hearing: from mechanisms to restoration technologies 🎧

Final call for this advanced Pasteur Course on hearing science and auditory restoration.

🎯For Master’s students, PhD candidates, clinicians & hearing professionals.

Apply now 👉 bit.ly/HearingCourse

Une chaise vide illustre la menace sur la recherche

PLF 2026 : les hypothèses étudiées risquent de réduire fortement les dons aux
fondations de recherche.
À l’Institut Pasteur, 1/3 de nos ressources dépendent des dons.
Affaiblir cette générosité, c’est menacer notre capacité à innover et à protéger la santé
de tous.
www.pasteur.fr/fr/espace-pr...

"Chairs of Excellence in Biology/Health": two new Institut Pasteur laureates The Institut Pasteur is delighted that two of the winners of the new "Chairs of Excellence in Biology/Health" call for proposals round launched by the French National Research Agency (ANR) are its own...

🏆 Congratulations to Simonetta Gribaldo @sgribaldo.bsky.social and Marc Lecuit @biupasteur.bsky.social !
Our two researchers have been awarded prestigious ANR Chairs of Excellence in Biology/Health for their innovative projects.

Finally out, our paper on natural language processing for epidemiology:
www.nature.com/articles/s41...

We show how large language models can help determine circumstances of pathogen transmission by extracting epidemiologically relevant information from free text.
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A new study delivers the most comprehensive phylogenomic analysis of Spirochaetes to date, revealing their deep evolutionary roots and shedding light on the loss of spiral morphology and host adaptation.
✍️ @microbiomol.bsky.social and coll. @pasteur.fr
📖 shorturl.at/UxAWu
#MicroSky

Beautiful cartoons on the grids of the Institute illustrating our future research centre on vector-borne diseases @pasteur.fr with lovely #trypanosomes and a tsetse fly 😉
Many thanks to Céleste Gangolphe for the exceptional work!

Jean-Baptiste Masson ©Institut Pasteur

👏 Félicitations à Jean-Baptiste Masson !
Notre chercheur a été nommé Ambassadeur IA santé par la Ministre Clara Chappaz dans le cadre du plan "Osez l'IA" pour accélérer l'adoption de l'intelligence artificielle dans l'économie. @info.gouv.fr #IA #SantéNumérique

In-host evolution of Yersinia enterocolitica during a chronic human infection - Nature Communications This study documents the evolution of antibiotic resistance and major growth defects in Yersinia enterocolitica in a patient over 14 years, revealing genetic changes that shed light on bacterial adapt...

1/8 - New in @natcomms.nature.com !
☣️ Meet Yersinia enterocolitica (Ye) — a lesser-known but still dangerous cousin of Yersinia pestis.
We uncover how this invasive pathogen can survive and adapt for 14 years inside a human host under constant antibiotic pressure 👇
www.nature.com/articles/s41...