Steve Goldup

Research Associate positions in Computational Chemistry, AI in Chemistry, and in Neurosymbolic Learning for Chemistry at Imperial College London An opportunity for an academic position as a Research Associate positions in Computational Chemistry, AI in Chemistry, and in Neurosymbolic Learning for Chemistry is available, as advertised on jobs.a...

🚨 Three PDRA posts @imperialchemistry.bsky.social with me + collaborators to transform materials discovery.

Focus:
💻 Comp Chem
🤖 AI in Chem
🧠 Neurosymbolic Learning

🗓️ Apply by 11 Nov 2025
🔗 jobs.ac.uk/job/DPB378 (click "Apply" to find individual post details)

#chemsky #compchem #chempostdoc

Early Career Research (ECR) Group Leader position (m/f/d) with the thematic focus on “Catalysis” within the Cluster of Excellence RESOLV

Please check this announcement for an early-career group leader, hosted jointly by our cluster of excellence RESOLV and the MPI Kofo. The thematic focus should be on catalysis: jobs.ruhr-uni-bochum.de/jobposting/4...

Promotional image for symposium with background image targeting a cell and the RSC logo. Text on image states: Chemical Science Symposium, 18-19 November 2026, London UK. Register by 20 October 2025.

This year's Chemical Science Symposium celebrates the chemistry of imaging, biosensing and diagnostics. Join us to explore cutting edge research from our international speakers and the 2025 Chemical Science Lectureship winner.

18-19 November 2025
London, UK, and online

www.rsc.org/events/d...

Coordination sphere interactions drive isomer selection in heteroleptic Pd(II) cages with low-symmetry ligands The targeted formation of low-symmetry coordination cages represents a significant design challenge but offers the potential to engineer bespoke molecular hosts with precision. In this work, we have c...

Congratulations to Paulina who has just published her first first author paper from her PhD doi.org/10.1039/D5SC... and her #MyFirstChemSci @chemicalscience.rsc.org looking at coordination sphere interactions driving isomer selectivity in heteroleptic cages with low-symmetry ligands

Wow. Just when you thought he couldn't get more crass... Or generally horrific.

Congratulations Kim! 🎉🎉🎉

Our symposium on #ML for #materials at #IMRC2025 went great - big thanks to my fellow co-organisers Huziel Sauceda and @gabrielmerino.bsky.social, and 👏🏻 to the amazing speakers Claudia Draxl, Alex Tkatchenko, Qian Yang, Valentin Vassilev-Galindo, and others. Proud to reach gender parity in talks!

From @cornellab.bsky.social‬, the first example of an organobismuth(iii) dihydride (@jacs.acspublications.org).

The compound was shown to be thermally unstable, decomposing to form a bismuth(i) species and H2.

🔗 CSD Entry LAMGAM: dx.doi.org/10.5517/ccdc...

#FeaturedStructureFriday #CompChemSky

Become my colleague!!! We are recruiting in a junior faculty level. Junior Professor for Theoretical Chemistry of Macromolecular and Supramolecular Systems
#simulations #theory #noneqsys #assistantprofessor #chemjob
Thank you for sharing this.

berufungsportal.uni-mainz.de/ausschreibun...

vMASC Call to volunteer for the vMASC committee vMASC: Expression of interest to volunteer for the vMASC committee The organising committee of the virtual Macrocyclic and Supramolecular Chemistry We are inviting members of the vMASC community to…

📣 Call for Volunteers - vMASC 📣

Submit your expression of interest to join the vMASC organising committee!

Deadline 📆 18th Aug 2025

Eligibility: full-time researcher (including early career) + member of RSC MASC Interest Group

Find out more on mascgroup.co.uk/vmasc-4/vmas...

2025 MASC Prize Calls MASC: The Macrocyclic and Supramolecular Chemistry Interest Group 2025 MASC Prize Calls 2025 RSC MASC Group PhD Thesis Award given in memory of John Fossey: The RSC MASC Group P…

The 2025 MASC Group Awards are all open for nominations, with the following deadlines:

🏆 MASC Group Supramolecular Chemistry Award. 📆 5th Sep

🏆 Bob Hay Award Lectureship. 📆 5th Sep

🏆 MASC Group PhD Thesis Award. 📆 7th Nov

🏆 MASC/WISC EDIA Award. 📆 5th Sep

More on mascgroup.co.uk/2025-masc-pr...

This illustration shows consecutive stages during operation of a molecular catenating machine.

This week in Science, researchers report an artificial molecular motor that can twist a molecular thread to form a mechanically interlocked molecule. The approach creates opportunities to fabricate mechanically interlocked molecules with precise structural control.

Learn more: scim.ag/40FboGP

A group of people posing for a photo in a lecture theatre

It has been a fantastic #ECRMASC25! Thanks to the Langton group for organising, and to all the attendees for making it a memorable and inspiring day!
#RSC_MASC

Engineering antisense oligonucleotides for targeted mRNA degradation through lysosomal trafficking Antisense oligonucleotides (ASOs) can modulate gene expression at the mRNA level, providing the ability to tackle conventionally undruggable targets and usher in an era of personalized medicine. A key mode of action for ASOs relies upon RNase H-engagement in the nucleus, however, most mature mRNA is present in the

Exciting new research in Chemical Science from @drmikebooth.bsky.social and co-workers at the University of Oxford and University College London!

"Engineering antisense oligonucleotides for targeted mRNA degradation through lysosomal trafficking"

Free to read:
doi.org/10.1039/D5SC...

Researcher presenting using PowerPoint slides in a lecture theatre

A privilege to have Prof. Rachel O’Reilly FRS from the university of Birmingham as a plenary speaker at this year’s #ECRMASC25!
#RSC_MASC

Willy Wonka Chocolate Factory GIF ALT: Willy Wonka Chocolate Factory GIF

Here’s a thread rolling up all of the Drug Discovery Axioms. May add a few more in the future.

This was all made possible by the hard work of *lots* of outstanding & creative scientists, support from the
@royalsociety.org, EPSRC @ukri.org, @leverhulmetrust.bsky.social & @erc.europa.eu, some luck & my family putting up with me babbling about symmetry at inopportune moments - thank you all!

The End of the Beginning of Mechanical Stereochemistry ConspectusStereochemistry has played a key role in the development of synthetic chemistry for the simple reason that the function and properties of most molecules, from medicine to materials science, depend on their shape and thus the stereoisomer used. However, despite the potential for rotaxanes and catenanes to display unusual forms of stereochemistry being identified as early as 1961, this aspect of the mechanical bond remained underexplored and underexploited; until 2014 it was only possible to access chiral rotaxanes and catenanes whose stereoisomerism is solely attributable to the mechanical bond using chiral stationary phase high performance liquid chromatography, which limited their production on scale and thus inhibited the investigation of their properties and applications. Furthermore, the stereogenic units of such molecules and analogues were often poorly described, which made it hard to fully articulate both what had been achieved in the field and what problems were left to solve. Relatively recently, methods to access rotaxanes and catenanes that display mechanical stereochemistry selectively have been developed, making these intriguing structures available for study in a range of prototypical applications including catalysis, sensing, and as chiral luminophores.In this Account, we briefly discuss the history of mechanical stereochemistry, beginning in 1961 when the potential for mechanical stereoisomerism was first identified, before defining how mechanical stereochemistry arises from a structural point of view. Building on this, using simple stereochemical arguments, we confirm that the complete set of unique stereogenic units of two-component rotaxanes and catenanes have finally been identified and categorized unambiguously, with the last being identified only in 2024. After pausing to discuss some of the stereochemical curiosities that arise when molecules contain both covalent and mechanical stereogenic units, and the potential for stereoisomerism to arise due to co-conformational movement, we use our stereochemical framework to summarize our efforts to develop conceptually general approaches to [2]catenanes and [2]rotaxanes containing all of the possible mechanical stereogenic units. In particular, we highlight how the nature of a mechanical stereogenic unit affects the available strategies for their stereoselective synthesis. We finish by highlighting recent prototypical chemical applications of interlocked molecules that rely on their mechanical stereochemistry, before discussing future directions and challenges.Taken together, we propose that the transition of such molecules from being hard to make and poorly described, to being available in high stereopurity using clearly articulated methodological and stereochemical concepts suggests that the field is finally maturing. Thus, we are now coming to the end of the beginning of mechanical stereochemistry. The stage is now set for such molecules to play a functional role in a range of areas, indeed in any chemical or physical application where control over molecular shape is required.

This led us to declare “the end of the beginning” of mechanical stereochemistry in 2024 (doi.org/10.1021/acs....) - we can now make them efficiently, describe them accurately and are starting see what they are useful for! In some ways the Corday-Morgan marks the end of an era🥹

We have since made rotaxanes & catenanes stereoselectively (doi.org/10.1016/j.ch...), found new stereochemistry (doi.org/10.1038/s415...) & redefined mechanical stereochemistry theory (doi.org/10.1038/s415...). We even made a mechanically chiral catalyst (doi.org/10.1016/j.ch...

An Efficient Approach to Mechanically Planar Chiral Rotaxanes We describe the first method for production of mechanically planar chiral rotaxanes in excellent enantiopurity without the use of chiral separation techniques and, for the first time, unambiguously as...

I say 10 years because Rob Bordoli’s synthesis of chiral rotaxanes appeared in 2014 (dx.doi.org/10.1021/ja41...), although seeds were planted in 2011 by Hicham Lahlali when he saw an unexpectedly complicated 1H NMR spectrum (doi.org/10.1002/anie...) - always watch for weird data 😜

Honored to receive the #RSCPrizes Corday-Morgan Mid-Career Prize for Chemistry. Credit has to go to the hard work and creativity of many outstanding researchers over 10 years at 3 institutions (@qmul.bsky.social, @unisouthampton.bsky.social, @unibirmingham.bsky.social). Short🧵

Thanks Anna! That's a very impressive list to be included in!

Always a joy to see awesome people win #RSCPrizes! Huge congratulations to everyone, including @drschniff.bsky.social @jelfschem.bsky.social @profdjadams.bsky.social @sgoldup.bsky.social @donnablack.bsky.social @rebeccamelen.bsky.social & more 🥳🥳🥳

Congratulations! Excellent news on a Friday night

Full Professor. Pretty cool milestone. Thanks to my family, research team, collaborators, mentors, and colleagues. I am eternally grateful.

There is a predoctoral position available in my group. Details here (www.polymat.eu/uploads/open...) and below.

Chemists recognised in King’s birthday honours Royal Society of Chemistry hails chemists recognised for their research and inclusion and diversity work

Several people have been recognised in the King’s 2025 birthday honours for their contributions to chemistry, including Rachel O’Reilly, Kevin Coutinho, Julie Fitzpatrick, Vernon Gibson, @chionwurah.bsky.social and Stephen Foots. #ChemSky

I would say I'll race you but I'm pretty sure I'm meant to be on the plane by now! Hopefully not too delayed - looking forward to lots of exciting science!