Gabriele Zaffagnini

Looking forward to!

The #cellbio2025 is starting this week! I’ll be giving a talk on the first 1st day, in the session organized by @iaincheeseman.bsky.social and @abbybuch.bsky.social (Thx for the invitation!). If you’re interested in #oocytes, #proteostasis, and #aging come by to attend! @ascbiology.bsky.social

Thank you! 🙏🏻

Happy Sunday egg-ficionados! Here comes the latest issue of #cebooc, full of Christmas atmosphere and great papers!

biomed.news/bims-cebooc/...

Highlight: pubmed.ncbi.nlm.nih.gov/41308649/ by @yanivelkouby.bsky.social

Thanks @biomednews.bsky.social for preselecting!

Ho ho ho, happy Sunday egg-ficionados! Here is another great issue of #cebooc: biomed.news/bims-cebooc/...

Highlight: pubmed.ncbi.nlm.nih.gov/41241715/
Runner-up: pubmed.ncbi.nlm.nih.gov/41271398/

Thanks @biomednews.bsky.social for preselecting!

It's Sunday again and a new issue of #cebooc is out!
biomed.news/bims-cebooc/...

Highlight: pubmed.ncbi.nlm.nih.gov/41223274/ on the maternal #mitochondria selection

Runner-up: pubmed.ncbi.nlm.nih.gov/41210958/

Thanks @biomednews.bsky.social for preselecting!

After leaving Italy I always thought that the best thing Europe could do for its future stability would be establish a mandatory year of school abroad for all citizens. Now even scientific evidence suggests that it would be a good idea in the long term.

Well, when their prediction on lifespan will prove wrong the CEO will not likely be around anymore to get the blame...

🌍Open call: Junior Group Leader positions!

Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.

Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...

What an egg-cellent Sunday for oocyte papers! This week we have even TWO highlights:

pubmed.ncbi.nlm.nih.gov/41188464/ by T. Kitajima

and pubmed.ncbi.nlm.nih.gov/41184483/ by @binyammogessie.bsky.social

Read the full issue here: biomed.news/bims-cebooc/...

#cebooc
@biomednews.bsky.social

And we have another open position, this time with a focus on Genome Biology! Join a great community in Vienna to bring your research to the next level!

I have two open positions @ALMU @crg.eu:

1. Imaging Scientist (permanent position. Deadline 11th Nov.) recruitment.crg.eu/content/jobs...

2. Entry-Level Imaging Scientist (12 months fixed-term position. Deadline 18th Nov.) recruitment.crg.eu/content/jobs...

Reposts appreciated.

Happy Sunday egg-ficionados! Here comes a new issue of #cebooc!

biomed.news/bims-cebooc/...

Highlight: pubmed.ncbi.nlm.nih.gov/41173887/ on the role of mechanical forces in ovarian follicles development.

As always, thanks to @biomednews.bsky.social for preselecting!

Happy Sunday ovo-lovers! A new issue of #cebooc is here!

biomed.news/bims-cebooc/...

This week 2 stunning highlights: pubmed.ncbi.nlm.nih.gov/41129643/ and pubmed.ncbi.nlm.nih.gov/41131150/

Thanks @biomednews.bsky.social for preselecting!

Happy Sunday egg-ficionados! The latest issue of #Cebooc is here!

biomed.news/bims-cebooc/...

Highlight: pubmed.ncbi.nlm.nih.gov/41102564/

Thanks @biomednews.bsky.social for preselecting!

Tried it on a few papers that I know very well, including one that contains highly improbable data, and the comments were always spot-on. Undoubtedly a great tool to assist in reviewing and to benchmark one’s own manuscripts

Thx @biomednews.bsky.social for preselecting!

Happy Sunday!! Ready for a new spectacular issue of #cebooc?👇🏽

biomed.news/bims-cebooc/...

Highlight: PMID 41066539 on the comparison between human and mouse ovarian aging

Special mention to PMID 41066576 by @frisophagy.bsky.social on mitochondrial selection by mitophagy in the early embryo

Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations Mitochondrial synthesis of adenosine triphosphate is essential for eukaryotic life but is dependent on the cooperation of two genomes: nuclear and mitochondrial DNA (mtDNA). mtDNA mutates ~15 times as...

How can mitophagy be an effective quality control mechanism if mtDNA mutations reach high enough levels to cause disease?

This question led us into a dark path, full of concepts of evolutionary genetics, germline stem cell biology and mito-nuclear compatibility.

www.science.org/doi/10.1126/...

Sperm sequencing reveals extensive positive selection in the male germline - Nature A combination of whole-genome NanoSeq with deep whole-exome and targeted NanoSeq is used to accurately characterize mutation rates and genes under positive selection in sperm cells.

Now published! Our paper on:
(1) Accurate sequencing of sperm at scale
(2) Positive selection of spermatogenesis driver mutations across the exome
(3) Offspring disease risks from male reproductive aging
[1/n]
www.nature.com/articles/s41...

Happy Sunday egg-ficionados! Here come the latest papers on #oocyte cell biology:

biomed.news/bims-cebooc/...

Highlight: pubmed.ncbi.nlm.nih.gov/41027914/

Thanks @biomednews.bsky.social for preselecting! #cebooc

🚨JOB ALERT🚨

FRIENDS PLEASE SPREAD and RT

We are building a small expert team within the @bokelab.bsky.social at @crg.eu @prbb.org to investigate fundamental questions in oocyte cell biology, focusing on how proteostasis regulation influences dormancy and fertility.

See below 2 calls👇

A quiet ally: a ubiquitin precursor promotes stress resistance and longevity In response to cellular stress, the protein CxUb is activated to identify damaged proteins, thereby maintaining cellular health. The discovery could lead to ways to improve the treatment of cancer and...

👏Congratulations to the #CECAD Cologne's Escobar-Henriques lab and Reichert lab at the @hhu.de for their latest paper in #MolecularCell: a newly discovered #ubiquitin precursor, CxUb, plays a key role in #stress resistance and #longevity.

uni.koeln/7ET86

@unicologne.bsky.social #agingresearch

Human SCNT oocyte with visible spindle (bright spot inside) before fertilization

Human skin cells can be used to produce fertilizable eggs, according to research in Nature Communications. The study provides evidence that cell reprogramming could be a viable route in humans for addressing infertility, although further research is needed. go.nature.com/4nEbkAv 🧪

Happy Autumn! Here comes a very rich issue of #cebooc, read all the latest #papers on oocyte cell #biology here:

biomed.news/bims-cebooc/...

Highlight: pubmed.ncbi.nlm.nih.gov/40993317/

Kudos to @biomednews.bsky.social for preselecting!

It was great to attend and give a talk at the Groningen-Jena Aging Meeting (G-JAM)! Very nice conference in a great historical location! Thanks a lot to the organisers @mariaermolaeva.bsky.social and Alessandro Cellerino for the invitation! @leibnizfli.bsky.social @uni-jena.de

Happy Sunday! Ready for the latest papers on #oocyte cell biology?

Here they come! biomed.news/bims-cebooc/...

Highlight: pubmed.ncbi.nlm.nih.gov/40973727/ by @abalboula.bsky.social and @ejsm9.bsky.social

Thanks @biomednews.bsky.social for preselecting!

Happy Sunday! Here is a new issue of #cebooc, featuring the latest papers on #oocyte cell biology, enjoy!

biomed.news/bims-cebooc/...

Thanks to @biomednews.bsky.social for preselecting!

Great to see our work featured in @natsmb.nature.com!! Thanks editor @dimitristypas.bsky.social for your coverage! @bokelab.bsky.social

Happy Monday eggficionados, #cebooc is back! Ready for a new year of exciting papers on oocyte cell biology? Start now! 👇🏽

biomed.news/bims-cebooc/...

Highlight: pubmed.ncbi.nlm.nih.gov/40902605/

Thanks @biomednews.bsky.social for preselecting