Elicio ELI-002 2P: G12D G12R / ELI-002 7P: G12D G12R G12V G12A G12C G12S G13D. Preventing recurrence / delaying progression, not shrinking metastases, even though early signals are encouraging. Phase 2 mostly limited to pancreatic patients. CRC expansion cohorts planned at MD Anderson, UCLA, MSK ..

NCT05425940 - Exelixis STELLAR-303, OS 10.9 vs 9.4, Hazard Ratio 0.8 for both KRAS mutant and KRAS WT. FDA approval expected in late 2026 based on late 2025 regulatory application.
ir.exelixis.com/news-release...

NCT05425940 - Exelixis STELLAR-303, Hazard Ratio 0.8 for both KRAS mutant and KRAS WT. FDA approval expected in late 2026 based on late 2025 regulatory application.

✨#ESMO25✨

🚨 BREAKING: STELLAR-303 Phase 3 Update!

💊 Zanzalintinib + Atezolizumab (Tecentriq®) improved median OS to 10.9 months vs 9.4 months with regorafenib in metastatic colorectal cancer.

📈 The combination demonstrated a notable survival advantage in the intention-to-treat population.

I'm MSS and KRAS mutant. Exelixis just announced their phase 3 Stellar-303 trial has OS benefits for both KRAS wild and KRAS mutant patients. Hope it will get approved soon so we have more options. I will repost it.

I'm glad Vectibix is working for you! Are you MSS stable / KRAS wild type ?

I have been fighting stage 4 CRC since 2022. Thanks for your sharing.

谢谢你的例子。我认为教会在文艺复兴里对思想有限制，但也起到推动作用。不过我尊重你的意见。

多数复兴者是教会赞助的。没有教会的鼓励和资助，复兴也许不会出现。

西罗马灭国后，教会没有毁掉残存的希腊罗马文献。反而是修道院将它们保存下来研究。由此埋下复兴的火种。当大量的的文献从近东传回时，复兴终于爆发。

中世纪教会除了很多社会责任（医院，孤儿院，庇护所等），还建立了图书馆和大学（牛津，萨拉曼卡等）。

很多教会组织（本笃会、方济各会等），不依赖赋税。他们参与生产养活自己。这些修道院为农业，建筑和制造业贡献技术。类似今天的科技孵化中心。

文艺复兴期间耶稣会的宗旨是通过教育和学术传播福音，正是他们把近代科学带入中国

中世纪教会对思想的态度当然没有今天西方开放，但是可能还强过今天某些国家

持有这种观念的基督徒都是错误的，圣保罗说自己是罪人中的罪魁，连最优秀的基督徒都这么说，我就更没有什么优越感可言了。

我唯一值得骄傲的是我的上帝，在我做罪魁的时候为我牺牲，这是其他各人或者神祇不曾为我做的。

当信念建立在罪恶和感恩之上时，我才有自我纠错的动力和毅力。我想或许一个国家也是如此。

教会是文艺复兴的重要推动力量。没有教会的鼓励和财力上的支持，复兴也许都不会出现。这就像学者拿着政府的资金去做研究然后说政府打压自己一样无理。

文艺复兴是从人本的角度诠释信仰。大量题材和宗教相关，如今还体现在建筑，绘画，文学，音乐里。按我们现在看来文艺复兴就是教会的大外宣。何谈把人们从神权下解救出来？

批判教会的错误可以但也要讲道理。

😂

真的好讽刺

基督教从开始到变成国教三百年,罗马帝国一直强大。变成国教后，帝国开始分裂。西罗马一百年内灭国。一元宗教利于执政吗？
灭掉西罗马的日耳曼民族有的执政长，有的执政短。谁知道一元宗教利不利于执政。
伊斯兰进入印度1000多年，从蒙古人算起也有八百多年。一元的印度执政能力超过多元的印度吗？那么为什么800年后的今天印度仍是多元教主政呢？

政治和宗教最好远离。基督教和政治绑在一起的确犯下很多罪恶。 但是基督教比之前的多元宗教还是文明一些。不然罗马和日耳曼人也不会自动归化。 没有人逼他们这么做。

文艺复兴反对基督教？有点儿武断吧？

担心主持明天会不会被喝茶

Fate plays with people, president or not. Upon Biden’s arrival, the Taliban waxed. Upon his departure, Syria waned. Trump must feel a bit less Trump: Biden knows how to play his trump.

命运弄人，哪管你是不是总统？拜登甫上任，塔利班摧枯拉朽，让他颜面尽失。即将卸任，叙利亚叛军却排山倒海，让他光荣还乡。 特朗普有点儿眼馋: 肥肉怎可掉拜登？

哦，那就好。没有被夹头好。

司马南最近有挺叙利亚吗？

环球日报能写出这么优秀的文章，以前是我小瞧他们了。

来到Bluesky，是对马斯克的无声抗议，我将这里的人都看成持共同理念的同胞，作为一种courtesy，所有fo我的人我都回fo；骂川普八年也骂累了，分享了一些个人生活感悟。结果引开大量骗子，不得不关闭私聊。还是得彻底清理一下关注，也请那些放张美女头像的别再fo我，我一把年纪了，早已油盐不进、片叶不沾。Bluesky也得下点功夫清理门户，别像X那样乌烟瘴气，最终会影响平台声誉。

👏

“If I could give you information of my life, it would be to show how a woman of very ordinary ability has been led by God in strange and unaccustomed paths to do In His service what He ha... - Nightingale In this quote, Florence Nightingale reflects on the humility and divine guidance that shaped her life and work. She acknowledges that, by worldly standards, she may have been a woman of ordinary ability, yet she believes that it was through God’s guidance that she was led to accomplish extraordinary things in the field of nursing and public health. Nightingale’s words emphasize that her achievements were not the result of her own power or exceptional talents, but rather a manifestation of God’s will working through her. This perspective reveals her deep sense of faith and humility, where she attributed her success not to her own efforts, but to a higher purpose that directed her path.

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#Nightingale
“If I could give you information of my life, it would be to show how a woman of very ordinary ability has been led by God in strange and unaccustomed paths to do In His service what He ha...

#Quotes #aphorisms #Lifelong #Learning #Life #Lessons

梅洛尼和马斯克今天于巴黎再次相见。

Meloni and Musk saw each other again in Paris.

大概六百万叙利亚人因为内战逃亡他国。现政府倒台之后，有多少难民会重新回到这个国家，重建家园？

About six million Syrians have fled the civil war. How many of them will return to rebuild their homes after the current government falls?

大马士革传来的视频，似乎显示军人开始逃离。

韩国前防长因为参与戒严被羁留。

Former South Korean defense minister detained for executing the martial law order.

México lindo y querido tiene la Peña de Bernal en Querétaro, el tercer más grande monolito en el mundo.