Amy Thompson

VMXm has postcards! Available from the beamline or a member of the VMXm team if you see us at conferences. Do reach out to us for your microcrystal X-ray diffraction experiments.

The first @diamondlightsource.bsky.social MX Newsletter is here! Including the latest news from the MX beamlines, helpful info about shutdowns, runs and training opportunities as well as useful tips and tricks for making the most of the MX beamlines at Diamond. www.diamond.ac.uk/Instruments/...

Time-resolved serial synchrotron and serial femtosecond crystallography of heme proteins using photocaged nitric oxide We demonstrate the application of a nitric oxide releasing photocage system for time-resolved serial crystallography studies of two heme containing proteins using a fixed target sample delivery system. Optimal parameters for successful photocage activation and nitric oxide release are explored.

Peter Smyth et al.: Time-resolved serial synchrotron and serial femtosecond crystallography of heme proteins using photocaged nitric oxide #TimeResolvedXRayCrystallography #SerialCrystallography @Uni_of_Essex...#IUCr https://journals.iucr.org/paper?S2052252525006645

Time-resolved serial synchrotron and serial femtosecond crystallography of heme proteins using photocaged nitric oxide We demonstrate the application of a nitric oxide releasing photocage system for time-resolved serial crystallography studies of two heme containing proteins using a fixed target sample delivery system...

New paper describing use of photocaged nitric oxide for time resolved crystallography within fixed targets at XFEL and synchrotron - PhD work of Pete Smyth & Lewis Williams - great collaboration with @jarworrall.bsky.social, beamline I24 and SACLA. Funded by BBSRC
journals.iucr.org/m/issues/202...

Registration is open for the September on-site MX user training. If you are an MX user of @diamondlightsource.bsky.social then please to apply to attend - spaces are limited. You'll have the opportunity to visit and learn about all the MX beamlines, data analysis as well as all things logistics.

Having a great time in York teaching crystallographic data reduction - great to see the students so engaged and asking really good questions! #ccp4

Wrapped up another conference for the year at the #ACA2025 - thanks to the organisers for putting on a great conference! I greatly enjoyed bringing my work on clustering 🐮🐷🤷‍♀️ to a new audience - the conference dinner had some pretty neat views too!

Enhancements of the intensity-clustering algorithms available within DIALS and utilized by xia2.multiplex are described and demonstrated #MultiCrystalDataSets #DataProcessing #Clustering doi.org/10.1107/S205...

Enhanced intensity-based clustering of isomorphous multi-crystal data sets in the presence of subtle variations Bovine, porcine and human insulin data sets are isomorphous in terms of unit cell and symmetry. Through enhancements to the multi-crystal clustering methods in DIALS, species-pure data sets are automa...

Paper describing clustering methods to separate subtle structural differences in populations of protein crystals - with application to polymorphs, ligand binding.. - led by Amy Thompson @amyjayyyne.bsky.social with VMXi,I24 and Data Analysis at @ddiamond.bsky.social journals.iucr.org/d/issues/202...

Enhanced intensity-based clustering of isomorphous multi-crystal data sets in the presence of subtle variations Bovine, porcine and human insulin data sets are isomorphous in terms of unit cell and symmetry. Through enhancements to the multi-crystal clustering methods in DIALS, species-pure data sets are automa...

Thrilled to have this work published! Thanks to some awesome teamwork, we've demonstrated improvements in multi-crystal data clustering by automatically separating 🐮🐷🧑‍🔬 #multicrystal #clustering #crystallography doi.org/10.1107/S205...

This was my first step into the world of XFELs - a great team to collaborate with!

Having a great time at the BCA - thanks to the organisers for putting on a great conference and inviting me to present!

Our own @amyjayyyne.bsky.social from @diamondlightsource.bsky.social presenting VMXi at @crystallography.org.uk . Great talk!

legobox set of I24 which accordi g to google is the worlds best tuneable microfocus mx beamline in the world

Participants in the annual serial crystallography workshop for graduates student some funded by our @wellcometrust.bsky.social PhD program have got homework to do in the evening time …. @diamondlightsource.bsky.social @instruct-eric.bsky.social

Crystals can’t bend – or can they? New research sheds light on elusive ‘flexible crystals’ Crystals are supposed to be hard and brittle. But when we make them bendy, they help reveal the secrets of how elastic materials work.

theconversation.com/crystals-can...

Super exciting to have this finally out! It was great to have different fields coming together for this collaboration