Jonathan Bohlen

Excited to participate in this symposium!

Very nice review on genetic insights to B cell development: rupress.org/jhi/article/... by @alneehus.bsky.social and @bloodgenes.bsky.social

Innate immune system: How modified RNA tricks the immune system Researchers at LMU have elucidated why certain RNA modifications do not trigger an immune response—a key mechanism for RNA therapeutics.

🥳Amazing publication from the Hornung lab, in collab. with the Carell lab, on the innate immune system: how modified RNA tricks the immune system. Big shout-out to the two first authors, Marleen Bérouti and Mirko Wagner! www.cell.com/cell/fulltex...
@v-hornung.bsky.social @m-berouti.bsky.social

Whaaaat!=!=!=

Graphical abstract of the linked paper. Sea slugs retain and store foreign chloroplasts in kleptosome organelles (top). Kleptosomes use luminal ATP-sensing ion channels to support photosynthesis (bottom left). Kleptosomes digest chloroplasts during prolonged starvation (bottom center). Slugs and corals use convergent mechanisms of endosymbiosis (bottom right).

@nbellono.bsky.social and colleagues observed that Elysia sea slugs steal chloroplasts from algae and store them in specialized organelles called kleptosomes. During times of starvation, this allows them to photosynthesize in support of their energy needs! 🧪

www.cell.com/cell/abstrac...

Evaluating IL1RA‐Autoantibodies Across SARS‐CoV‐2‐Related Diseases Click on the article title to read more.

No evidence for neutralizing IL1RN autoantibodies in our cohorts of MIS-C, SARS-CoV2 pneumonia or vaccine-induced myocarditis. onlinelibrary.wiley.com/doi/10.1111/... Great work by Anish Behere in Nils Landegren lab, Uppsala university

We are looking for motivated Master Students who are interested to start an internship or thesis in the fall. The project will focus on molecular biology of mRNA translation and is a great opportunity to master some staple methods. Please get in touch @genecenter-lmu.bsky.social tinyurl.com/3f3kwmja

Outstanding poster!!

Congrats to the authors! Amazing method!

Congrats! This is super cool.

Congrats!! Well deserved!

Yes, totally agree! What's your favorite? I'd probably say Tbet :)

Comprehensive and convincing report of a new IEI, with just a single patient! Congrats Stuart and the team. Stellar!

Wow, very cool and unexpected findings!

Thank you, that's very clear! Congrats again :)

Fascinating!

And of course congrats for the terrific work!!

Hi Huiqing,
as an occasional sequencer of tRNAs I would be really grateful for a short thread on this paper! I'd be especially curious about where you see the advantages / disadvantages of this compared to other state-of-the-art methods like mim-tRNA-seq, which also identifies many modifications THX

A PhD position is open in my group here in Heidelberg. We'll use cool primary cell models of osteosarcoma and genetic screens to understand and overcome mechanisms of clinically acquired drug resistance. It'll be a blast!

karriere.klinikum.uni-heidelberg.de/index.php?ac...

Excited to welcome Evan and exchange ideas!

Congrats Ahmad! amazing paper and discovery!

1/ One of the most intriguing enigmas of the #COVID19 pandemic was the sudden and unprecedented outbreak of chilblains that accompanied the early waves of #SARSCoV2 infections. Our new study in @jem.org uncovers the underlying immunological mechanism

rupress.org/jem/article/...

I agree, NAR is just a great journal and I've had several excellent experiences with their editorial process.

Role of clonal inflammatory microglia in histiocytosis-associated neurodegeneration Vicario et al. detected microglial mosaicism in histiocytosis patients, predominantly in the rhombencephalon gray nuclei and associated with astrocytosis, neuronal loss, and neurological symptoms in p...

Role of clonal inflammatory microglia in histiocytosis-associated neurodegeneration: Neuron www.cell.com/neuron/fullt...

Congrats!!

Description Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...

*******JOB ALERT*********
Join our team as a Postdoc or Research Assistant investigating the genetic basis of life-threatening infections in children @imperialcollege .
Apply now

🔗 rb.gy/1c6b3n #ScienceJobs #Postdoc #Immunology #IEI #Humangenetics @imperialinfect.bsky.social

Posttranscriptional activity of the eukaryotic translation initiation factor eIF4E contributes to HoxA9-driven leukemogenesis HoxA9, a homeodomain-containing transcription factor, is mis-expressed in over half of acute myeloid leukemia (AML) cases, and is associated with poor prognosis. Previous studies indicated that HoxA9 ...

Very cool and surprising! A transcription factor is also a translation factor: www.biorxiv.org/content/10.1...

Long-term imaging of individual ribosomes reveals ribosome cooperativity in mRNA translation Ribosomes cooperate through transient collisions to ensure efficient translation.

Amazing stuff from @marvintanenbaum.bsky.social!

Long-term imaging of individual ribosomes reveals ribosome cooperativity in mRNA translation: Cell www.cell.com/cell/fulltex...
#RNAsky #RNABiology

Sounds great! Congrats & looking forward to read it!

I wonder what this costs.