Ece Atayeter

A protein complex in the extreme distal tip of vertebrate motile cilia controls their organization, length, and function - Nature Communications Here they combine in vivo imaging with proteomics to characterize a protein complex comprised of Ccdc78 and Ccdc33 that acts at the extreme distal tip of 9 + 2 motile cilia to control tip architecture...

Cilia alert! Stoked to have the new paper from Juyeon Hong about a new domain at the extreme distal tip of motile cilia! (The EDT, y'all!) It's out now @natcomms.nature.com.
Check it out!
#cilia

www.nature.com/articles/s41...

In December's #EditorsChoice, Nayeli Reyes-Nava, @edwardmarcotte.bsky.social, @jbwallingford.bsky.social & co use #Xenopus model to study #Cilia motility disturbances in primary ciliary dyskinesia #PCD

⚡ doi.org/10.1242/dmm....
📰 doi.org/10.1242/dmm....

‼️‼️Preprint alert! ‼️‼️🔬🔬
New cilia quantification tool: Cilia.io

The human ciliopathy protein RSG1 links the CPLANE complex to transition zone architecture - Nature Communications The CPLANE complex is essential for ciliogenesis, and mutations to all but one subunit have been associated with ciliopathies. Here they identify three familial mutations in the final subunit, RSG1, t...

Cilia Alert! So excited to finally have this paper on the CPLANE complex out in @natcomms.nature.com! We show that RSG1 is a human ciliopathy protein and links CPLANE to the transition zone. 1/n

www.nature.com/articles/s41...

Cell expansion for notochord mechanics and endochondral bone lengthening in zebrafish depends on the 5′-inositol phosphatase Inppl1a Voigt et al. show that the 5′-inositol phosphatase gene inppl1a drives notochord expansion independent of vacuole fusion. Defects in notochord expansion are exacerbated by locomotion, causing more sev...

Finally out! Brittney Voigt et al show the shared role of Inppl1a expansion of notochord vacuolated cells and also for hypertrophy of chondorcytes and bone lengthening. @currentbiology.bsky.social www.cell.com/current-biol...

Revisited with #ezReverse. Credit to @joachimgoedhart.bsky.social. #ZebrafishZunday 🧪

Web app: amsterdamstudygroup.shinyapps.io/ezreverse/

Molecular organization of the distal tip of vertebrate motile cilia The beating of cilia on multi-ciliated cells (MCCs) is essential for normal development and homeostasis in animals. Unlike basal bodies or axonemes, the distal tips of MCC cilia remain poorly defined....

Preprint Alert! Juyeon Hong in the lab has dissected the molecular organization of distal tips of vertebrate motile cilia. She even found a new compartment in the extreme distal tip marked by Ccdc78 and Ccdc33. Give it a read!
@biorxiv-cellbio.bsky.social

www.biorxiv.org/content/10.1...