Maximilian Frey

The baby whose life was saved by the first personalized CRISPR therapy KJ Muldoon is part of Nature’s 10, a list of people who shaped science in 2025.

KJ Muldoon, at less than a year old, was the first known person to receive a personalised CRISPR-based genome-editing therapy

He is part of Nature’s 10, a list of people who shaped science in 2025

go.nature.com/48GqTl3

Will blockbuster obesity drugs revolutionize addiction treatment? Scientists are testing whether GLP-1 drugs can help to cut cravings for cigarettes, alcohol and opioids — as well as food.

GLP-1 drugs can help people lose weight by quelling hunger queues. Nature reports on the work by scientists testing if these drugs can help to cut cravings for cigarettes, alcohol and opioids. 🧪

The Microflora Danica atlas of Danish environmental microbiomes - Nature Microflora Danica—an atlas of Danish environmental microbiomes—reveals that although human-disturbed habitats have high alpha diversity, species reoccur, revealing hidden homogeneity.

Denmark just mapped its entire environmental microbiome. More than 10,000 samples revealing hidden, dominant nitrifiers that shape fertilizer use, water quality, and climate impact. A national microbiome atlas could transform sustainable agriculture across Europe.
#AMR
www.nature.com/articles/s41...

Happy to see our review published in issue 11 of Natural Products Reports. 😊

Biosynthesis of biologically active terpenoids in the mint family (Lamiaceae) Covering: 2000 to 2025 The Lamiaceae family, the sixth largest among angiosperms, is renowned for its rich diversity of terpenoids, many of which exhibit remarkable bioactivities, including…

🔓Don't miss in our latest issue this #OpenAccess review by @maximilianfrey.bsky.social & co. @ipbhalle.bsky.social, @unihalle.bsky.social & @mpi-ce.bsky.social looking at the biosynthesis of biologically active terpenoids in the mint family #naturalproducts #secmet

The MassBank contributions of the mFam Consortium
A Global Push to Boost Coverage and Diversity of MassBank
chemrxiv.org/engage/api-g...
Happy to have contributed.

Extraction of Essential Oils and Terpene Volatiles from Plants and Identification by GC-MS-Based Techniques The extraction of plant essential oils (EOs) and analysis by gas chromatography coupled to mass spectrometry (GC-MS) are standard methods when studying aromatic plants and the chemical composition of ...

The book "Natural Product Isolation and Identification" is now online. Happy to contribute to a protocol: "Extraction of Essential Oils and Terpene Volatiles from Plants and Identification by GC-MS-Based Techniques" (Krause & Frey, 2025)

link.springer.com/protocol/10....

An independent biosynthetic route to frame a xanthanolide‐type sesquiterpene lactone in Asteraceae Xanthanolide-type sesquiterpene lactones (STLs) are promising candidates for anti-cancer drug development. Since the middle of the last century, when the structure of the first xanthanolide-type STL ...

- Elucidation of a biosynthetic route to xanthanolide sesquiterpene lactones: onlinelibrary.wiley.com/doi/abs/10.1...

Sesquiterpene Lactones – Insights into Biosynthesis, Regulation and Signalling Roles Sesquiterpene lactones (STLs) are bitter tasting plant specialized metabolites derived from farnesyl pyrophosphate (FPP) that contain a characteristic lactone ring. STLs can be found in many plant ...

Our review paper on sesquiterpene lactones was published one year ago in February 2024. Since then there have been some fascinating developments in the field:

Full article: Sesquiterpene Lactones – Insights into Biosynthesis, Regulation and Signalling Roles www.tandfonline.com/doi/full/10....

www.mdpi.com/1420-3049/30...

We just published the paper "Cytochrome P450-Induced Backbone Rearrangements in Terpene Biosynthesis of Plants" in Molecules. Thanks to everyone involved. :)

Biosynthesis of biologically active terpenoids in the mint family (Lamiaceae) Covering: 2000 to 2025The Lamiaceae family, the sixth largest among angiosperms, is renowned for its rich diversity of terpenoids, many of which exhibit remarkable bioactivities, including anti-inflam...

pubs.rsc.org/en/content/a...

We just published the paper Biosynthesis of biologically active terpenoids in the mint family (Lamiaceae) in Natural Products Reports.

Thanks to everyone involved! :)

www.mdpi.com/1420-3049/30...

We just published the paper "Cytochrome P450-Induced Backbone Rearrangements in Terpene Biosynthesis of Plants" in Molecules. Thanks to everyone involved. :)

Biosynthesis of biologically active terpenoids in the mint family (Lamiaceae) Covering: 2000 to 2025The Lamiaceae family, the sixth largest among angiosperms, is renowned for its rich diversity of terpenoids, many of which exhibit remarkable bioactivities, including anti-inflam...

pubs.rsc.org/en/content/a...

We just published the paper Biosynthesis of biologically active terpenoids in the mint family (Lamiaceae) in Natural Products Reports.

Thanks to everyone involved! :)

Meet Aeneas: the AI that can fill in the gaps of damaged Latin texts The best results come when a human and the model work together.

This AI model can predict where ancient Latin texts come from, estimate how old they are and restore missing parts

go.nature.com/4lLQwGr

Und auch unsere Expertin Mariana Schuster @marischuster.bsky.social könnt ihr am 3.6. ausfragen, wie das Immunsystem bei Pflanzen funktioniert und warum das überhaupt wichtig ist. 🥬💚(Auf 🇩🇪 oder 🇬🇧)

👉Hier #BookAScientist buchen: www.leibniz-gemeinschaft.de/ueber-uns/ne...
#wisskomm #PlantSci #scicomm

🎉We are delighted to welcome Professor Neha Garg @ngarg10.bsky.social from @gtresearchnews.bsky.social to the @natprodreports.rsc.org Editorial Board! #chemsky #natprod

Learn more about Neha here🔽
blogs.rsc.org/np/2025/04/0...

Lässt sich der Nährwert von Gerste steigern? Wie können Pflanzen mehr Zellulose bilden? Fragen wie diese stehen im Zentrum des neuen Forschungsverbunds „Value Plant“ der Uni Halle, der mit rund 7,1 Mio. Euro gefördert wird. Verbundsprecher ist Prof. Dr. Ingo Heilmann von der MLU. mlu.de/6evf0

Celebrating the 10-year anniversary of my Python for Life Scientists course at Uni Bonn! 🎉
Proud to have shared coding skills with so many researchers over the years.
📂 Slides are available on GitHub: github.com/bpucker/PyBo
#Python #LifeScience #OpenScience #Teaching
@puckerlab.bsky.social

European Union takes giant leap forward toward embracing technologically-enhanced agriculture, advances de-regulation of gene edited crops On Friday 14 March 2025, Member States' representatives (Coreper) endorsed the Council's negotiating mandate on the regulation on plants obtained by new genomic techniques (NGTs) and their food and fe...

European Union takes giant leap forward toward embracing technologically-enhanced agriculture, advances de-regulation of gene edited crops geneticliteracyproject.org/2025/03/17/e...

Wrapping up our Applied Plant Transcriptomics course! From RNA-seq to de novo transcriptome assembly.
#Bioinformatics #PlantSciences
📑 Slides available here: github.com/bpucker/Appl...

🧪 In these days, we all need some positive news 😀: Check out our latest work that has tremendous impact on patients’ lives. That’s why we all need science!🧪 A big thank you to all coauthors! 👏👏
@unihalle.bsky.social @unileipzig.bsky.social #Academicsky #MedSky #ADCY5
@standupforscience.bsky.social

What a title!
"This is the way the world ends; not with a bang but a whimper: Estimating the number and ongoing rate of extinctions of Australian non-marine invertebrates"
Biodiversity declines really concerning.
👉 www.cambridge.org/core/journal...

Ergosterol‐induced immune response in barley involves phosphorylation of phosphatidylinositol phosphate metabolic enzymes and activation of diterpene biosynthesis Lipids play crucial roles in plant–microbe interactions, functioning as structural components, signaling molecules, and microbe-associated molecular patterns (MAMPs). However, the mechanisms underly...

Latest story from Pia Saake: Plant Lipids Mediate Immune Responses to Fungal Lipids in Barley!

nph.onlinelibrary.wiley.com/doi/full/10....

#BlackHistoryMonth Plant Scientist Spotlight - Meet Sibongile Mafu!🌱

👉 See the full list of incredible plant scientists featured at buff.ly/41fCJQn

#plantscience

Let’s kick off this kick-off!
Today and tomorrow we are meeting at the @ipbhalle.bsky.social to officially start the #snp2prot journey as a team 💪

- The rapidly growing number of genomes of STL producing Asteraceae plants: www.ncbi.nlm.nih.gov/datasets/gen...

...next updates in one year ;)

An independent biosynthetic route to frame a xanthanolide‐type sesquiterpene lactone in Asteraceae Xanthanolide-type sesquiterpene lactones (STLs) are promising candidates for anti-cancer drug development. Since the middle of the last century, when the structure of the first xanthanolide-type STL ...

- Elucidation of a biosynthetic route to xanthanolide sesquiterpene lactones: onlinelibrary.wiley.com/doi/abs/10.1...

Volatile communication in plants relies on a KAI2-mediated signaling pathway Informational exchange in plants occurs stereospecifically via volatile terpenoids and the KAI2-like signaling pathway.

- Identification of a sesquiterpene Kai2 receptor ligand: www.science.org/doi/10.1126/...

Sesquiterpene Lactones – Insights into Biosynthesis, Regulation and Signalling Roles Sesquiterpene lactones (STLs) are bitter tasting plant specialized metabolites derived from farnesyl pyrophosphate (FPP) that contain a characteristic lactone ring. STLs can be found in many plant ...

Our review paper on sesquiterpene lactones was published one year ago in February 2024. Since then there have been some fascinating developments in the field:

Full article: Sesquiterpene Lactones – Insights into Biosynthesis, Regulation and Signalling Roles www.tandfonline.com/doi/full/10....